Daily Papers

We present Contrastive Feature Masking Vision Transformer (CFM-ViT) - an image-text pretraining methodology that achieves simultaneous learning of image- and region-level representation for open-vocabulary object detection (OVD). Our approach combines the masked autoencoder (MAE) objective into the contrastive learning objective to improve the representation for localization tasks. Unlike standard MAE, we perform reconstruction in the joint image-text embedding space, rather than the pixel space as is customary with the classical MAE method, which causes the model to better learn region-level semantics. Moreover, we introduce Positional Embedding Dropout (PED) to address scale variation between image-text pretraining and detection finetuning by randomly dropping out the positional embeddings during pretraining. PED improves detection performance and enables the use of a frozen ViT backbone as a region classifier, preventing the forgetting of open-vocabulary knowledge during detection finetuning. On LVIS open-vocabulary detection benchmark, CFM-ViT achieves a state-of-the-art 33.9 APr, surpassing the best approach by 7.6 points and achieves better zero-shot detection transfer. Finally, CFM-ViT acquires strong image-level representation, outperforming the state of the art on 8 out of 12 metrics on zero-shot image-text retrieval benchmarks.

The Position Embedding (PE) is critical for Vision Transformers (VTs) due to the permutation-invariance of self-attention operation. By analyzing the input and output of each encoder layer in VTs using reparameterization and visualization, we find that the default PE joining method (simply adding the PE and patch embedding together) operates the same affine transformation to token embedding and PE, which limits the expressiveness of PE and hence constrains the performance of VTs. To overcome this limitation, we propose a simple, effective, and robust method. Specifically, we provide two independent layer normalizations for token embeddings and PE for each layer, and add them together as the input of each layer's Muti-Head Self-Attention module. Since the method allows the model to adaptively adjust the information of PE for different layers, we name it as Layer-adaptive Position Embedding, abbreviated as LaPE. Extensive experiments demonstrate that LaPE can improve various VTs with different types of PE and make VTs robust to PE types. For example, LaPE improves 0.94% accuracy for ViT-Lite on Cifar10, 0.98% for CCT on Cifar100, and 1.72% for DeiT on ImageNet-1K, which is remarkable considering the negligible extra parameters, memory and computational cost brought by LaPE. The code is publicly available at https://github.com/Ingrid725/LaPE.

Regional dropout strategies have been proposed to enhance the performance of convolutional neural network classifiers. They have proved to be effective for guiding the model to attend on less discriminative parts of objects (e.g. leg as opposed to head of a person), thereby letting the network generalize better and have better object localization capabilities. On the other hand, current methods for regional dropout remove informative pixels on training images by overlaying a patch of either black pixels or random noise. Such removal is not desirable because it leads to information loss and inefficiency during training. We therefore propose the CutMix augmentation strategy: patches are cut and pasted among training images where the ground truth labels are also mixed proportionally to the area of the patches. By making efficient use of training pixels and retaining the regularization effect of regional dropout, CutMix consistently outperforms the state-of-the-art augmentation strategies on CIFAR and ImageNet classification tasks, as well as on the ImageNet weakly-supervised localization task. Moreover, unlike previous augmentation methods, our CutMix-trained ImageNet classifier, when used as a pretrained model, results in consistent performance gains in Pascal detection and MS-COCO image captioning benchmarks. We also show that CutMix improves the model robustness against input corruptions and its out-of-distribution detection performances. Source code and pretrained models are available at https://github.com/clovaai/CutMix-PyTorch .

Joint-Embedding Self Supervised Learning (JE-SSL) has seen a rapid development, with the emergence of many method variations but only few principled guidelines that would help practitioners to successfully deploy them. The main reason for that pitfall comes from JE-SSL's core principle of not employing any input reconstruction therefore lacking visual cues of unsuccessful training. Adding non informative loss values to that, it becomes difficult to deploy SSL on a new dataset for which no labels can help to judge the quality of the learned representation. In this study, we develop a simple unsupervised criterion that is indicative of the quality of the learned JE-SSL representations: their effective rank. Albeit simple and computationally friendly, this method -- coined RankMe -- allows one to assess the performance of JE-SSL representations, even on different downstream datasets, without requiring any labels. A further benefit of RankMe is that it does not have any training or hyper-parameters to tune. Through thorough empirical experiments involving hundreds of training episodes, we demonstrate how RankMe can be used for hyperparameter selection with nearly no reduction in final performance compared to the current selection method that involve a dataset's labels. We hope that RankMe will facilitate the deployment of JE-SSL towards domains that do not have the opportunity to rely on labels for representations' quality assessment.

Recent studies show that paddings in convolutional neural networks encode absolute position information which can negatively affect the model performance for certain tasks. However, existing metrics for quantifying the strength of positional information remain unreliable and frequently lead to erroneous results. To address this issue, we propose novel metrics for measuring (and visualizing) the encoded positional information. We formally define the encoded information as PPP (Position-information Pattern from Padding) and conduct a series of experiments to study its properties as well as its formation. The proposed metrics measure the presence of positional information more reliably than the existing metrics based on PosENet and a test in F-Conv. We also demonstrate that for any extant (and proposed) padding schemes, PPP is primarily a learning artifact and is less dependent on the characteristics of the underlying padding schemes.

This paper presents SimCSE, a simple contrastive learning framework that greatly advances state-of-the-art sentence embeddings. We first describe an unsupervised approach, which takes an input sentence and predicts itself in a contrastive objective, with only standard dropout used as noise. This simple method works surprisingly well, performing on par with previous supervised counterparts. We find that dropout acts as minimal data augmentation, and removing it leads to a representation collapse. Then, we propose a supervised approach, which incorporates annotated pairs from natural language inference datasets into our contrastive learning framework by using "entailment" pairs as positives and "contradiction" pairs as hard negatives. We evaluate SimCSE on standard semantic textual similarity (STS) tasks, and our unsupervised and supervised models using BERT base achieve an average of 76.3% and 81.6% Spearman's correlation respectively, a 4.2% and 2.2% improvement compared to the previous best results. We also show -- both theoretically and empirically -- that the contrastive learning objective regularizes pre-trained embeddings' anisotropic space to be more uniform, and it better aligns positive pairs when supervised signals are available.

As it is empirically observed that Vision Transformers (ViTs) are quite insensitive to the order of input tokens, the need for an appropriate self-supervised pretext task that enhances the location awareness of ViTs is becoming evident. To address this, we present DropPos, a novel pretext task designed to reconstruct Dropped Positions. The formulation of DropPos is simple: we first drop a large random subset of positional embeddings and then the model classifies the actual position for each non-overlapping patch among all possible positions solely based on their visual appearance. To avoid trivial solutions, we increase the difficulty of this task by keeping only a subset of patches visible. Additionally, considering there may be different patches with similar visual appearances, we propose position smoothing and attentive reconstruction strategies to relax this classification problem, since it is not necessary to reconstruct their exact positions in these cases. Empirical evaluations of DropPos show strong capabilities. DropPos outperforms supervised pre-training and achieves competitive results compared with state-of-the-art self-supervised alternatives on a wide range of downstream benchmarks. This suggests that explicitly encouraging spatial reasoning abilities, as DropPos does, indeed contributes to the improved location awareness of ViTs. The code is publicly available at https://github.com/Haochen-Wang409/DropPos.

Supervised learning can be viewed as distilling relevant information from input data into feature representations. This process becomes difficult when supervision is noisy as the distilled information might not be relevant. In fact, recent research shows that networks can easily overfit all labels including those that are corrupted, and hence can hardly generalize to clean datasets. In this paper, we focus on the problem of learning with noisy labels and introduce compression inductive bias to network architectures to alleviate this over-fitting problem. More precisely, we revisit one classical regularization named Dropout and its variant Nested Dropout. Dropout can serve as a compression constraint for its feature dropping mechanism, while Nested Dropout further learns ordered feature representations w.r.t. feature importance. Moreover, the trained models with compression regularization are further combined with Co-teaching for performance boost. Theoretically, we conduct bias-variance decomposition of the objective function under compression regularization. We analyze it for both single model and Co-teaching. This decomposition provides three insights: (i) it shows that over-fitting is indeed an issue for learning with noisy labels; (ii) through an information bottleneck formulation, it explains why the proposed feature compression helps in combating label noise; (iii) it gives explanations on the performance boost brought by incorporating compression regularization into Co-teaching. Experiments show that our simple approach can have comparable or even better performance than the state-of-the-art methods on benchmarks with real-world label noise including Clothing1M and ANIMAL-10N. Our implementation is available at https://yingyichen-cyy.github.io/CompressFeatNoisyLabels/.

PixelCNNs are a recently proposed class of powerful generative models with tractable likelihood. Here we discuss our implementation of PixelCNNs which we make available at https://github.com/openai/pixel-cnn. Our implementation contains a number of modifications to the original model that both simplify its structure and improve its performance. 1) We use a discretized logistic mixture likelihood on the pixels, rather than a 256-way softmax, which we find to speed up training. 2) We condition on whole pixels, rather than R/G/B sub-pixels, simplifying the model structure. 3) We use downsampling to efficiently capture structure at multiple resolutions. 4) We introduce additional short-cut connections to further speed up optimization. 5) We regularize the model using dropout. Finally, we present state-of-the-art log likelihood results on CIFAR-10 to demonstrate the usefulness of these modifications.

Relative positional embeddings (RPE) have received considerable attention since RPEs effectively model the relative distance among tokens and enable length extrapolation. We propose KERPLE, a framework that generalizes relative position embedding for extrapolation by kernelizing positional differences. We achieve this goal using conditionally positive definite (CPD) kernels, a class of functions known for generalizing distance metrics. To maintain the inner product interpretation of self-attention, we show that a CPD kernel can be transformed into a PD kernel by adding a constant offset. This offset is implicitly absorbed in the Softmax normalization during self-attention. The diversity of CPD kernels allows us to derive various RPEs that enable length extrapolation in a principled way. Experiments demonstrate that the logarithmic variant achieves excellent extrapolation performance on three large language modeling datasets. Our implementation and pretrained checkpoints are released at https://github.com/chijames/KERPLE.git.

Convolutional neural networks (CNN) are capable of learning robust representation with different regularization methods and activations as convolutional layers are spatially correlated. Based on this property, a large variety of regional dropout strategies have been proposed, such as Cutout, DropBlock, CutMix, etc. These methods aim to promote the network to generalize better by partially occluding the discriminative parts of objects. However, all of them perform this operation randomly, without capturing the most important region(s) within an object. In this paper, we propose Attentive CutMix, a naturally enhanced augmentation strategy based on CutMix. In each training iteration, we choose the most descriptive regions based on the intermediate attention maps from a feature extractor, which enables searching for the most discriminative parts in an image. Our proposed method is simple yet effective, easy to implement and can boost the baseline significantly. Extensive experiments on CIFAR-10/100, ImageNet datasets with various CNN architectures (in a unified setting) demonstrate the effectiveness of our proposed method, which consistently outperforms the baseline CutMix and other methods by a significant margin.

Transformer architectures rely on explicit position encodings in order to preserve a notion of word order. In this paper, we argue that existing work does not fully utilize position information. For example, the initial proposal of a sinusoid embedding is fixed and not learnable. In this paper, we first review absolute position embeddings and existing methods for relative position embeddings. We then propose new techniques that encourage increased interaction between query, key and relative position embeddings in the self-attention mechanism. Our most promising approach is a generalization of the absolute position embedding, improving results on SQuAD1.1 compared to previous position embeddings approaches. In addition, we address the inductive property of whether a position embedding can be robust enough to handle long sequences. We demonstrate empirically that our relative position embedding method is reasonably generalized and robust from the inductive perspective. Finally, we show that our proposed method can be adopted as a near drop-in replacement for improving the accuracy of large models with a small computational budget.

Introduced by Hinton et al. in 2012, dropout has stood the test of time as a regularizer for preventing overfitting in neural networks. In this study, we demonstrate that dropout can also mitigate underfitting when used at the start of training. During the early phase, we find dropout reduces the directional variance of gradients across mini-batches and helps align the mini-batch gradients with the entire dataset's gradient. This helps counteract the stochasticity of SGD and limit the influence of individual batches on model training. Our findings lead us to a solution for improving performance in underfitting models - early dropout: dropout is applied only during the initial phases of training, and turned off afterwards. Models equipped with early dropout achieve lower final training loss compared to their counterparts without dropout. Additionally, we explore a symmetric technique for regularizing overfitting models - late dropout, where dropout is not used in the early iterations and is only activated later in training. Experiments on ImageNet and various vision tasks demonstrate that our methods consistently improve generalization accuracy. Our results encourage more research on understanding regularization in deep learning and our methods can be useful tools for future neural network training, especially in the era of large data. Code is available at https://github.com/facebookresearch/dropout.

Deep neural networks often work well when they are over-parameterized and trained with a massive amount of noise and regularization, such as weight decay and dropout. Although dropout is widely used as a regularization technique for fully connected layers, it is often less effective for convolutional layers. This lack of success of dropout for convolutional layers is perhaps due to the fact that activation units in convolutional layers are spatially correlated so information can still flow through convolutional networks despite dropout. Thus a structured form of dropout is needed to regularize convolutional networks. In this paper, we introduce DropBlock, a form of structured dropout, where units in a contiguous region of a feature map are dropped together. We found that applying DropbBlock in skip connections in addition to the convolution layers increases the accuracy. Also, gradually increasing number of dropped units during training leads to better accuracy and more robust to hyperparameter choices. Extensive experiments show that DropBlock works better than dropout in regularizing convolutional networks. On ImageNet classification, ResNet-50 architecture with DropBlock achieves 78.13% accuracy, which is more than 1.6% improvement on the baseline. On COCO detection, DropBlock improves Average Precision of RetinaNet from 36.8% to 38.4%.

Window attention, position embeddings, and high resolution finetuning are core concepts in the modern transformer era of computer vision. However, we find that naively combining these near ubiquitous components can have a detrimental effect on performance. The issue is simple: interpolating position embeddings while using window attention is wrong. We study two state-of-the-art methods that have these three components, namely Hiera and ViTDet, and find that both do indeed suffer from this bug. To fix it, we introduce a simple absolute window position embedding strategy, which solves the bug outright in Hiera and allows us to increase both speed and performance of the model in ViTDet. We finally combine the two to obtain HieraDet, which achieves 61.7 box mAP on COCO, making it state-of-the-art for models that only use ImageNet-1k pretraining. This all stems from what is essentially a 3 line bug fix, which we name "absolute win".

Dropout is a simple but efficient regularization technique for achieving better generalization of deep neural networks (DNNs); hence it is widely used in tasks based on DNNs. During training, dropout randomly discards a portion of the neurons to avoid overfitting. This paper presents an enhanced dropout technique, which we call multi-sample dropout, for both accelerating training and improving generalization over the original dropout. The original dropout creates a randomly selected subset (called a dropout sample) from the input in each training iteration while the multi-sample dropout creates multiple dropout samples. The loss is calculated for each sample, and then the sample losses are averaged to obtain the final loss. This technique can be easily implemented by duplicating a part of the network after the dropout layer while sharing the weights among the duplicated fully connected layers. Experimental results using image classification tasks including ImageNet, CIFAR-10, and CIFAR-100 showed that multi-sample dropout accelerates training. Moreover, the networks trained using multi-sample dropout achieved lower error rates compared to networks trained with the original dropout. The additional computation cost due to the duplicated operations is not significant for deep convolutional networks because most of the computation time is consumed in the convolution layers before the dropout layer, which are not duplicated.

Vision-language models can connect the text description of an object to its specific location in an image through visual grounding. This has potential applications in enhanced radiology reporting. However, these models require large annotated image-text datasets, which are lacking for PET/CT. We developed an automated pipeline to generate weak labels linking PET/CT report descriptions to their image locations and used it to train a 3D vision-language visual grounding model. Our pipeline finds positive findings in PET/CT reports by identifying mentions of SUVmax and axial slice numbers. From 25,578 PET/CT exams, we extracted 11,356 sentence-label pairs. Using this data, we trained ConTEXTual Net 3D, which integrates text embeddings from a large language model with a 3D nnU-Net via token-level cross-attention. The model's performance was compared against LLMSeg, a 2.5D version of ConTEXTual Net, and two nuclear medicine physicians. The weak-labeling pipeline accurately identified lesion locations in 98% of cases (246/251), with 7.5% requiring boundary adjustments. ConTEXTual Net 3D achieved an F1 score of 0.80, outperforming LLMSeg (F1=0.22) and the 2.5D model (F1=0.53), though it underperformed both physicians (F1=0.94 and 0.91). The model achieved better performance on FDG (F1=0.78) and DCFPyL (F1=0.75) exams, while performance dropped on DOTATE (F1=0.58) and Fluciclovine (F1=0.66). The model performed consistently across lesion sizes but showed reduced accuracy on lesions with low uptake. Our novel weak labeling pipeline accurately produced an annotated dataset of PET/CT image-text pairs, facilitating the development of 3D visual grounding models. ConTEXTual Net 3D significantly outperformed other models but fell short of the performance of nuclear medicine physicians. Our study suggests that even larger datasets may be needed to close this performance gap.

Large vision-language models (LVLMs) demonstrate remarkable capabilities in multimodal tasks but are prone to misinterpreting visual inputs, often resulting in hallucinations and unreliable outputs. To address these challenges, we propose Dropout Decoding, a novel inference-time approach that quantifies the uncertainty of visual tokens and selectively masks uncertain tokens to improve decoding. Our method measures the uncertainty of each visual token by projecting it onto the text space and decomposing it into aleatoric and epistemic components. Specifically, we focus on epistemic uncertainty, which captures perception-related errors more effectively. Inspired by dropout regularization, we introduce uncertainty-guided token dropout, which applies the dropout principle to input visual tokens instead of model parameters, and during inference rather than training. By aggregating predictions from an ensemble of masked decoding contexts, Dropout Decoding robustly mitigates errors arising from visual token misinterpretations. Evaluations on benchmarks including CHAIR, THRONE, and MMBench demonstrate that Dropout Decoding significantly reduces object hallucinations (OH) and enhances both reliability and quality of LVLM outputs across diverse visual contexts.

This paper is concerned with the matching stability problem across different decoder layers in DEtection TRansformers (DETR). We point out that the unstable matching in DETR is caused by a multi-optimization path problem, which is highlighted by the one-to-one matching design in DETR. To address this problem, we show that the most important design is to use and only use positional metrics (like IOU) to supervise classification scores of positive examples. Under the principle, we propose two simple yet effective modifications by integrating positional metrics to DETR's classification loss and matching cost, named position-supervised loss and position-modulated cost. We verify our methods on several DETR variants. Our methods show consistent improvements over baselines. By integrating our methods with DINO, we achieve 50.4 and 51.5 AP on the COCO detection benchmark using ResNet-50 backbones under 12 epochs and 24 epochs training settings, achieving a new record under the same setting. We achieve 63.8 AP on COCO detection test-dev with a Swin-Large backbone. Our code will be made available at https://github.com/IDEA-Research/Stable-DINO.

While diffusion models can learn complex distributions, sampling requires a computationally expensive iterative process. Existing distillation methods enable efficient sampling, but have notable limitations, such as performance degradation with very few sampling steps, reliance on training data access, or mode-seeking optimization that may fail to capture the full distribution. We propose EM Distillation (EMD), a maximum likelihood-based approach that distills a diffusion model to a one-step generator model with minimal loss of perceptual quality. Our approach is derived through the lens of Expectation-Maximization (EM), where the generator parameters are updated using samples from the joint distribution of the diffusion teacher prior and inferred generator latents. We develop a reparametrized sampling scheme and a noise cancellation technique that together stabilizes the distillation process. We further reveal an interesting connection of our method with existing methods that minimize mode-seeking KL. EMD outperforms existing one-step generative methods in terms of FID scores on ImageNet-64 and ImageNet-128, and compares favorably with prior work on distilling text-to-image diffusion models.

Contrastive learning has been attracting much attention for learning unsupervised sentence embeddings. The current state-of-the-art unsupervised method is the unsupervised SimCSE (unsup-SimCSE). Unsup-SimCSE takes dropout as a minimal data augmentation method, and passes the same input sentence to a pre-trained Transformer encoder (with dropout turned on) twice to obtain the two corresponding embeddings to build a positive pair. As the length information of a sentence will generally be encoded into the sentence embeddings due to the usage of position embedding in Transformer, each positive pair in unsup-SimCSE actually contains the same length information. And thus unsup-SimCSE trained with these positive pairs is probably biased, which would tend to consider that sentences of the same or similar length are more similar in semantics. Through statistical observations, we find that unsup-SimCSE does have such a problem. To alleviate it, we apply a simple repetition operation to modify the input sentence, and then pass the input sentence and its modified counterpart to the pre-trained Transformer encoder, respectively, to get the positive pair. Additionally, we draw inspiration from the community of computer vision and introduce a momentum contrast, enlarging the number of negative pairs without additional calculations. The proposed two modifications are applied on positive and negative pairs separately, and build a new sentence embedding method, termed Enhanced Unsup-SimCSE (ESimCSE). We evaluate the proposed ESimCSE on several benchmark datasets w.r.t the semantic text similarity (STS) task. Experimental results show that ESimCSE outperforms the state-of-the-art unsup-SimCSE by an average Spearman correlation of 2.02% on BERT-base.

We propose a conditional positional encoding (CPE) scheme for vision Transformers. Unlike previous fixed or learnable positional encodings, which are pre-defined and independent of input tokens, CPE is dynamically generated and conditioned on the local neighborhood of the input tokens. As a result, CPE can easily generalize to the input sequences that are longer than what the model has ever seen during training. Besides, CPE can keep the desired translation-invariance in the image classification task, resulting in improved performance. We implement CPE with a simple Position Encoding Generator (PEG) to get seamlessly incorporated into the current Transformer framework. Built on PEG, we present Conditional Position encoding Vision Transformer (CPVT). We demonstrate that CPVT has visually similar attention maps compared to those with learned positional encodings and delivers outperforming results. Our code is available at https://github.com/Meituan-AutoML/CPVT .

Recent advances in Graph Neural Networks (GNNs) and Graph Transformers (GTs) have been driven by innovations in architectures and Positional Encodings (PEs), which are critical for augmenting node features and capturing graph topology. PEs are essential for GTs, where topological information would otherwise be lost without message-passing. However, PEs are often tested alongside novel architectures, making it difficult to isolate their effect on established models. To address this, we present a comprehensive benchmark of PEs in a unified framework that includes both message-passing GNNs and GTs. We also establish theoretical connections between MPNNs and GTs and introduce a sparsified GRIT attention mechanism to examine the influence of global connectivity. Our findings demonstrate that previously untested combinations of GNN architectures and PEs can outperform existing methods and offer a more comprehensive picture of the state-of-the-art. To support future research and experimentation in our framework, we make the code publicly available.

Generative Adversarial Networks (GANs) have shown compelling results in various tasks and applications in recent years. However, mode collapse remains a critical problem in GANs. In this paper, we propose a novel training pipeline to address the mode collapse issue of GANs. Different from existing methods, we propose to generalize the discriminator as feature embedding and maximize the entropy of distributions in the embedding space learned by the discriminator. Specifically, two regularization terms, i.e., Deep Local Linear Embedding (DLLE) and Deep Isometric feature Mapping (DIsoMap), are designed to encourage the discriminator to learn the structural information embedded in the data, such that the embedding space learned by the discriminator can be well-formed. Based on the well-learned embedding space supported by the discriminator, a non-parametric entropy estimator is designed to efficiently maximize the entropy of embedding vectors, playing as an approximation of maximizing the entropy of the generated distribution. By improving the discriminator and maximizing the distance of the most similar samples in the embedding space, our pipeline effectively reduces the mode collapse without sacrificing the quality of generated samples. Extensive experimental results show the effectiveness of our method, which outperforms the GAN baseline, MaF-GAN on CelebA (9.13 vs. 12.43 in FID) and surpasses the recent state-of-the-art energy-based model on the ANIME-FACE dataset (2.80 vs. 2.26 in Inception score). The code is available at https://github.com/HaozheLiu-ST/MEE

Diffusion models have been used extensively for high quality image and video generation tasks. In this paper, we propose a novel conditional diffusion model with spatial attention and latent embedding (cDAL) for medical image segmentation. In cDAL, a convolutional neural network (CNN) based discriminator is used at every time-step of the diffusion process to distinguish between the generated labels and the real ones. A spatial attention map is computed based on the features learned by the discriminator to help cDAL generate more accurate segmentation of discriminative regions in an input image. Additionally, we incorporated a random latent embedding into each layer of our model to significantly reduce the number of training and sampling time-steps, thereby making it much faster than other diffusion models for image segmentation. We applied cDAL on 3 publicly available medical image segmentation datasets (MoNuSeg, Chest X-ray and Hippocampus) and observed significant qualitative and quantitative improvements with higher Dice scores and mIoU over the state-of-the-art algorithms. The source code is publicly available at https://github.com/Hejrati/cDAL/.

Latent diffusion models (LDMs) power state-of-the-art high-resolution generative image models. LDMs learn the data distribution in the latent space of an autoencoder (AE) and produce images by mapping the generated latents into RGB image space using the AE decoder. While this approach allows for efficient model training and sampling, it induces a disconnect between the training of the diffusion model and the decoder, resulting in a loss of detail in the generated images. To remediate this disconnect, we propose to leverage the internal features of the decoder to define a latent perceptual loss (LPL). This loss encourages the models to create sharper and more realistic images. Our loss can be seamlessly integrated with common autoencoders used in latent diffusion models, and can be applied to different generative modeling paradigms such as DDPM with epsilon and velocity prediction, as well as flow matching. Extensive experiments with models trained on three datasets at 256 and 512 resolution show improved quantitative -- with boosts between 6% and 20% in FID -- and qualitative results when using our perceptual loss.

Deep Neural Networks (DNNs) have been a large driver and enabler for AI breakthroughs in recent years. These models have been getting larger in their attempt to become more accurate and tackle new upcoming use-cases, including AR/VR and intelligent assistants. However, the training process of such large models is a costly and time-consuming process, which typically yields a single model to fit all targets. To mitigate this, various techniques have been proposed in the literature, including pruning, sparsification or quantization of the model weights and updates. While able to achieve high compression rates, they often incur computational overheads or accuracy penalties. Alternatively, factorization methods have been leveraged to incorporate low-rank compression in the training process. Similarly, such techniques (e.g.,~SVD) frequently rely on the computationally expensive decomposition of layers and are potentially sub-optimal for non-linear models, such as DNNs. In this work, we take a further step in designing efficient low-rank models and propose Maestro, a framework for trainable low-rank layers. Instead of regularly applying a priori decompositions such as SVD, the low-rank structure is built into the training process through a generalized variant of Ordered Dropout. This method imposes an importance ordering via sampling on the decomposed DNN structure. Our theoretical analysis demonstrates that our method recovers the SVD decomposition of linear mapping on uniformly distributed data and PCA for linear autoencoders. We further apply our technique on DNNs and empirically illustrate that Maestro enables the extraction of lower footprint models that preserve model performance while allowing for graceful accuracy-latency tradeoff for the deployment to devices of different capabilities.

In this paper, we introduce a novel Multi-Modal Contrastive Pre-training Framework that synergistically combines X-rays, electrocardiograms (ECGs), and radiology/cardiology reports. Our approach leverages transformers to encode these diverse modalities into a unified representation space, aiming to enhance diagnostic accuracy and facilitate comprehensive patient assessments. We utilize LoRA-Peft to significantly reduce trainable parameters in the LLM and incorporate recent linear attention dropping strategy in the Vision Transformer(ViT) for smoother attention. Furthermore, we provide novel multimodal attention explanations and retrieval for our model. To the best of our knowledge, we are the first to propose an integrated model that combines X-ray, ECG, and Radiology/Cardiology Report with this approach. By utilizing contrastive loss, MoRE effectively aligns modality-specific features into a coherent embedding, which supports various downstream tasks such as zero-shot classification and multimodal retrieval. Employing our proposed methodology, we achieve state-of-the-art (SOTA) on the Mimic-IV, CheXpert, Edema Severity, and PtbXl downstream datasets, surpassing existing multimodal approaches. Our proposed framework shows significant improvements in capturing intricate inter-modal relationships and its robustness in medical diagnosis that establishes a framework for future research in multimodal learning in the healthcare sector.

Recent studies have introduced a new class of generative models for synthesizing implicit neural representations (INRs) that capture arbitrary continuous signals in various domains. These models opened the door for domain-agnostic generative models, but they often fail to achieve high-quality generation. We observed that the existing methods generate the weights of neural networks to parameterize INRs and evaluate the network with fixed positional embeddings (PEs). Arguably, this architecture limits the expressive power of generative models and results in low-quality INR generation. To address this limitation, we propose Domain-agnostic Latent Diffusion Model for INRs (DDMI) that generates adaptive positional embeddings instead of neural networks' weights. Specifically, we develop a Discrete-to-continuous space Variational AutoEncoder (D2C-VAE), which seamlessly connects discrete data and the continuous signal functions in the shared latent space. Additionally, we introduce a novel conditioning mechanism for evaluating INRs with the hierarchically decomposed PEs to further enhance expressive power. Extensive experiments across four modalities, e.g., 2D images, 3D shapes, Neural Radiance Fields, and videos, with seven benchmark datasets, demonstrate the versatility of DDMI and its superior performance compared to the existing INR generative models.

Fine-grained classification often requires recognizing specific object parts, such as beak shape and wing patterns for birds. Encouraging a fine-grained classification model to first detect such parts and then using them to infer the class could help us gauge whether the model is indeed looking at the right details better than with interpretability methods that provide a single attribution map. We propose PDiscoNet to discover object parts by using only image-level class labels along with priors encouraging the parts to be: discriminative, compact, distinct from each other, equivariant to rigid transforms, and active in at least some of the images. In addition to using the appropriate losses to encode these priors, we propose to use part-dropout, where full part feature vectors are dropped at once to prevent a single part from dominating in the classification, and part feature vector modulation, which makes the information coming from each part distinct from the perspective of the classifier. Our results on CUB, CelebA, and PartImageNet show that the proposed method provides substantially better part discovery performance than previous methods while not requiring any additional hyper-parameter tuning and without penalizing the classification performance. The code is available at https://github.com/robertdvdk/part_detection.

In the domain of medical imaging, many supervised learning based methods for segmentation face several challenges such as high variability in annotations from multiple experts, paucity of labelled data and class imbalanced datasets. These issues may result in segmentations that lack the requisite precision for clinical analysis and can be misleadingly overconfident without associated uncertainty quantification. We propose the PULASki for biomedical image segmentation that accurately captures variability in expert annotations, even in small datasets. Our approach makes use of an improved loss function based on statistical distances in a conditional variational autoencoder structure (Probabilistic UNet), which improves learning of the conditional decoder compared to the standard cross-entropy particularly in class imbalanced problems. We analyse our method for two structurally different segmentation tasks (intracranial vessel and multiple sclerosis (MS) lesion) and compare our results to four well-established baselines in terms of quantitative metrics and qualitative output. Empirical results demonstrate the PULASKi method outperforms all baselines at the 5\% significance level. The generated segmentations are shown to be much more anatomically plausible than in the 2D case, particularly for the vessel task. Our method can also be applied to a wide range of multi-label segmentation tasks and and is useful for downstream tasks such as hemodynamic modelling (computational fluid dynamics and data assimilation), clinical decision making, and treatment planning.

As large language models (LLMs) become increasingly deployed across various industries, concerns regarding their reliability, particularly due to hallucinations-outputs that are factually inaccurate or irrelevant to user input-have grown. Our research investigates the relationship between the training process and the emergence of hallucinations to address a key gap in existing research that focuses primarily on post hoc detection and mitigation strategies. Using models from the Pythia suite (70M-12B parameters) and several hallucination detection metrics, we analyze hallucination trends throughout training and explore LLM internal dynamics. We introduce SEnsitive Neuron Dropout (SeND), a novel training protocol designed to mitigate hallucinations by reducing variance during training. SeND achieves this by deterministically dropping neurons with significant variability on a dataset, referred to as Sensitive Neurons. In addition, we develop an unsupervised hallucination detection metric, Efficient EigenScore (EES), which approximates the traditional EigenScore in 2x speed. This efficient metric is integrated into our protocol, allowing SeND to be both computationally scalable and effective at reducing hallucinations. Our empirical evaluation demonstrates that our approach improves LLM reliability at test time by up to 40% compared to normal training while also providing an efficient method to improve factual accuracy when adapting LLMs to domains such as Wikipedia and Medical datasets.

Recent empirical works have successfully used unlabeled data to learn feature representations that are broadly useful in downstream classification tasks. Several of these methods are reminiscent of the well-known word2vec embedding algorithm: leveraging availability of pairs of semantically "similar" data points and "negative samples," the learner forces the inner product of representations of similar pairs with each other to be higher on average than with negative samples. The current paper uses the term contrastive learning for such algorithms and presents a theoretical framework for analyzing them by introducing latent classes and hypothesizing that semantically similar points are sampled from the same latent class. This framework allows us to show provable guarantees on the performance of the learned representations on the average classification task that is comprised of a subset of the same set of latent classes. Our generalization bound also shows that learned representations can reduce (labeled) sample complexity on downstream tasks. We conduct controlled experiments in both the text and image domains to support the theory.

Relative position encoding (RPE) is important for transformer to capture sequence ordering of input tokens. General efficacy has been proven in natural language processing. However, in computer vision, its efficacy is not well studied and even remains controversial, e.g., whether relative position encoding can work equally well as absolute position? In order to clarify this, we first review existing relative position encoding methods and analyze their pros and cons when applied in vision transformers. We then propose new relative position encoding methods dedicated to 2D images, called image RPE (iRPE). Our methods consider directional relative distance modeling as well as the interactions between queries and relative position embeddings in self-attention mechanism. The proposed iRPE methods are simple and lightweight. They can be easily plugged into transformer blocks. Experiments demonstrate that solely due to the proposed encoding methods, DeiT and DETR obtain up to 1.5% (top-1 Acc) and 1.3% (mAP) stable improvements over their original versions on ImageNet and COCO respectively, without tuning any extra hyperparameters such as learning rate and weight decay. Our ablation and analysis also yield interesting findings, some of which run counter to previous understanding. Code and models are open-sourced at https://github.com/microsoft/Cream/tree/main/iRPE.

Motivated by the Parameter-Efficient Fine-Tuning (PEFT) in large language models, we propose LoRAT, a method that unveils the power of large ViT model for tracking within laboratory-level resources. The essence of our work lies in adapting LoRA, a technique that fine-tunes a small subset of model parameters without adding inference latency, to the domain of visual tracking. However, unique challenges and potential domain gaps make this transfer not as easy as the first intuition. Firstly, a transformer-based tracker constructs unshared position embedding for template and search image. This poses a challenge for the transfer of LoRA, usually requiring consistency in the design when applied to the pre-trained backbone, to downstream tasks. Secondly, the inductive bias inherent in convolutional heads diminishes the effectiveness of parameter-efficient fine-tuning in tracking models. To overcome these limitations, we first decouple the position embeddings in transformer-based trackers into shared spatial ones and independent type ones. The shared embeddings, which describe the absolute coordinates of multi-resolution images (namely, the template and search images), are inherited from the pre-trained backbones. In contrast, the independent embeddings indicate the sources of each token and are learned from scratch. Furthermore, we design an anchor-free head solely based on MLP to adapt PETR, enabling better performance with less computational overhead. With our design, 1) it becomes practical to train trackers with the ViT-g backbone on GPUs with only memory of 25.8GB (batch size of 16); 2) we reduce the training time of the L-224 variant from 35.0 to 10.8 GPU hours; 3) we improve the LaSOT SUC score from 0.703 to 0.742 with the L-224 variant; 4) we fast the inference speed of the L-224 variant from 52 to 119 FPS. Code and models are available at https://github.com/LitingLin/LoRAT.

Self-supervised learning (SSL) approaches have recently shown substantial success in learning visual representations from unannotated images. Compared with photographic images, medical images acquired with the same imaging protocol exhibit high consistency in anatomy. To exploit this anatomical consistency, this paper introduces a novel SSL approach, called PEAC (patch embedding of anatomical consistency), for medical image analysis. Specifically, in this paper, we propose to learn global and local consistencies via stable grid-based matching, transfer pre-trained PEAC models to diverse downstream tasks, and extensively demonstrate that (1) PEAC achieves significantly better performance than the existing state-of-the-art fully/self-supervised methods, and (2) PEAC captures the anatomical structure consistency across views of the same patient and across patients of different genders, weights, and healthy statuses, which enhances the interpretability of our method for medical image analysis.

Medical phrase grounding (MPG) aims to locate the most relevant region in a medical image, given a phrase query describing certain medical findings, which is an important task for medical image analysis and radiological diagnosis. However, existing visual grounding methods rely on general visual features for identifying objects in natural images and are not capable of capturing the subtle and specialized features of medical findings, leading to sub-optimal performance in MPG. In this paper, we propose MedRPG, an end-to-end approach for MPG. MedRPG is built on a lightweight vision-language transformer encoder and directly predicts the box coordinates of mentioned medical findings, which can be trained with limited medical data, making it a valuable tool in medical image analysis. To enable MedRPG to locate nuanced medical findings with better region-phrase correspondences, we further propose Tri-attention Context contrastive alignment (TaCo). TaCo seeks context alignment to pull both the features and attention outputs of relevant region-phrase pairs close together while pushing those of irrelevant regions far away. This ensures that the final box prediction depends more on its finding-specific regions and phrases. Experimental results on three MPG datasets demonstrate that our MedRPG outperforms state-of-the-art visual grounding approaches by a large margin. Additionally, the proposed TaCo strategy is effective in enhancing finding localization ability and reducing spurious region-phrase correlations.

Instance embeddings are an efficient and versatile image representation that facilitates applications like recognition, verification, retrieval, and clustering. Many metric learning methods represent the input as a single point in the embedding space. Often the distance between points is used as a proxy for match confidence. However, this can fail to represent uncertainty arising when the input is ambiguous, e.g., due to occlusion or blurriness. This work addresses this issue and explicitly models the uncertainty by hedging the location of each input in the embedding space. We introduce the hedged instance embedding (HIB) in which embeddings are modeled as random variables and the model is trained under the variational information bottleneck principle. Empirical results on our new N-digit MNIST dataset show that our method leads to the desired behavior of hedging its bets across the embedding space upon encountering ambiguous inputs. This results in improved performance for image matching and classification tasks, more structure in the learned embedding space, and an ability to compute a per-exemplar uncertainty measure that is correlated with downstream performance.

Vision-language pre-training (VLP) models have shown significant advancements in the medical domain. Yet, most VLP models align raw reports to images at a very coarse level, without modeling fine-grained relationships between anatomical and pathological concepts outlined in reports and the corresponding semantic counterparts in images. To address this problem, we propose a Medical Dual-Stream Language-Image Pre-training (MeDSLIP) framework. Specifically, MeDSLIP establishes vision-language fine-grained alignments via disentangling visual and textual representations into anatomy-relevant and pathology-relevant streams. Moreover, a novel vision-language Prototypical Contr-astive Learning (ProtoCL) method is adopted in MeDSLIP to enhance the alignment within the anatomical and pathological streams. MeDSLIP further employs cross-stream Intra-image Contrastive Learning (ICL) to ensure the consistent coexistence of paired anatomical and pathological concepts within the same image. Such a cross-stream regularization encourages the model to exploit the synchrony between two streams for a more comprehensive representation learning. MeDSLIP is evaluated under zero-shot and supervised fine-tuning settings on three public datasets: NIH CXR14, RSNA Pneumonia, and SIIM-ACR Pneumothorax. Under these settings, MeDSLIP outperforms six leading CNN-based models on classification, grounding, and segmentation tasks.

Consistency models (CMs) are a powerful class of diffusion-based generative models optimized for fast sampling. Most existing CMs are trained using discretized timesteps, which introduce additional hyperparameters and are prone to discretization errors. While continuous-time formulations can mitigate these issues, their success has been limited by training instability. To address this, we propose a simplified theoretical framework that unifies previous parameterizations of diffusion models and CMs, identifying the root causes of instability. Based on this analysis, we introduce key improvements in diffusion process parameterization, network architecture, and training objectives. These changes enable us to train continuous-time CMs at an unprecedented scale, reaching 1.5B parameters on ImageNet 512x512. Our proposed training algorithm, using only two sampling steps, achieves FID scores of 2.06 on CIFAR-10, 1.48 on ImageNet 64x64, and 1.88 on ImageNet 512x512, narrowing the gap in FID scores with the best existing diffusion models to within 10%.

Zero-shot anomaly detection (ZSAD) methods entail detecting anomalies directly without access to any known normal or abnormal samples within the target item categories. Existing approaches typically rely on the robust generalization capabilities of multimodal pretrained models, computing similarities between manually crafted textual features representing "normal" or "abnormal" semantics and image features to detect anomalies and localize anomalous patches. However, the generic descriptions of "abnormal" often fail to precisely match diverse types of anomalies across different object categories. Additionally, computing feature similarities for single patches struggles to pinpoint specific locations of anomalies with various sizes and scales. To address these issues, we propose a novel ZSAD method called FiLo, comprising two components: adaptively learned Fine-Grained Description (FG-Des) and position-enhanced High-Quality Localization (HQ-Loc). FG-Des introduces fine-grained anomaly descriptions for each category using Large Language Models (LLMs) and employs adaptively learned textual templates to enhance the accuracy and interpretability of anomaly detection. HQ-Loc, utilizing Grounding DINO for preliminary localization, position-enhanced text prompts, and Multi-scale Multi-shape Cross-modal Interaction (MMCI) module, facilitates more accurate localization of anomalies of different sizes and shapes. Experimental results on datasets like MVTec and VisA demonstrate that FiLo significantly improves the performance of ZSAD in both detection and localization, achieving state-of-the-art performance with an image-level AUC of 83.9% and a pixel-level AUC of 95.9% on the VisA dataset. Code is available at https://github.com/CASIA-IVA-Lab/FiLo.

Latent diffusion models (LDMs) have made significant advancements in the field of image generation in recent years. One major advantage of LDMs is their ability to operate in a compressed latent space, allowing for more efficient training and deployment. However, despite these advantages, challenges with LDMs still remain. For example, it has been observed that LDMs often generate high-frequency details and complex compositions imperfectly. We hypothesize that one reason for these flaws is due to the fact that all pre- and post-training of LDMs are done in latent space, which is typically 8 times 8 lower spatial-resolution than the output images. To address this issue, we propose adding pixel-space supervision in the post-training process to better preserve high-frequency details. Experimentally, we show that adding a pixel-space objective significantly improves both supervised quality fine-tuning and preference-based post-training by a large margin on a state-of-the-art DiT transformer and U-Net diffusion models in both visual quality and visual flaw metrics, while maintaining the same text alignment quality.

We delve into a nuanced but significant challenge inherent to Vision Transformers (ViTs): feature maps of these models exhibit grid-like artifacts, which detrimentally hurt the performance of ViTs in downstream tasks. Our investigations trace this fundamental issue down to the positional embeddings at the input stage. To address this, we propose a novel noise model, which is universally applicable to all ViTs. Specifically, the noise model dissects ViT outputs into three components: a semantics term free from noise artifacts and two artifact-related terms that are conditioned on pixel locations. Such a decomposition is achieved by enforcing cross-view feature consistency with neural fields in a per-image basis. This per-image optimization process extracts artifact-free features from raw ViT outputs, providing clean features for offline applications. Expanding the scope of our solution to support online functionality, we introduce a learnable denoiser to predict artifact-free features directly from unprocessed ViT outputs, which shows remarkable generalization capabilities to novel data without the need for per-image optimization. Our two-stage approach, termed Denoising Vision Transformers (DVT), does not require re-training existing pre-trained ViTs and is immediately applicable to any Transformer-based architecture. We evaluate our method on a variety of representative ViTs (DINO, MAE, DeiT-III, EVA02, CLIP, DINOv2, DINOv2-reg). Extensive evaluations demonstrate that our DVT consistently and significantly improves existing state-of-the-art general-purpose models in semantic and geometric tasks across multiple datasets (e.g., +3.84 mIoU). We hope our study will encourage a re-evaluation of ViT design, especially regarding the naive use of positional embeddings.

Background. Fully automatic analysis of myocardial perfusion MRI datasets enables rapid and objective reporting of stress/rest studies in patients with suspected ischemic heart disease. Developing deep learning techniques that can analyze multi-center datasets despite limited training data and variations in software and hardware is an ongoing challenge. Methods. Datasets from 3 medical centers acquired at 3T (n = 150 subjects) were included: an internal dataset (inD; n = 95) and two external datasets (exDs; n = 55) used for evaluating the robustness of the trained deep neural network (DNN) models against differences in pulse sequence (exD-1) and scanner vendor (exD-2). A subset of inD (n = 85) was used for training/validation of a pool of DNNs for segmentation, all using the same spatiotemporal U-Net architecture and hyperparameters but with different parameter initializations. We employed a space-time sliding-patch analysis approach that automatically yields a pixel-wise "uncertainty map" as a byproduct of the segmentation process. In our approach, a given test case is segmented by all members of the DNN pool and the resulting uncertainty maps are leveraged to automatically select the "best" one among the pool of solutions. Results. The proposed DAUGS analysis approach performed similarly to the established approach on the internal dataset (p = n.s.) whereas it significantly outperformed on the external datasets (p < 0.005 for exD-1 and exD-2). Moreover, the number of image series with "failed" segmentation was significantly lower for the proposed vs. the established approach (4.3% vs. 17.1%, p < 0.0005). Conclusions. The proposed DAUGS analysis approach has the potential to improve the robustness of deep learning methods for segmentation of multi-center stress perfusion datasets with variations in the choice of pulse sequence, site location or scanner vendor.

Accurate medical classification requires a large number of multi-modal data, and in many cases, different feature types. Previous studies have shown promising results when using multi-modal data, outperforming single-modality models when classifying diseases such as Alzheimer's Disease (AD). However, those models are usually not flexible enough to handle missing modalities. Currently, the most common workaround is discarding samples with missing modalities which leads to considerable data under-utilization. Adding to the fact that labeled medical images are already scarce, the performance of data-driven methods like deep learning can be severely hampered. Therefore, a multi-modal method that can handle missing data in various clinical settings is highly desirable. In this paper, we present Multi-Modal Mixing Transformer (3MAT), a disease classification transformer that not only leverages multi-modal data but also handles missing data scenarios. In this work, we test 3MT for AD and Cognitively normal (CN) classification and mild cognitive impairment (MCI) conversion prediction to progressive MCI (pMCI) or stable MCI (sMCI) using clinical and neuroimaging data. The model uses a novel Cascaded Modality Transformer architecture with cross-attention to incorporate multi-modal information for more informed predictions. We propose a novel modality dropout mechanism to ensure an unprecedented level of modality independence and robustness to handle missing data scenarios. The result is a versatile network that enables the mixing of arbitrary numbers of modalities with different feature types and also ensures full data utilization missing data scenarios. The model is trained and evaluated on the ADNI dataset with the SOTRA performance and further evaluated with the AIBL dataset with missing data.

Bayesian Inference offers principled tools to tackle many critical problems with modern neural networks such as poor calibration and generalization, and data inefficiency. However, scaling Bayesian inference to large architectures is challenging and requires restrictive approximations. Monte Carlo Dropout has been widely used as a relatively cheap way for approximate Inference and to estimate uncertainty with deep neural networks. Traditionally, the dropout mask is sampled independently from a fixed distribution. Recent works show that the dropout mask can be viewed as a latent variable, which can be inferred with variational inference. These methods face two important challenges: (a) the posterior distribution over masks can be highly multi-modal which can be difficult to approximate with standard variational inference and (b) it is not trivial to fully utilize sample-dependent information and correlation among dropout masks to improve posterior estimation. In this work, we propose GFlowOut to address these issues. GFlowOut leverages the recently proposed probabilistic framework of Generative Flow Networks (GFlowNets) to learn the posterior distribution over dropout masks. We empirically demonstrate that GFlowOut results in predictive distributions that generalize better to out-of-distribution data, and provide uncertainty estimates which lead to better performance in downstream tasks.

Joint-embedding predictive architectures (JEPAs) have shown substantial promise in self-supervised representation learning, yet their application in generative modeling remains underexplored. Conversely, diffusion models have demonstrated significant efficacy in modeling arbitrary probability distributions. In this paper, we introduce Denoising with a Joint-Embedding Predictive Architecture (D-JEPA), pioneering the integration of JEPA within generative modeling. By recognizing JEPA as a form of masked image modeling, we reinterpret it as a generalized next-token prediction strategy, facilitating data generation in an auto-regressive manner. Furthermore, we incorporate diffusion loss to model the per-token probability distribution, enabling data generation in a continuous space. We also adapt flow matching loss as an alternative to diffusion loss, thereby enhancing the flexibility of D-JEPA. Empirically, with increased GFLOPs, D-JEPA consistently achieves lower FID scores with fewer training epochs, indicating its good scalability. Our base, large, and huge models outperform all previous generative models across all scales on class-conditional ImageNet benchmarks. Beyond image generation, D-JEPA is well-suited for other continuous data modeling, including video and audio.

The use of positional embeddings in transformer language models is widely accepted. However, recent research has called into question the necessity of such embeddings. We further extend this inquiry by demonstrating that a randomly initialized and frozen transformer language model, devoid of positional embeddings, inherently encodes strong positional information through the shrinkage of self-attention variance. To quantify this variance, we derive the underlying distribution of each step within a transformer layer. Through empirical validation using a fully pretrained model, we show that the variance shrinkage effect still persists after extensive gradient updates. Our findings serve to justify the decision to discard positional embeddings and thus facilitate more efficient pretraining of transformer language models.

In this paper, we study the problem of learning image classification models in the presence of label noise. We revisit a simple compression regularization named Nested Dropout. We find that Nested Dropout, though originally proposed to perform fast information retrieval and adaptive data compression, can properly regularize a neural network to combat label noise. Moreover, owing to its simplicity, it can be easily combined with Co-teaching to further boost the performance. Our final model remains simple yet effective: it achieves comparable or even better performance than the state-of-the-art approaches on two real-world datasets with label noise which are Clothing1M and ANIMAL-10N. On Clothing1M, our approach obtains 74.9% accuracy which is slightly better than that of DivideMix. On ANIMAL-10N, we achieve 84.1% accuracy while the best public result by PLC is 83.4%. We hope that our simple approach can be served as a strong baseline for learning with label noise. Our implementation is available at https://github.com/yingyichen-cyy/Nested-Co-teaching.

Transfer learning has become crucial in computer vision tasks due to the vast availability of pre-trained deep learning models. However, selecting the optimal pre-trained model from a diverse pool for a specific downstream task remains a challenge. Existing methods for measuring the transferability of pre-trained models rely on statistical correlations between encoded static features and task labels, but they overlook the impact of underlying representation dynamics during fine-tuning, leading to unreliable results, especially for self-supervised models. In this paper, we present an insightful physics-inspired approach named PED to address these challenges. We reframe the challenge of model selection through the lens of potential energy and directly model the interaction forces that influence fine-tuning dynamics. By capturing the motion of dynamic representations to decline the potential energy within a force-driven physical model, we can acquire an enhanced and more stable observation for estimating transferability. The experimental results on 10 downstream tasks and 12 self-supervised models demonstrate that our approach can seamlessly integrate into existing ranking techniques and enhance their performances, revealing its effectiveness for the model selection task and its potential for understanding the mechanism in transfer learning. Code will be available at https://github.com/lixiaotong97/PED.

Conventional class-guided diffusion models generally succeed in generating images with correct semantic content, but often struggle with texture details. This limitation stems from the usage of class priors, which only provide coarse and limited conditional information. To address this issue, we propose Diffusion on Diffusion (DoD), an innovative multi-stage generation framework that first extracts visual priors from previously generated samples, then provides rich guidance for the diffusion model leveraging visual priors from the early stages of diffusion sampling. Specifically, we introduce a latent embedding module that employs a compression-reconstruction approach to discard redundant detail information from the conditional samples in each stage, retaining only the semantic information for guidance. We evaluate DoD on the popular ImageNet-256 times 256 dataset, reducing 7times training cost compared to SiT and DiT with even better performance in terms of the FID-50K score. Our largest model DoD-XL achieves an FID-50K score of 1.83 with only 1 million training steps, which surpasses other state-of-the-art methods without bells and whistles during inference.

We present a simple but effective pixel-level self-supervised distillation framework friendly to dense prediction tasks. Our method, called Pixel-Wise Contrastive Distillation (PCD), distills knowledge by attracting the corresponding pixels from student's and teacher's output feature maps. PCD includes a novel design called SpatialAdaptor which ``reshapes'' a part of the teacher network while preserving the distribution of its output features. Our ablation experiments suggest that this reshaping behavior enables more informative pixel-to-pixel distillation. Moreover, we utilize a plug-in multi-head self-attention module that explicitly relates the pixels of student's feature maps to enhance the effective receptive field, leading to a more competitive student. PCD outperforms previous self-supervised distillation methods on various dense prediction tasks. A backbone of ResNet-18-FPN distilled by PCD achieves 37.4 AP^bbox and 34.0 AP^mask on COCO dataset using the detector of Mask R-CNN. We hope our study will inspire future research on how to pre-train a small model friendly to dense prediction tasks in a self-supervised fashion.

Attention Deficit Hyperactive Disorder (ADHD) is a common behavioral problem affecting children. In this work, we investigate the automatic classification of ADHD subjects using the resting state Functional Magnetic Resonance Imaging (fMRI) sequences of the brain. We show that the brain can be modeled as a functional network, and certain properties of the networks differ in ADHD subjects from control subjects. We compute the pairwise correlation of brain voxels' activity over the time frame of the experimental protocol which helps to model the function of a brain as a network. Different network features are computed for each of the voxels constructing the network. The concatenation of the network features of all the voxels in a brain serves as the feature vector. Feature vectors from a set of subjects are then used to train a PCA-LDA (principal component analysis-linear discriminant analysis) based classifier. We hypothesized that ADHD-related differences lie in some specific regions of the brain and using features only from those regions is sufficient to discriminate ADHD and control subjects. We propose a method to create a brain mask that includes the useful regions only and demonstrate that using the feature from the masked regions improves classification accuracy on the test data set. We train our classifier with 776 subjects and test on 171 subjects provided by The Neuro Bureau for the ADHD-200 challenge. We demonstrate the utility of graph-motif features, specifically the maps that represent the frequency of participation of voxels in network cycles of length 3. The best classification performance (69.59%) is achieved using 3-cycle map features with masking. Our proposed approach holds promise in being able to diagnose and understand the disorder.

Text-to-image (T2I) models can effectively capture the content or style of reference images to perform high-quality customization. A representative technique for this is fine-tuning using low-rank adaptations (LoRA), which enables efficient model customization with reference images. However, fine-tuning with a limited number of reference images often leads to overfitting, resulting in issues such as prompt misalignment or content leakage. These issues prevent the model from accurately following the input prompt or generating undesired objects during inference. To address this problem, we examine the text embeddings that guide the diffusion model during inference. This study decomposes the text embedding matrix and conducts a component analysis to understand the embedding space geometry and identify the cause of overfitting. Based on this, we propose DECOR, which projects text embeddings onto a vector space orthogonal to undesired token vectors, thereby reducing the influence of unwanted semantics in the text embeddings. Experimental results demonstrate that DECOR outperforms state-of-the-art customization models and achieves Pareto frontier performance across text and visual alignment evaluation metrics. Furthermore, it generates images more faithful to the input prompts, showcasing its effectiveness in addressing overfitting and enhancing text-to-image customization.

Vision-language models (VLMs) embed aligned image-text pairs into a joint space but often rely on deterministic embeddings, assuming a one-to-one correspondence between images and texts. This oversimplifies real-world relationships, which are inherently many-to-many, with multiple captions describing a single image and vice versa. We introduce Probabilistic Language-Image Pre-training (ProLIP), the first probabilistic VLM pre-trained on a billion-scale image-text dataset using only probabilistic objectives, achieving a strong zero-shot capability (e.g., 74.6% ImageNet zero-shot accuracy with ViT-B/16). ProLIP efficiently estimates uncertainty by an "uncertainty token" without extra parameters. We also introduce a novel inclusion loss that enforces distributional inclusion relationships between image-text pairs and between original and masked inputs. Experiments demonstrate that, by leveraging uncertainty estimates, ProLIP benefits downstream tasks and aligns with intuitive notions of uncertainty, e.g., shorter texts being more uncertain and more general inputs including specific ones. Utilizing text uncertainties, we further improve ImageNet accuracy from 74.6% to 75.8% (under a few-shot setting), supporting the practical advantages of our probabilistic approach. The code is available at https://github.com/naver-ai/prolip

Recent studies have shown that the denoising process in (generative) diffusion models can induce meaningful (discriminative) representations inside the model, though the quality of these representations still lags behind those learned through recent self-supervised learning methods. We argue that one main bottleneck in training large-scale diffusion models for generation lies in effectively learning these representations. Moreover, training can be made easier by incorporating high-quality external visual representations, rather than relying solely on the diffusion models to learn them independently. We study this by introducing a straightforward regularization called REPresentation Alignment (REPA), which aligns the projections of noisy input hidden states in denoising networks with clean image representations obtained from external, pretrained visual encoders. The results are striking: our simple strategy yields significant improvements in both training efficiency and generation quality when applied to popular diffusion and flow-based transformers, such as DiTs and SiTs. For instance, our method can speed up SiT training by over 17.5times, matching the performance (without classifier-free guidance) of a SiT-XL model trained for 7M steps in less than 400K steps. In terms of final generation quality, our approach achieves state-of-the-art results of FID=1.42 using classifier-free guidance with the guidance interval.

We present a neural network architecture designed to naturally learn a positional embedding and overcome the spectral bias towards lower frequencies faced by conventional implicit neural representation networks. Our proposed architecture, SPDER, is a simple MLP that uses an activation function composed of a sinusoidal multiplied by a sublinear function, called the damping function. The sinusoidal enables the network to automatically learn the positional embedding of an input coordinate while the damping passes on the actual coordinate value by preventing it from being projected down to within a finite range of values. Our results indicate that SPDERs speed up training by 10x and converge to losses 1,500-50,000x lower than that of the state-of-the-art for image representation. SPDER is also state-of-the-art in audio representation. The superior representation capability allows SPDER to also excel on multiple downstream tasks such as image super-resolution and video frame interpolation. We provide intuition as to why SPDER significantly improves fitting compared to that of other INR methods while requiring no hyperparameter tuning or preprocessing.

Within the domain of medical analysis, extensive research has explored the potential of mutual learning between Masked Autoencoders(MAEs) and multimodal data. However, the impact of MAEs on intermodality remains a key challenge. We introduce MedFLIP, a Fast Language-Image Pre-training method for Medical analysis. We explore MAEs for zero-shot learning with crossed domains, which enhances the model's ability to learn from limited data, a common scenario in medical diagnostics. We verify that masking an image does not affect inter-modal learning. Furthermore, we propose the SVD loss to enhance the representation learning for characteristics of medical images, aiming to improve classification accuracy by leveraging the structural intricacies of such data. Our theory posits that masking encourages semantic preservation, robust feature extraction, regularization, domain adaptation, and invariance learning. Lastly, we validate using language will improve the zero-shot performance for the medical image analysis. MedFLIP's scaling of the masking process marks an advancement in the field, offering a pathway to rapid and precise medical image analysis without the traditional computational bottlenecks. Through experiments and validation, MedFLIP demonstrates efficient performance improvements, helps for future research and application in medical diagnostics.

Training visual embeddings with labeled data supervision has been the de facto setup for representation learning in computer vision. Inspired by recent success of adopting masked image modeling (MIM) in self-supervised representation learning, we propose a simple yet effective setup that can easily integrate MIM into existing supervised training paradigms. In our design, in addition to the original classification task applied to a vision transformer image encoder, we add a shallow transformer-based decoder on top of the encoder and introduce an MIM task which tries to reconstruct image tokens based on masked image inputs. We show with minimal change in architecture and no overhead in inference that this setup is able to improve the quality of the learned representations for downstream tasks such as classification, image retrieval, and semantic segmentation. We conduct a comprehensive study and evaluation of our setup on public benchmarks. On ImageNet-1k, our ViT-B/14 model achieves 81.72% validation accuracy, 2.01% higher than the baseline model. On K-Nearest-Neighbor image retrieval evaluation with ImageNet-1k, the same model outperforms the baseline by 1.32%. We also show that this setup can be easily scaled to larger models and datasets. Code and checkpoints will be released.

Medical vision-language models enable co-learning and integrating features from medical imaging and clinical text. However, these models are not easy to train and the latent representation space can be complex. Here we propose a novel way for pre-training and regularising medical vision-language models. The proposed method, named Medical vision-language pre-training with Frozen language models and Latent spAce Geometry optimization (M-FLAG), leverages a frozen language model for training stability and efficiency and introduces a novel orthogonality loss to harmonize the latent space geometry. We demonstrate the potential of the pre-trained model on three downstream tasks: medical image classification, segmentation, and object detection. Extensive experiments across five public datasets demonstrate that M-FLAG significantly outperforms existing medical vision-language pre-training approaches and reduces the number of parameters by 78\%. Notably, M-FLAG achieves outstanding performance on the segmentation task while using only 1\% of the RSNA dataset, even outperforming ImageNet pre-trained models that have been fine-tuned using 100\% of the data.

Decoder-only large language model (LLM)-based embedding models are beginning to outperform BERT or T5-based embedding models in general-purpose text embedding tasks, including dense vector-based retrieval. In this work, we introduce the NV-Embed model with a variety of architectural designs and training procedures to significantly enhance the performance of LLM as a versatile embedding model, while maintaining its simplicity and reproducibility. For model architecture, we propose a latent attention layer to obtain pooled embeddings, which consistently improves retrieval and downstream task accuracy compared to mean pooling or using the last <EOS> token embedding from LLMs. To enhance representation learning, we remove the causal attention mask of LLMs during contrastive training. For model training, we introduce a two-stage contrastive instruction-tuning method. It first applies contrastive training with instructions on retrieval datasets, utilizing in-batch negatives and curated hard negative examples. At stage-2, it blends various non-retrieval datasets into instruction tuning, which not only enhances non-retrieval task accuracy but also improves retrieval performance. Combining these techniques, our NV-Embed model, using only publicly available data, has achieved a record-high score of 69.32, ranking No. 1 on the Massive Text Embedding Benchmark (MTEB) (as of May 24, 2024), with 56 tasks, encompassing retrieval, reranking, classification, clustering, and semantic textual similarity tasks. Notably, our model also attains the highest score of 59.36 on 15 retrieval tasks in the MTEB benchmark (also known as BEIR). We will open-source the model at: https://huggingface.co/nvidia/NV-Embed-v1.

Learning similarity is a key aspect in medical image analysis, particularly in recommendation systems or in uncovering the interpretation of anatomical data in images. Most existing methods learn such similarities in the embedding space over image sets using a single metric learner. Images, however, have a variety of object attributes such as color, shape, or artifacts. Encoding such attributes using a single metric learner is inadequate and may fail to generalize. Instead, multiple learners could focus on separate aspects of these attributes in subspaces of an overarching embedding. This, however, implies the number of learners to be found empirically for each new dataset. This work, Dynamic Subspace Learners, proposes to dynamically exploit multiple learners by removing the need of knowing apriori the number of learners and aggregating new subspace learners during training. Furthermore, the visual interpretability of such subspace learning is enforced by integrating an attention module into our method. This integrated attention mechanism provides a visual insight of discriminative image features that contribute to the clustering of image sets and a visual explanation of the embedding features. The benefits of our attention-based dynamic subspace learners are evaluated in the application of image clustering, image retrieval, and weakly supervised segmentation. Our method achieves competitive results with the performances of multiple learners baselines and significantly outperforms the classification network in terms of clustering and retrieval scores on three different public benchmark datasets. Moreover, our attention maps offer a proxy-labels, which improves the segmentation accuracy up to 15% in Dice scores when compared to state-of-the-art interpretation techniques.

Masked Image Modeling (MIM) has emerged as a promising method for deriving visual representations from unlabeled image data by predicting missing pixels from masked portions of images. It excels in region-aware learning and provides strong initializations for various tasks, but struggles to capture high-level semantics without further supervised fine-tuning, likely due to the low-level nature of its pixel reconstruction objective. A promising yet unrealized framework is learning representations through masked reconstruction in latent space, combining the locality of MIM with the high-level targets. However, this approach poses significant training challenges as the reconstruction targets are learned in conjunction with the model, potentially leading to trivial or suboptimal solutions.Our study is among the first to thoroughly analyze and address the challenges of such framework, which we refer to as Latent MIM. Through a series of carefully designed experiments and extensive analysis, we identify the source of these challenges, including representation collapsing for joint online/target optimization, learning objectives, the high region correlation in latent space and decoding conditioning. By sequentially addressing these issues, we demonstrate that Latent MIM can indeed learn high-level representations while retaining the benefits of MIM models.

Automated radiology report generation offers an effective solution to alleviate radiologists' workload. However, most existing methods focus primarily on single or fixed-view images to model current disease conditions, which limits diagnostic accuracy and overlooks disease progression. Although some approaches utilize longitudinal data to track disease progression, they still rely on single images to analyze current visits. To address these issues, we propose enhanced contrastive learning with Multi-view Longitudinal data to facilitate chest X-ray Report Generation, named MLRG. Specifically, we introduce a multi-view longitudinal contrastive learning method that integrates spatial information from current multi-view images and temporal information from longitudinal data. This method also utilizes the inherent spatiotemporal information of radiology reports to supervise the pre-training of visual and textual representations. Subsequently, we present a tokenized absence encoding technique to flexibly handle missing patient-specific prior knowledge, allowing the model to produce more accurate radiology reports based on available prior knowledge. Extensive experiments on MIMIC-CXR, MIMIC-ABN, and Two-view CXR datasets demonstrate that our MLRG outperforms recent state-of-the-art methods, achieving a 2.3% BLEU-4 improvement on MIMIC-CXR, a 5.5% F1 score improvement on MIMIC-ABN, and a 2.7% F1 RadGraph improvement on Two-view CXR.

White matter tract segmentation is crucial for studying brain structural connectivity and neurosurgical planning. However, segmentation remains challenging due to issues like class imbalance between major and minor tracts, structural similarity, subject variability, symmetric streamlines between hemispheres etc. To address these challenges, we propose TractoEmbed, a modular multi-level embedding framework, that encodes localized representations through learning tasks in respective encoders. In this paper, TractoEmbed introduces a novel hierarchical streamline data representation that captures maximum spatial information at each level i.e. individual streamlines, clusters, and patches. Experiments show that TractoEmbed outperforms state-of-the-art methods in white matter tract segmentation across different datasets, and spanning various age groups. The modular framework directly allows the integration of additional embeddings in future works.

The medical domain is vast and diverse, with many existing embedding models focused on general healthcare applications. However, these models often struggle to capture a deep understanding of diseases due to their broad generalization across the entire medical field. To address this gap, I present DisEmbed, a disease-focused embedding model. DisEmbed is trained on a synthetic dataset specifically curated to include disease descriptions, symptoms, and disease-related Q\&A pairs, making it uniquely suited for disease-related tasks. For evaluation, I benchmarked DisEmbed against existing medical models using disease-specific datasets and the triplet evaluation method. My results demonstrate that DisEmbed outperforms other models, particularly in identifying disease-related contexts and distinguishing between similar diseases. This makes DisEmbed highly valuable for disease-specific use cases, including retrieval-augmented generation (RAG) tasks, where its performance is particularly robust.

Image clustering is one of the most important computer vision applications, which has been extensively studied in literature. However, current clustering methods mostly suffer from lack of efficiency and scalability when dealing with large-scale and high-dimensional data. In this paper, we propose a new clustering model, called DEeP Embedded RegularIzed ClusTering (DEPICT), which efficiently maps data into a discriminative embedding subspace and precisely predicts cluster assignments. DEPICT generally consists of a multinomial logistic regression function stacked on top of a multi-layer convolutional autoencoder. We define a clustering objective function using relative entropy (KL divergence) minimization, regularized by a prior for the frequency of cluster assignments. An alternating strategy is then derived to optimize the objective by updating parameters and estimating cluster assignments. Furthermore, we employ the reconstruction loss functions in our autoencoder, as a data-dependent regularization term, to prevent the deep embedding function from overfitting. In order to benefit from end-to-end optimization and eliminate the necessity for layer-wise pretraining, we introduce a joint learning framework to minimize the unified clustering and reconstruction loss functions together and train all network layers simultaneously. Experimental results indicate the superiority and faster running time of DEPICT in real-world clustering tasks, where no labeled data is available for hyper-parameter tuning.

The ability to synthesize personalized group photos and specify the positions of each identity offers immense creative potential. While such imagery can be visually appealing, it presents significant challenges for existing technologies. A persistent issue is identity (ID) leakage, where injected facial features interfere with one another, resulting in low face resemblance, incorrect positioning, and visual artifacts. Existing methods suffer from limitations such as the reliance on segmentation models, increased runtime, or a high probability of ID leakage. To address these challenges, we propose ID-Patch, a novel method that provides robust association between identities and 2D positions. Our approach generates an ID patch and ID embeddings from the same facial features: the ID patch is positioned on the conditional image for precise spatial control, while the ID embeddings integrate with text embeddings to ensure high resemblance. Experimental results demonstrate that ID-Patch surpasses baseline methods across metrics, such as face ID resemblance, ID-position association accuracy, and generation efficiency. Project Page is: https://byteaigc.github.io/ID-Patch/

Generative models serve as powerful tools for modeling the real world, with mainstream diffusion models, particularly those based on the latent diffusion model paradigm, achieving remarkable progress across various tasks, such as image and video synthesis. Latent diffusion models are typically trained using Variational Autoencoders (VAEs), interacting with VAE latents rather than the real samples. While this generative paradigm speeds up training and inference, the quality of the generated outputs is limited by the latents' quality. Traditional VAE latents are often seen as spatial compression in pixel space and lack explicit semantic representations, which are essential for modeling the real world. In this paper, we introduce ReaLS (Representation-Aligned Latent Space), which integrates semantic priors to improve generation performance. Extensive experiments show that fundamental DiT and SiT trained on ReaLS can achieve a 15% improvement in FID metric. Furthermore, the enhanced semantic latent space enables more perceptual downstream tasks, such as segmentation and depth estimation.

In this paper, we present a novel approach for segmenting pediatric brain tumors using a deep learning architecture, inspired by expert radiologists' segmentation strategies. Our model delineates four distinct tumor labels and is benchmarked on a held-out PED BraTS 2024 test set (i.e., pediatric brain tumor datasets introduced by BraTS). Furthermore, we evaluate our model's performance against the state-of-the-art (SOTA) model using a new external dataset of 30 patients from CBTN (Children's Brain Tumor Network), labeled in accordance with the PED BraTS 2024 guidelines and 2023 BraTS Adult Glioma dataset. We compare segmentation outcomes with the winning algorithm from the PED BraTS 2023 challenge as the SOTA model. Our proposed algorithm achieved an average Dice score of 0.642 and an HD95 of 73.0 mm on the CBTN test data, outperforming the SOTA model, which achieved a Dice score of 0.626 and an HD95 of 84.0 mm. Moreover, our model exhibits strong generalizability, attaining a 0.877 Dice score in whole tumor segmentation on the BraTS 2023 Adult Glioma dataset, surpassing existing SOTA. Our results indicate that the proposed model is a step towards providing more accurate segmentation for pediatric brain tumors, which is essential for evaluating therapy response and monitoring patient progress. Our source code is available at https://github.com/NUBagciLab/Pediatric-Brain-Tumor-Segmentation-Model.

Graphs or networks are a very convenient way to represent data with lots of interaction. Recently, Machine Learning on Graph data has gained a lot of traction. In particular, vertex classification and missing edge detection have very interesting applications, ranging from drug discovery to recommender systems. To achieve such tasks, tremendous work has been accomplished to learn embedding of nodes and edges into finite-dimension vector spaces. This task is called Graph Representation Learning. However, Graph Representation Learning techniques often display prohibitive time and memory complexities, preventing their use in real-time with business size graphs. In this paper, we address this issue by leveraging a degeneracy property of Graphs - the K-Core Decomposition. We present two techniques taking advantage of this decomposition to reduce the time and memory consumption of walk-based Graph Representation Learning algorithms. We evaluate the performances, expressed in terms of quality of embedding and computational resources, of the proposed techniques on several academic datasets. Our code is available at https://github.com/SBrandeis/kcore-embedding

Transformers with causal attention can solve tasks that require positional information without using positional encodings. In this work, we propose and investigate a new hypothesis about how positional information can be stored without using explicit positional encoding. We observe that nearby embeddings are more similar to each other than faraway embeddings, allowing the transformer to potentially reconstruct the positions of tokens. We show that this pattern can occur in both the trained and the randomly initialized Transformer models with causal attention and no positional encodings over a common range of hyperparameters.

Weakly supervised object localization (WSOL) remains challenging when learning object localization models from image category labels. Conventional methods that discriminatively train activation models ignore representative yet less discriminative object parts. In this study, we propose a generative prompt model (GenPromp), defining the first generative pipeline to localize less discriminative object parts by formulating WSOL as a conditional image denoising procedure. During training, GenPromp converts image category labels to learnable prompt embeddings which are fed to a generative model to conditionally recover the input image with noise and learn representative embeddings. During inference, enPromp combines the representative embeddings with discriminative embeddings (queried from an off-the-shelf vision-language model) for both representative and discriminative capacity. The combined embeddings are finally used to generate multi-scale high-quality attention maps, which facilitate localizing full object extent. Experiments on CUB-200-2011 and ILSVRC show that GenPromp respectively outperforms the best discriminative models by 5.2% and 5.6% (Top-1 Loc), setting a solid baseline for WSOL with the generative model. Code is available at https://github.com/callsys/GenPromp.

The application of machine learning to medical ultrasound videos of the heart, i.e., echocardiography, has recently gained traction with the availability of large public datasets. Traditional supervised tasks, such as ejection fraction regression, are now making way for approaches focusing more on the latent structure of data distributions, as well as generative methods. We propose a model trained exclusively by knowledge distillation, either on real or synthetical data, involving retrieving masks suggested by a teacher model. We achieve state-of-the-art (SOTA) values on the task of identifying end-diastolic and end-systolic frames. By training the model only on synthetic data, it reaches segmentation capabilities close to the performance when trained on real data with a significantly reduced number of weights. A comparison with the 5 main existing methods shows that our method outperforms the others in most cases. We also present a new evaluation method that does not require human annotation and instead relies on a large auxiliary model. We show that this method produces scores consistent with those obtained from human annotations. Relying on the integrated knowledge from a vast amount of records, this method overcomes certain inherent limitations of human annotator labeling. Code: https://github.com/GregoirePetit/EchoDFKD

Dropout is a widely utilized regularization technique in the training of neural networks, nevertheless, its underlying mechanism and its impact on achieving good generalization abilities remain poorly understood. In this work, we derive the stochastic modified equations for analyzing the dynamics of dropout, where its discrete iteration process is approximated by a class of stochastic differential equations. In order to investigate the underlying mechanism by which dropout facilitates the identification of flatter minima, we study the noise structure of the derived stochastic modified equation for dropout. By drawing upon the structural resemblance between the Hessian and covariance through several intuitive approximations, we empirically demonstrate the universal presence of the inverse variance-flatness relation and the Hessian-variance relation, throughout the training process of dropout. These theoretical and empirical findings make a substantial contribution to our understanding of the inherent tendency of dropout to locate flatter minima.

Limited labeled data makes it hard to train models from scratch in medical domain, and an important paradigm is pre-training and then fine-tuning. Large pre-trained models contain rich representations, which can be adapted to downstream medical tasks. However, existing methods either tune all the parameters or the task-specific layers of the pre-trained models, ignoring the input variations of medical images, and thus they are not efficient or effective. In this work, we aim to study parameter-efficient fine-tuning (PEFT) for medical image analysis, and propose a dynamic visual prompt tuning method, named DVPT. It can extract knowledge beneficial to downstream tasks from large models with a few trainable parameters. Firstly, the frozen features are transformed by an lightweight bottleneck layer to learn the domain-specific distribution of downstream medical tasks, and then a few learnable visual prompts are used as dynamic queries and then conduct cross-attention with the transformed features, attempting to acquire sample-specific knowledge that are suitable for each sample. Finally, the features are projected to original feature dimension and aggregated with the frozen features. This DVPT module can be shared between different Transformer layers, further reducing the trainable parameters. To validate DVPT, we conduct extensive experiments with different pre-trained models on medical classification and segmentation tasks. We find such PEFT method can not only efficiently adapt the pre-trained models to the medical domain, but also brings data efficiency with partial labeled data. For example, with 0.5\% extra trainable parameters, our method not only outperforms state-of-the-art PEFT methods, even surpasses the full fine-tuning by more than 2.20\% Kappa score on medical classification task. It can saves up to 60\% labeled data and 99\% storage cost of ViT-B/16.

This paper proposes a pre-trained neural network for handling event camera data. Our model is a self-supervised learning framework, and uses paired event camera data and natural RGB images for training. Our method contains three modules connected in a sequence: i) a family of event data augmentations, generating meaningful event images for self-supervised training; ii) a conditional masking strategy to sample informative event patches from event images, encouraging our model to capture the spatial layout of a scene and accelerating training; iii) a contrastive learning approach, enforcing the similarity of embeddings between matching event images, and between paired event and RGB images. An embedding projection loss is proposed to avoid the model collapse when enforcing the event image embedding similarities. A probability distribution alignment loss is proposed to encourage the event image to be consistent with its paired RGB image in the feature space. Transfer learning performance on downstream tasks shows the superiority of our method over state-of-the-art methods. For example, we achieve top-1 accuracy at 64.83% on the N-ImageNet dataset.

Tabular neural network (NN) has attracted remarkable attentions and its recent advances have gradually narrowed the performance gap with respect to tree-based models on many public datasets. While the mainstreams focus on calibrating NN to fit tabular data, we emphasize the importance of homogeneous embeddings and alternately concentrate on regularizing tabular inputs through supervised pretraining. Specifically, we extend a recent work (DeepTLF) and utilize the structure of pretrained tree ensembles to transform raw variables into a single vector (T2V), or an array of tokens (T2T). Without loss of space efficiency, these binarized embeddings can be consumed by canonical tabular NN with fully-connected or attention-based building blocks. Through quantitative experiments on 88 OpenML datasets with binary classification task, we validated that the proposed tree-regularized representation not only tapers the difference with respect to tree-based models, but also achieves on-par and better performance when compared with advanced NN models. Most importantly, it possesses better robustness and can be easily scaled and generalized as standalone encoder for tabular modality. Codes: https://github.com/milanlx/tree-regularized-embedding.

What sorts of structure might enable a learner to discover classes from unlabeled data? Traditional approaches rely on feature-space similarity and heroic assumptions on the data. In this paper, we introduce unsupervised learning under Latent Label Shift (LLS), where we have access to unlabeled data from multiple domains such that the label marginals p_d(y) can shift across domains but the class conditionals p(x|y) do not. This work instantiates a new principle for identifying classes: elements that shift together group together. For finite input spaces, we establish an isomorphism between LLS and topic modeling: inputs correspond to words, domains to documents, and labels to topics. Addressing continuous data, we prove that when each label's support contains a separable region, analogous to an anchor word, oracle access to p(d|x) suffices to identify p_d(y) and p_d(y|x) up to permutation. Thus motivated, we introduce a practical algorithm that leverages domain-discriminative models as follows: (i) push examples through domain discriminator p(d|x); (ii) discretize the data by clustering examples in p(d|x) space; (iii) perform non-negative matrix factorization on the discrete data; (iv) combine the recovered p(y|d) with the discriminator outputs p(d|x) to compute p_d(y|x) ; forall d. With semi-synthetic experiments, we show that our algorithm can leverage domain information to improve upon competitive unsupervised classification methods. We reveal a failure mode of standard unsupervised classification methods when feature-space similarity does not indicate true groupings, and show empirically that our method better handles this case. Our results establish a deep connection between distribution shift and topic modeling, opening promising lines for future work.

We introduce Efficient Motion Diffusion Model (EMDM) for fast and high-quality human motion generation. Current state-of-the-art generative diffusion models have produced impressive results but struggle to achieve fast generation without sacrificing quality. On the one hand, previous works, like motion latent diffusion, conduct diffusion within a latent space for efficiency, but learning such a latent space can be a non-trivial effort. On the other hand, accelerating generation by naively increasing the sampling step size, e.g., DDIM, often leads to quality degradation as it fails to approximate the complex denoising distribution. To address these issues, we propose EMDM, which captures the complex distribution during multiple sampling steps in the diffusion model, allowing for much fewer sampling steps and significant acceleration in generation. This is achieved by a conditional denoising diffusion GAN to capture multimodal data distributions among arbitrary (and potentially larger) step sizes conditioned on control signals, enabling fewer-step motion sampling with high fidelity and diversity. To minimize undesired motion artifacts, geometric losses are imposed during network learning. As a result, EMDM achieves real-time motion generation and significantly improves the efficiency of motion diffusion models compared to existing methods while achieving high-quality motion generation. Our code will be publicly available upon publication.

Subject-driven text-to-image generation aims to generate customized images of the given subject based on the text descriptions, which has drawn increasing attention. Existing methods mainly resort to finetuning a pretrained generative model, where the identity-relevant information (e.g., the boy) and the identity-irrelevant information (e.g., the background or the pose of the boy) are entangled in the latent embedding space. However, the highly entangled latent embedding may lead to the failure of subject-driven text-to-image generation as follows: (i) the identity-irrelevant information hidden in the entangled embedding may dominate the generation process, resulting in the generated images heavily dependent on the irrelevant information while ignoring the given text descriptions; (ii) the identity-relevant information carried in the entangled embedding can not be appropriately preserved, resulting in identity change of the subject in the generated images. To tackle the problems, we propose DisenBooth, an identity-preserving disentangled tuning framework for subject-driven text-to-image generation. Specifically, DisenBooth finetunes the pretrained diffusion model in the denoising process. Different from previous works that utilize an entangled embedding to denoise each image, DisenBooth instead utilizes disentangled embeddings to respectively preserve the subject identity and capture the identity-irrelevant information. We further design the novel weak denoising and contrastive embedding auxiliary tuning objectives to achieve the disentanglement. Extensive experiments show that our proposed DisenBooth framework outperforms baseline models for subject-driven text-to-image generation with the identity-preserved embedding. Additionally, by combining the identity-preserved embedding and identity-irrelevant embedding, DisenBooth demonstrates more generation flexibility and controllability

Network embedding, which maps graphs to distributed representations, is a unified framework for various graph inference tasks. According to the topology properties (e.g., structural roles and community memberships of nodes) to be preserved, it can be categorized into the identity and position embedding. However, existing methods can only capture one type of property. Some approaches can support the inductive inference that generalizes the embedding model to new nodes or graphs but relies on the availability of attributes. Due to the complicated correlations between topology and attributes, it is unclear for some inductive methods which type of property they can capture. In this study, we explore a unified framework for the joint inductive inference of identity and position embeddings without attributes. An inductive random walk embedding (IRWE) method is proposed, which combines multiple attention units to handle the random walk on graph topology and simultaneously derives identity and position embeddings that are jointly optimized. In particular, we demonstrate that some random walk statistics can be informative features to characterize node identities and positions while supporting the inductive embedding inference. Experiments validate the superior performance of IRWE beyond various baselines for the transductive and inductive inference of identity and position embeddings.

Because anomalous samples cannot be used for training, many anomaly detection and localization methods use pre-trained networks and non-parametric modeling to estimate encoded feature distribution. However, these methods neglect the impact of position and neighborhood information on the distribution of normal features. To overcome this, we propose a new algorithm, PNI, which estimates the normal distribution using conditional probability given neighborhood features, modeled with a multi-layer perceptron network. Moreover, position information is utilized by creating a histogram of representative features at each position. Instead of simply resizing the anomaly map, the proposed method employs an additional refine network trained on synthetic anomaly images to better interpolate and account for the shape and edge of the input image. We conducted experiments on the MVTec AD benchmark dataset and achieved state-of-the-art performance, with 99.56\% and 98.98\% AUROC scores in anomaly detection and localization, respectively.

Supervised dictionary learning (SDL) is a classical machine learning method that simultaneously seeks feature extraction and classification tasks, which are not necessarily a priori aligned objectives. The goal of SDL is to learn a class-discriminative dictionary, which is a set of latent feature vectors that can well-explain both the features as well as labels of observed data. In this paper, we provide a systematic study of SDL, including the theory, algorithm, and applications of SDL. First, we provide a novel framework that `lifts' SDL as a convex problem in a combined factor space and propose a low-rank projected gradient descent algorithm that converges exponentially to the global minimizer of the objective. We also formulate generative models of SDL and provide global estimation guarantees of the true parameters depending on the hyperparameter regime. Second, viewed as a nonconvex constrained optimization problem, we provided an efficient block coordinate descent algorithm for SDL that is guaranteed to find an varepsilon-stationary point of the objective in O(varepsilon^{-1}(log varepsilon^{-1})^{2}) iterations. For the corresponding generative model, we establish a novel non-asymptotic local consistency result for constrained and regularized maximum likelihood estimation problems, which may be of independent interest. Third, we apply SDL for imbalanced document classification by supervised topic modeling and also for pneumonia detection from chest X-ray images. We also provide simulation studies to demonstrate that SDL becomes more effective when there is a discrepancy between the best reconstructive and the best discriminative dictionaries.

This work examines the challenges of training neural networks using vector quantization using straight-through estimation. We find that a primary cause of training instability is the discrepancy between the model embedding and the code-vector distribution. We identify the factors that contribute to this issue, including the codebook gradient sparsity and the asymmetric nature of the commitment loss, which leads to misaligned code-vector assignments. We propose to address this issue via affine re-parameterization of the code vectors. Additionally, we introduce an alternating optimization to reduce the gradient error introduced by the straight-through estimation. Moreover, we propose an improvement to the commitment loss to ensure better alignment between the codebook representation and the model embedding. These optimization methods improve the mathematical approximation of the straight-through estimation and, ultimately, the model performance. We demonstrate the effectiveness of our methods on several common model architectures, such as AlexNet, ResNet, and ViT, across various tasks, including image classification and generative modeling.

Text-to-image person re-identification (TIReID) is a compelling topic in the cross-modal community, which aims to retrieve the target person based on a textual query. Although numerous TIReID methods have been proposed and achieved promising performance, they implicitly assume the training image-text pairs are correctly aligned, which is not always the case in real-world scenarios. In practice, the image-text pairs inevitably exist under-correlated or even false-correlated, a.k.a noisy correspondence (NC), due to the low quality of the images and annotation errors. To address this problem, we propose a novel Robust Dual Embedding method (RDE) that can learn robust visual-semantic associations even with NC. Specifically, RDE consists of two main components: 1) A Confident Consensus Division (CCD) module that leverages the dual-grained decisions of dual embedding modules to obtain a consensus set of clean training data, which enables the model to learn correct and reliable visual-semantic associations. 2) A Triplet-Alignment Loss (TAL) relaxes the conventional triplet-ranking loss with hardest negatives, which tends to rapidly overfit NC, to a log-exponential upper bound over all negatives, thus preventing the model from overemphasizing false image-text pairs. We conduct extensive experiments on three public benchmarks, namely CUHK-PEDES, ICFG-PEDES, and RSTPReID, to evaluate the performance and robustness of our RDE. Our method achieves state-of-the-art results both with and without synthetic noisy correspondences on all three datasets.

In this article, we focus on decomposing latent representations in generative adversarial networks or learned feature representations in deep autoencoders into semantically controllable factors in a semisupervised manner, without modifying the original trained models. Particularly, we propose factors' decomposer-entangler network (FDEN) that learns to decompose a latent representation into mutually independent factors. Given a latent representation, the proposed framework draws a set of interpretable factors, each aligned to independent factors of variations by minimizing their total correlation in an information-theoretic means. As a plug-in method, we have applied our proposed FDEN to the existing networks of adversarially learned inference and pioneer network and performed computer vision tasks of image-to-image translation in semantic ways, e.g., changing styles, while keeping the identity of a subject, and object classification in a few-shot learning scheme. We have also validated the effectiveness of the proposed method with various ablation studies in the qualitative, quantitative, and statistical examination.

This paper identifies significant redundancy in the query-key interactions within self-attention mechanisms of diffusion transformer models, particularly during the early stages of denoising diffusion steps. In response to this observation, we present a novel diffusion transformer framework incorporating an additional set of mediator tokens to engage with queries and keys separately. By modulating the number of mediator tokens during the denoising generation phases, our model initiates the denoising process with a precise, non-ambiguous stage and gradually transitions to a phase enriched with detail. Concurrently, integrating mediator tokens simplifies the attention module's complexity to a linear scale, enhancing the efficiency of global attention processes. Additionally, we propose a time-step dynamic mediator token adjustment mechanism that further decreases the required computational FLOPs for generation, simultaneously facilitating the generation of high-quality images within the constraints of varied inference budgets. Extensive experiments demonstrate that the proposed method can improve the generated image quality while also reducing the inference cost of diffusion transformers. When integrated with the recent work SiT, our method achieves a state-of-the-art FID score of 2.01. The source code is available at https://github.com/LeapLabTHU/Attention-Mediators.

Vision-language Models (VLMs) have shown remarkable capabilities in advancing general artificial intelligence, yet the irrational encoding of visual positions persists in inhibiting the models' comprehensive perception performance across different levels of granularity. In this work, we propose Pyramid-descent Visual Position Encoding (PyPE), a novel approach designed to enhance the perception of visual tokens within VLMs. By assigning visual position indexes from the periphery to the center and expanding the central receptive field incrementally, PyPE addresses the limitations of traditional raster-scan methods and mitigates the long-term decay effects induced by Rotary Position Embedding (RoPE). Our method reduces the relative distance between interrelated visual elements and instruction tokens, promoting a more rational allocation of attention weights and allowing for a multi-granularity perception of visual elements and countering the over-reliance on anchor tokens. Extensive experimental evaluations demonstrate that PyPE consistently improves the general capabilities of VLMs across various sizes. Code is available at https://github.com/SakuraTroyChen/PyPE.

We present CSWin Transformer, an efficient and effective Transformer-based backbone for general-purpose vision tasks. A challenging issue in Transformer design is that global self-attention is very expensive to compute whereas local self-attention often limits the field of interactions of each token. To address this issue, we develop the Cross-Shaped Window self-attention mechanism for computing self-attention in the horizontal and vertical stripes in parallel that form a cross-shaped window, with each stripe obtained by splitting the input feature into stripes of equal width. We provide a mathematical analysis of the effect of the stripe width and vary the stripe width for different layers of the Transformer network which achieves strong modeling capability while limiting the computation cost. We also introduce Locally-enhanced Positional Encoding (LePE), which handles the local positional information better than existing encoding schemes. LePE naturally supports arbitrary input resolutions, and is thus especially effective and friendly for downstream tasks. Incorporated with these designs and a hierarchical structure, CSWin Transformer demonstrates competitive performance on common vision tasks. Specifically, it achieves 85.4\% Top-1 accuracy on ImageNet-1K without any extra training data or label, 53.9 box AP and 46.4 mask AP on the COCO detection task, and 52.2 mIOU on the ADE20K semantic segmentation task, surpassing previous state-of-the-art Swin Transformer backbone by +1.2, +2.0, +1.4, and +2.0 respectively under the similar FLOPs setting. By further pretraining on the larger dataset ImageNet-21K, we achieve 87.5% Top-1 accuracy on ImageNet-1K and high segmentation performance on ADE20K with 55.7 mIoU. The code and models are available at https://github.com/microsoft/CSWin-Transformer.

Detecting out-of-distribution (OOD) samples in medical imaging plays an important role for downstream medical diagnosis. However, existing OOD detectors are demonstrated on natural images composed of inter-classes and have difficulty generalizing to medical images. The key issue is the granularity of OOD data in the medical domain, where intra-class OOD samples are predominant. We focus on the generalizability of OOD detection for medical images and propose a self-supervised Cascade Variational autoencoder-based Anomaly Detector (CVAD). We use a variational autoencoders' cascade architecture, which combines latent representation at multiple scales, before being fed to a discriminator to distinguish the OOD data from the in-distribution (ID) data. Finally, both the reconstruction error and the OOD probability predicted by the binary discriminator are used to determine the anomalies. We compare the performance with the state-of-the-art deep learning models to demonstrate our model's efficacy on various open-access medical imaging datasets for both intra- and inter-class OOD. Further extensive results on datasets including common natural datasets show our model's effectiveness and generalizability. The code is available at https://github.com/XiaoyuanGuo/CVAD.

Cervical disc herniation (CDH) is a prevalent musculoskeletal disorder that significantly impacts health and requires labor-intensive analysis from experts. Despite advancements in automated detection of medical imaging, two significant challenges hinder the real-world application of these methods. First, the computational complexity and resource demands present a significant gap for real-time application. Second, noise in MRI reduces the effectiveness of existing methods by distorting feature extraction. To address these challenges, we propose three key contributions: Firstly, we introduced MedDet, which leverages the multi-teacher single-student knowledge distillation for model compression and efficiency, meanwhile integrating generative adversarial training to enhance performance. Additionally, we customize the second-order nmODE to improve the model's resistance to noise in MRI. Lastly, we conducted comprehensive experiments on the CDH-1848 dataset, achieving up to a 5% improvement in mAP compared to previous methods. Our approach also delivers over 5 times faster inference speed, with approximately 67.8% reduction in parameters and 36.9% reduction in FLOPs compared to the teacher model. These advancements significantly enhance the performance and efficiency of automated CDH detection, demonstrating promising potential for future application in clinical practice. See project website https://steve-zeyu-zhang.github.io/MedDet

Latent factor models are the driving forces of the state-of-the-art recommender systems, with an important insight of vectorizing raw input features into dense embeddings. The dimensions of different feature embeddings are often set to a same value empirically, which limits the predictive performance of latent factor models. Existing works have proposed heuristic or reinforcement learning-based methods to search for mixed feature embedding dimensions. For efficiency concern, these methods typically choose embedding dimensions from a restricted set of candidate dimensions. However, this restriction will hurt the flexibility of dimension selection, leading to suboptimal performance of search results. In this paper, we propose Differentiable Neural Input Search (DNIS), a method that searches for mixed feature embedding dimensions in a more flexible space through continuous relaxation and differentiable optimization. The key idea is to introduce a soft selection layer that controls the significance of each embedding dimension, and optimize this layer according to model's validation performance. DNIS is model-agnostic and thus can be seamlessly incorporated with existing latent factor models for recommendation. We conduct experiments with various architectures of latent factor models on three public real-world datasets for rating prediction, Click-Through-Rate (CTR) prediction, and top-k item recommendation. The results demonstrate that our method achieves the best predictive performance compared with existing neural input search approaches with fewer embedding parameters and less time cost.

The distributed representation of symbols is one of the key technologies in machine learning systems today, playing a pivotal role in modern natural language processing. Traditional word embeddings associate a separate vector with each word. While this approach is simple and leads to good performance, it requires a lot of memory for representing a large vocabulary. To reduce the memory footprint, the default embedding layer in spaCy is a hash embeddings layer. It is a stochastic approximation of traditional embeddings that provides unique vectors for a large number of words without explicitly storing a separate vector for each of them. To be able to compute meaningful representations for both known and unknown words, hash embeddings represent each word as a summary of the normalized word form, subword information and word shape. Together, these features produce a multi-embedding of a word. In this technical report we lay out a bit of history and introduce the embedding methods in spaCy in detail. Second, we critically evaluate the hash embedding architecture with multi-embeddings on Named Entity Recognition datasets from a variety of domains and languages. The experiments validate most key design choices behind spaCy's embedders, but we also uncover a few surprising results.

As with many machine learning problems, the progress of image generation methods hinges on good evaluation metrics. One of the most popular is the Frechet Inception Distance (FID). FID estimates the distance between a distribution of Inception-v3 features of real images, and those of images generated by the algorithm. We highlight important drawbacks of FID: Inception's poor representation of the rich and varied content generated by modern text-to-image models, incorrect normality assumptions, and poor sample complexity. We call for a reevaluation of FID's use as the primary quality metric for generated images. We empirically demonstrate that FID contradicts human raters, it does not reflect gradual improvement of iterative text-to-image models, it does not capture distortion levels, and that it produces inconsistent results when varying the sample size. We also propose an alternative new metric, CMMD, based on richer CLIP embeddings and the maximum mean discrepancy distance with the Gaussian RBF kernel. It is an unbiased estimator that does not make any assumptions on the probability distribution of the embeddings and is sample efficient. Through extensive experiments and analysis, we demonstrate that FID-based evaluations of text-to-image models may be unreliable, and that CMMD offers a more robust and reliable assessment of image quality.

Longitudinal analysis has great potential to reveal developmental trajectories and monitor disease progression in medical imaging. This process relies on consistent and robust joint 4D segmentation. Traditional techniques are dependent on the similarity of images over time and the use of subject-specific priors to reduce random variation and improve the robustness and sensitivity of the overall longitudinal analysis. This is however slow and computationally intensive as subject-specific templates need to be rebuilt every time. The focus of this work to accelerate this analysis with the use of deep learning. The proposed approach is based on deep CNNs and incorporates semantic segmentation and provides a longitudinal relationship for the same subject. The proposed approach is based on deep CNNs and incorporates semantic segmentation and provides a longitudinal relationship for the same subject. The state of art using 3D patches as inputs to modified Unet provides results around {0.91 pm 0.5} Dice and using multi-view atlas in CNNs provide around the same results. In this work, different models are explored, each offers better accuracy and fast results while increasing the segmentation quality. These methods are evaluated on 135 scans from the EADC-ADNI Harmonized Hippocampus Protocol. Proposed CNN based segmentation approaches demonstrate how 2D segmentation using prior slices can provide similar results to 3D segmentation while maintaining good continuity in the 3D dimension and improved speed. Just using 2D modified sagittal slices provide us a better Dice and longitudinal analysis for a given subject. For the ADNI dataset, using the simple UNet CNN technique gives us {0.84 pm 0.5} and while using modified CNN techniques on the same input yields {0.89 pm 0.5}. Rate of atrophy and RMS error are calculated for several test cases using various methods and analyzed.

The autoencoder is an unsupervised learning paradigm that aims to create a compact latent representation of data by minimizing the reconstruction loss. However, it tends to overlook the fact that most data (images) are embedded in a lower-dimensional space, which is crucial for effective data representation. To address this limitation, we propose a novel approach called Low-Rank Autoencoder (LoRAE). In LoRAE, we incorporated a low-rank regularizer to adaptively reconstruct a low-dimensional latent space while preserving the basic objective of an autoencoder. This helps embed the data in a lower-dimensional space while preserving important information. It is a simple autoencoder extension that learns low-rank latent space. Theoretically, we establish a tighter error bound for our model. Empirically, our model's superiority shines through various tasks such as image generation and downstream classification. Both theoretical and practical outcomes highlight the importance of acquiring low-dimensional embeddings.

Causal representation learning seeks to extract high-level latent factors from low-level sensory data. Most existing methods rely on observational data and structural assumptions (e.g., conditional independence) to identify the latent factors. However, interventional data is prevalent across applications. Can interventional data facilitate causal representation learning? We explore this question in this paper. The key observation is that interventional data often carries geometric signatures of the latent factors' support (i.e. what values each latent can possibly take). For example, when the latent factors are causally connected, interventions can break the dependency between the intervened latents' support and their ancestors'. Leveraging this fact, we prove that the latent causal factors can be identified up to permutation and scaling given data from perfect do interventions. Moreover, we can achieve block affine identification, namely the estimated latent factors are only entangled with a few other latents if we have access to data from imperfect interventions. These results highlight the unique power of interventional data in causal representation learning; they can enable provable identification of latent factors without any assumptions about their distributions or dependency structure.

Following the success of Word2Vec embeddings, graph embeddings (GEs) have gained substantial traction. GEs are commonly generated and evaluated extrinsically on downstream applications, but intrinsic evaluations of the original graph properties in terms of topological structure and semantic information have been lacking. Understanding these will help identify the deficiency of the various families of GE methods when vectorizing graphs in terms of preserving the relevant knowledge or learning incorrect knowledge. To address this, we propose RESTORE, a framework for intrinsic GEs assessment through graph reconstruction. We show that reconstructing the original graph from the underlying GEs yields insights into the relative amount of information preserved in a given vector form. We first introduce the graph reconstruction task. We generate GEs from three GE families based on factorization methods, random walks, and deep learning (with representative algorithms from each family) on the CommonSense Knowledge Graph (CSKG). We analyze their effectiveness in preserving the (a) topological structure of node-level graph reconstruction with an increasing number of hops and (b) semantic information on various word semantic and analogy tests. Our evaluations show deep learning-based GE algorithm (SDNE) is overall better at preserving (a) with a mean average precision (mAP) of 0.54 and 0.35 for 2 and 3-hop reconstruction respectively, while the factorization-based algorithm (HOPE) is better at encapsulating (b) with an average Euclidean distance of 0.14, 0.17, and 0.11 for 1, 2, and 3-hop reconstruction respectively. The modest performance of these GEs leaves room for further research avenues on better graph representation learning.

Modern studies in radiograph representation learning rely on either self-supervision to encode invariant semantics or associated radiology reports to incorporate medical expertise, while the complementarity between them is barely noticed. To explore this, we formulate the self- and report-completion as two complementary objectives and present a unified framework based on masked record modeling (MRM). In practice, MRM reconstructs masked image patches and masked report tokens following a multi-task scheme to learn knowledge-enhanced semantic representations. With MRM pre-training, we obtain pre-trained models that can be well transferred to various radiography tasks. Specifically, we find that MRM offers superior performance in label-efficient fine-tuning. For instance, MRM achieves 88.5% mean AUC on CheXpert using 1% labeled data, outperforming previous R^2L methods with 100% labels. On NIH ChestX-ray, MRM outperforms the best performing counterpart by about 3% under small labeling ratios. Besides, MRM surpasses self- and report-supervised pre-training in identifying the pneumonia type and the pneumothorax area, sometimes by large margins.

While most network embedding techniques model the relative positions of nodes in a network, recently there has been significant interest in structural embeddings that model node role equivalences, irrespective of their distances to any specific nodes. We present PhUSION, a proximity-based unified framework for computing structural and positional node embeddings, which leverages well-established methods for calculating node proximity scores. Clarifying a point of contention in the literature, we show which step of PhUSION produces the different kinds of embeddings and what steps can be used by both. Moreover, by aggregating the PhUSION node embeddings, we obtain graph-level features that model information lost by previous graph feature learning and kernel methods. In a comprehensive empirical study with over 10 datasets, 4 tasks, and 35 methods, we systematically reveal successful design choices for node and graph-level machine learning with embeddings.

2D-to-3D human pose lifting is fundamental for 3D human pose estimation (HPE), for which graph convolutional networks (GCNs) have proven inherently suitable for modeling the human skeletal topology. However, the current GCN-based 3D HPE methods update the node features by aggregating their neighbors' information without considering the interaction of joints in different joint synergies. Although some studies have proposed importing limb information to learn the movement patterns, the latent synergies among joints, such as maintaining balance are seldom investigated. We propose the Hop-wise GraphFormer with Intragroup Joint Refinement (HopFIR) architecture to tackle the 3D HPE problem. HopFIR mainly consists of a novel hop-wise GraphFormer (HGF) module and an intragroup joint refinement (IJR) module. The HGF module groups the joints by k-hop neighbors and applies a hopwise transformer-like attention mechanism to these groups to discover latent joint synergies. The IJR module leverages the prior limb information for peripheral joint refinement. Extensive experimental results show that HopFIR outperforms the SOTA methods by a large margin, with a mean per-joint position error (MPJPE) on the Human3.6M dataset of 32.67 mm. We also demonstrate that the state-of-the-art GCN-based methods can benefit from the proposed hop-wise attention mechanism with a significant improvement in performance: SemGCN and MGCN are improved by 8.9% and 4.5%, respectively.

Randomized controlled trials (RCTs) are considered the gold standard for estimating the average treatment effect (ATE) of interventions. One use of RCTs is to study the causes of global poverty -- a subject explicitly cited in the 2019 Nobel Memorial Prize awarded to Duflo, Banerjee, and Kremer "for their experimental approach to alleviating global poverty." Because the ATE is a population summary, anti-poverty experiments often seek to unpack the effect variation around the ATE by conditioning (CATE) on tabular variables such as age and ethnicity that were measured during the RCT data collection. Although such variables are key to unpacking CATE, using only such variables may fail to capture historical, geographical, or neighborhood-specific contributors to effect variation, as tabular RCT data are often only observed near the time of the experiment. In global poverty research, when the location of the experiment units is approximately known, satellite imagery can provide a window into such factors important for understanding heterogeneity. However, there is no method that specifically enables applied researchers to analyze CATE from images. In this paper, using a deep probabilistic modeling framework, we develop such a method that estimates latent clusters of images by identifying images with similar treatment effects distributions. Our interpretable image CATE model also includes a sensitivity factor that quantifies the importance of image segments contributing to the effect cluster prediction. We compare the proposed methods against alternatives in simulation; also, we show how the model works in an actual RCT, estimating the effects of an anti-poverty intervention in northern Uganda and obtaining a posterior predictive distribution over effects for the rest of the country where no experimental data was collected. We make all models available in open-source software.

Recent image generation schemes typically capture image distribution in a pre-constructed latent space relying on a frozen image tokenizer. Though the performance of tokenizer plays an essential role to the successful generation, its current evaluation metrics (e.g. rFID) fail to precisely assess the tokenizer and correlate its performance to the generation quality (e.g. gFID). In this paper, we comprehensively analyze the reason for the discrepancy of reconstruction and generation qualities in a discrete latent space, and, from which, we propose a novel plug-and-play tokenizer training scheme to facilitate latent space construction. Specifically, a latent perturbation approach is proposed to simulate sampling noises, i.e., the unexpected tokens sampled, from the generative process. With the latent perturbation, we further propose (1) a novel tokenizer evaluation metric, i.e., pFID, which successfully correlates the tokenizer performance to generation quality and (2) a plug-and-play tokenizer training scheme, which significantly enhances the robustness of tokenizer thus boosting the generation quality and convergence speed. Extensive benchmarking are conducted with 11 advanced discrete image tokenizers with 2 autoregressive generation models to validate our approach. The tokenizer trained with our proposed latent perturbation achieve a notable 1.60 gFID with classifier-free guidance (CFG) and 3.45 gFID without CFG with a sim400M generator. Code: https://github.com/lxa9867/ImageFolder.

Topic models have been prevalent for decades with various applications. However, existing topic models commonly suffer from the notorious topic collapsing: discovered topics semantically collapse towards each other, leading to highly repetitive topics, insufficient topic discovery, and damaged model interpretability. In this paper, we propose a new neural topic model, Embedding Clustering Regularization Topic Model (ECRTM). Besides the existing reconstruction error, we propose a novel Embedding Clustering Regularization (ECR), which forces each topic embedding to be the center of a separately aggregated word embedding cluster in the semantic space. This enables each produced topic to contain distinct word semantics, which alleviates topic collapsing. Regularized by ECR, our ECRTM generates diverse and coherent topics together with high-quality topic distributions of documents. Extensive experiments on benchmark datasets demonstrate that ECRTM effectively addresses the topic collapsing issue and consistently surpasses state-of-the-art baselines in terms of topic quality, topic distributions of documents, and downstream classification tasks.

Self-supervision is often used for pre-training to foster performance on a downstream task by constructing meaningful representations of samples. Self-supervised learning (SSL) generally involves generating different views of the same sample and thus requires data augmentations that are challenging to construct for tabular data. This constitutes one of the main challenges of self-supervision for structured data. In the present work, we propose a novel augmentation-free SSL method for tabular data. Our approach, T-JEPA, relies on a Joint Embedding Predictive Architecture (JEPA) and is akin to mask reconstruction in the latent space. It involves predicting the latent representation of one subset of features from the latent representation of a different subset within the same sample, thereby learning rich representations without augmentations. We use our method as a pre-training technique and train several deep classifiers on the obtained representation. Our experimental results demonstrate a substantial improvement in both classification and regression tasks, outperforming models trained directly on samples in their original data space. Moreover, T-JEPA enables some methods to consistently outperform or match the performance of traditional methods likes Gradient Boosted Decision Trees. To understand why, we extensively characterize the obtained representations and show that T-JEPA effectively identifies relevant features for downstream tasks without access to the labels. Additionally, we introduce regularization tokens, a novel regularization method critical for training of JEPA-based models on structured data.

Our approach, which we call Embeddings for Language/Image-aligned X-Rays, or ELIXR, leverages a language-aligned image encoder combined or grafted onto a fixed LLM, PaLM 2, to perform a broad range of tasks. We train this lightweight adapter architecture using images paired with corresponding free-text radiology reports from the MIMIC-CXR dataset. ELIXR achieved state-of-the-art performance on zero-shot chest X-ray (CXR) classification (mean AUC of 0.850 across 13 findings), data-efficient CXR classification (mean AUCs of 0.893 and 0.898 across five findings (atelectasis, cardiomegaly, consolidation, pleural effusion, and pulmonary edema) for 1% (~2,200 images) and 10% (~22,000 images) training data), and semantic search (0.76 normalized discounted cumulative gain (NDCG) across nineteen queries, including perfect retrieval on twelve of them). Compared to existing data-efficient methods including supervised contrastive learning (SupCon), ELIXR required two orders of magnitude less data to reach similar performance. ELIXR also showed promise on CXR vision-language tasks, demonstrating overall accuracies of 58.7% and 62.5% on visual question answering and report quality assurance tasks, respectively. These results suggest that ELIXR is a robust and versatile approach to CXR AI.

Parameter-efficient fine-tuning methods, represented by LoRA, play an essential role in adapting large-scale pre-trained models to downstream tasks. However, fine-tuning LoRA-series models also faces the risk of overfitting on the training dataset, and yet there's still a lack of theoretical guidance and practical mechanism to control overfitting on LoRA-based PEFT methods. In this paper, we propose a LoRA Dropout mechanism for the LoRA-based methods by introducing random noises to the learnable low-rank matrices and increasing parameter sparsity. We then demonstrate the theoretical mechanism of our LoRA Dropout mechanism from the perspective of sparsity regularization by providing a generalization error bound under this framework. Theoretical results show that appropriate sparsity would help tighten the gap between empirical and generalization risks and thereby control overfitting. Furthermore, based on the LoRA Dropout framework, we introduce a test-time ensemble strategy and provide theoretical evidence demonstrating that the ensemble method can further compress the error bound, and lead to better performance during inference time. Extensive experiments on various NLP tasks provide practical validations of the effectiveness of our LoRA Dropout framework in improving model accuracy and calibration.

Visual Language Models (VLMs) have demonstrated impressive capabilities in visual grounding tasks. However, their effectiveness in the medical domain, particularly for abnormality detection and localization within medical images, remains underexplored. A major challenge is the complex and abstract nature of medical terminology, which makes it difficult to directly associate pathological anomaly terms with their corresponding visual features. In this work, we introduce a novel approach to enhance VLM performance in medical abnormality detection and localization by leveraging decomposed medical knowledge. Instead of directly prompting models to recognize specific abnormalities, we focus on breaking down medical concepts into fundamental attributes and common visual patterns. This strategy promotes a stronger alignment between textual descriptions and visual features, improving both the recognition and localization of abnormalities in medical images.We evaluate our method on the 0.23B Florence-2 base model and demonstrate that it achieves comparable performance in abnormality grounding to significantly larger 7B LLaVA-based medical VLMs, despite being trained on only 1.5% of the data used for such models. Experimental results also demonstrate the effectiveness of our approach in both known and previously unseen abnormalities, suggesting its strong generalization capabilities.

Masked image modelling (MIM) is a powerful self-supervised representation learning paradigm, whose potential has not been widely demonstrated in medical image analysis. In this work, we show the capacity of MIM to capture rich semantic representations of Haemotoxylin & Eosin (H&E)-stained images at the nuclear level. Inspired by Bidirectional Encoder representation from Image Transformers (BEiT), we split the images into smaller patches and generate corresponding discrete visual tokens. In addition to the regular grid-based patches, typically used in visual Transformers, we introduce patches of individual cell nuclei. We propose positional encoding of the irregular distribution of these structures within an image. We pre-train the model in a self-supervised manner on H&E-stained whole-slide images of diffuse large B-cell lymphoma, where cell nuclei have been segmented. The pre-training objective is to recover the original discrete visual tokens of the masked image on the one hand, and to reconstruct the visual tokens of the masked object instances on the other. Coupling these two pre-training tasks allows us to build powerful, context-aware representations of nuclei. Our model generalizes well and can be fine-tuned on downstream classification tasks, achieving improved cell classification accuracy on PanNuke dataset by more than 5% compared to current instance segmentation methods.

We introduce a self-supervised vision representation model BEiT, which stands for Bidirectional Encoder representation from Image Transformers. Following BERT developed in the natural language processing area, we propose a masked image modeling task to pretrain vision Transformers. Specifically, each image has two views in our pre-training, i.e, image patches (such as 16x16 pixels), and visual tokens (i.e., discrete tokens). We first "tokenize" the original image into visual tokens. Then we randomly mask some image patches and fed them into the backbone Transformer. The pre-training objective is to recover the original visual tokens based on the corrupted image patches. After pre-training BEiT, we directly fine-tune the model parameters on downstream tasks by appending task layers upon the pretrained encoder. Experimental results on image classification and semantic segmentation show that our model achieves competitive results with previous pre-training methods. For example, base-size BEiT achieves 83.2% top-1 accuracy on ImageNet-1K, significantly outperforming from-scratch DeiT training (81.8%) with the same setup. Moreover, large-size BEiT obtains 86.3% only using ImageNet-1K, even outperforming ViT-L with supervised pre-training on ImageNet-22K (85.2%). The code and pretrained models are available at https://aka.ms/beit.

Generative Models (GMs) have attracted considerable attention due to their tremendous success in various domains, such as computer vision where they are capable to generate impressive realistic-looking images. Likelihood-based GMs are attractive due to the possibility to generate new data by a single model evaluation. However, they typically achieve lower sample quality compared to state-of-the-art score-based diffusion models (DMs). This paper provides a significant step in the direction of addressing this limitation. The idea is to borrow one of the strengths of score-based DMs, which is the ability to perform accurate density estimation in low-density regions and to address manifold overfitting by means of data mollification. We connect data mollification through the addition of Gaussian noise to Gaussian homotopy, which is a well-known technique to improve optimization. Data mollification can be implemented by adding one line of code in the optimization loop, and we demonstrate that this provides a boost in generation quality of likelihood-based GMs, without computational overheads. We report results on image data sets with popular likelihood-based GMs, including variants of variational autoencoders and normalizing flows, showing large improvements in FID score.

Foreground-conditioned inpainting aims to seamlessly fill the background region of an image by utilizing the provided foreground subject and a text description. While existing T2I-based image inpainting methods can be applied to this task, they suffer from issues of subject shape expansion, distortion, or impaired ability to align with the text description, resulting in inconsistencies between the visual elements and the text description. To address these challenges, we propose Pinco, a plug-and-play foreground-conditioned inpainting adapter that generates high-quality backgrounds with good text alignment while effectively preserving the shape of the foreground subject. Firstly, we design a Self-Consistent Adapter that integrates the foreground subject features into the layout-related self-attention layer, which helps to alleviate conflicts between the text and subject features by ensuring that the model can effectively consider the foreground subject's characteristics while processing the overall image layout. Secondly, we design a Decoupled Image Feature Extraction method that employs distinct architectures to extract semantic and shape features separately, significantly improving subject feature extraction and ensuring high-quality preservation of the subject's shape. Thirdly, to ensure precise utilization of the extracted features and to focus attention on the subject region, we introduce a Shared Positional Embedding Anchor, greatly improving the model's understanding of subject features and boosting training efficiency. Extensive experiments demonstrate that our method achieves superior performance and efficiency in foreground-conditioned inpainting.

Masked Image Modeling (MIM) is a new self-supervised vision pre-training paradigm using Vision Transformer (ViT). Previous works can be pixel-based or token-based, using original pixels or discrete visual tokens from parametric tokenizer models, respectively. Our proposed approach, CCViT, leverages k-means clustering to obtain centroids for image modeling without supervised training of tokenizer model. The centroids represent patch pixels and index tokens and have the property of local invariance. Non-parametric centroid tokenizer only takes seconds to create and is faster for token inference. Specifically, we adopt patch masking and centroid replacement strategies to construct corrupted inputs, and two stacked encoder blocks to predict corrupted patch tokens and reconstruct original patch pixels. Experiments show that the ViT-B model with only 300 epochs achieves 84.3\% top-1 accuracy on ImageNet-1K classification and 51.6\% on ADE20K semantic segmentation. Our approach achieves competitive results with BEiTv2 without distillation training from other models and outperforms other methods such as MAE.

Recent studies indicate that the denoising process in deep generative diffusion models implicitly learns and memorizes semantic information from the data distribution. These findings suggest that capturing more complex data distributions requires larger neural networks, leading to a substantial increase in computational demands, which in turn become the primary bottleneck in both training and inference of diffusion models. To this end, we introduce Generative Modeling with Explicit Memory (GMem), leveraging an external memory bank in both training and sampling phases of diffusion models. This approach preserves semantic information from data distributions, reducing reliance on neural network capacity for learning and generalizing across diverse datasets. The results are significant: our GMem enhances both training, sampling efficiency, and generation quality. For instance, on ImageNet at 256 times 256 resolution, GMem accelerates SiT training by over 46.7times, achieving the performance of a SiT model trained for 7M steps in fewer than 150K steps. Compared to the most efficient existing method, REPA, GMem still offers a 16times speedup, attaining an FID score of 5.75 within 250K steps, whereas REPA requires over 4M steps. Additionally, our method achieves state-of-the-art generation quality, with an FID score of {3.56} without classifier-free guidance on ImageNet 256times256. Our code is available at https://github.com/LINs-lab/GMem.

This paper presents a new exploration into a category of diffusion models built upon state space architecture. We endeavor to train diffusion models for image data, wherein the traditional U-Net backbone is supplanted by a state space backbone, functioning on raw patches or latent space. Given its notable efficacy in accommodating long-range dependencies, Diffusion State Space Models (DiS) are distinguished by treating all inputs including time, condition, and noisy image patches as tokens. Our assessment of DiS encompasses both unconditional and class-conditional image generation scenarios, revealing that DiS exhibits comparable, if not superior, performance to CNN-based or Transformer-based U-Net architectures of commensurate size. Furthermore, we analyze the scalability of DiS, gauged by the forward pass complexity quantified in Gflops. DiS models with higher Gflops, achieved through augmentation of depth/width or augmentation of input tokens, consistently demonstrate lower FID. In addition to demonstrating commendable scalability characteristics, DiS-H/2 models in latent space achieve performance levels akin to prior diffusion models on class-conditional ImageNet benchmarks at the resolution of 256times256 and 512times512, while significantly reducing the computational burden. The code and models are available at: https://github.com/feizc/DiS.

Despite the recent advances in personalized text-to-image (P-T2I) generative models, subject-driven T2I remains challenging. The primary bottlenecks include 1) Intensive training resource requirements, 2) Hyper-parameter sensitivity leading to inconsistent outputs, and 3) Balancing the intricacies of novel visual concept and composition alignment. We start by re-iterating the core philosophy of T2I diffusion models to address the above limitations. Predominantly, contemporary subject-driven T2I approaches hinge on Latent Diffusion Models (LDMs), which facilitate T2I mapping through cross-attention layers. While LDMs offer distinct advantages, P-T2I methods' reliance on the latent space of these diffusion models significantly escalates resource demands, leading to inconsistent results and necessitating numerous iterations for a single desired image. Recently, ECLIPSE has demonstrated a more resource-efficient pathway for training UnCLIP-based T2I models, circumventing the need for diffusion text-to-image priors. Building on this, we introduce lambda-ECLIPSE. Our method illustrates that effective P-T2I does not necessarily depend on the latent space of diffusion models. lambda-ECLIPSE achieves single, multi-subject, and edge-guided T2I personalization with just 34M parameters and is trained on a mere 74 GPU hours using 1.6M image-text interleaved data. Through extensive experiments, we also establish that lambda-ECLIPSE surpasses existing baselines in composition alignment while preserving concept alignment performance, even with significantly lower resource utilization.

Vision Transformer (ViT) has emerged as a powerful architecture in the realm of modern computer vision. However, its application in certain imaging fields, such as microscopy and satellite imaging, presents unique challenges. In these domains, images often contain multiple channels, each carrying semantically distinct and independent information. Furthermore, the model must demonstrate robustness to sparsity in input channels, as they may not be densely available during training or testing. In this paper, we propose a modification to the ViT architecture that enhances reasoning across the input channels and introduce Hierarchical Channel Sampling (HCS) as an additional regularization technique to ensure robustness when only partial channels are presented during test time. Our proposed model, ChannelViT, constructs patch tokens independently from each input channel and utilizes a learnable channel embedding that is added to the patch tokens, similar to positional embeddings. We evaluate the performance of ChannelViT on ImageNet, JUMP-CP (microscopy cell imaging), and So2Sat (satellite imaging). Our results show that ChannelViT outperforms ViT on classification tasks and generalizes well, even when a subset of input channels is used during testing. Across our experiments, HCS proves to be a powerful regularizer, independent of the architecture employed, suggesting itself as a straightforward technique for robust ViT training. Lastly, we find that ChannelViT generalizes effectively even when there is limited access to all channels during training, highlighting its potential for multi-channel imaging under real-world conditions with sparse sensors. Our code is available at https://github.com/insitro/ChannelViT.

Advanced diffusion-based Text-to-Image (T2I) models, such as the Stable Diffusion Model, have made significant progress in generating diverse and high-quality images using text prompts alone. However, T2I models are unable to accurately map identities (IDs) when non-famous users require personalized image generation. The main problem is that existing T2I models do not learn the ID-image alignments of new users. The previous methods either failed to accurately fit the face region or lost the interactive generative ability with other existing concepts in T2I models (i.e., unable to generate other concepts described in given prompts such as scenes, actions, and facial attributes). In this paper, we focus on accurate and semantic-fidelity ID embedding into the Stable Diffusion Model for personalized generation. We address this challenge from two perspectives: face-wise region fitting, and semantic-fidelity token optimization. Specifically, we first visualize the attention overfit problem, and propose a face-wise attention loss to fit the face region instead of the whole target image. This key trick significantly enhances the ID accuracy and interactive generative ability with other existing concepts. Then, we optimize one ID representation as multiple per-stage tokens where each token contains two disentangled features. This expansion of the textual conditioning space enhances semantic-fidelity control. Extensive experiments validate that our results exhibit superior ID accuracy and manipulation ability compared to previous methods.

Efficient, reliable and reproducible target volume delineation is a key step in the effective planning of breast radiotherapy. However, post-operative breast target delineation is challenging as the contrast between the tumor bed volume (TBV) and normal breast tissue is relatively low in CT images. In this study, we propose to mimic the marker-guidance procedure in manual target delineation. We developed a saliency-based deep learning segmentation (SDL-Seg) algorithm for accurate TBV segmentation in post-operative breast irradiation. The SDL-Seg algorithm incorporates saliency information in the form of markers' location cues into a U-Net model. The design forces the model to encode the location-related features, which underscores regions with high saliency levels and suppresses low saliency regions. The saliency maps were generated by identifying markers on CT images. Markers' locations were then converted to probability maps using a distance-transformation coupled with a Gaussian filter. Subsequently, the CT images and the corresponding saliency maps formed a multi-channel input for the SDL-Seg network. Our in-house dataset was comprised of 145 prone CT images from 29 post-operative breast cancer patients, who received 5-fraction partial breast irradiation (PBI) regimen on GammaPod. The performance of the proposed method was compared against basic U-Net. Our model achieved mean (standard deviation) of 76.4 %, 6.76 mm, and 1.9 mm for DSC, HD95, and ASD respectively on the test set with computation time of below 11 seconds per one CT volume. SDL-Seg showed superior performance relative to basic U-Net for all the evaluation metrics while preserving low computation cost. The findings demonstrate that SDL-Seg is a promising approach for improving the efficiency and accuracy of the on-line treatment planning procedure of PBI, such as GammaPod based PBI.

We propose Equiangular Basis Vectors (EBVs) for classification tasks. In deep neural networks, models usually end with a k-way fully connected layer with softmax to handle different classification tasks. The learning objective of these methods can be summarized as mapping the learned feature representations to the samples' label space. While in metric learning approaches, the main objective is to learn a transformation function that maps training data points from the original space to a new space where similar points are closer while dissimilar points become farther apart. Different from previous methods, our EBVs generate normalized vector embeddings as "predefined classifiers" which are required to not only be with the equal status between each other, but also be as orthogonal as possible. By minimizing the spherical distance of the embedding of an input between its categorical EBV in training, the predictions can be obtained by identifying the categorical EBV with the smallest distance during inference. Various experiments on the ImageNet-1K dataset and other downstream tasks demonstrate that our method outperforms the general fully connected classifier while it does not introduce huge additional computation compared with classical metric learning methods. Our EBVs won the first place in the 2022 DIGIX Global AI Challenge, and our code is open-source and available at https://github.com/NJUST-VIPGroup/Equiangular-Basis-Vectors.

Vision-language pre-training for chest X-rays has made significant strides, primarily by utilizing paired radiographs and radiology reports. However, existing approaches often face challenges in encoding medical knowledge effectively. While radiology reports provide insights into the current disease manifestation, medical definitions (as used by contemporary methods) tend to be overly abstract, creating a gap in knowledge. To address this, we propose DeViDe, a novel transformer-based method that leverages radiographic descriptions from the open web. These descriptions outline general visual characteristics of diseases in radiographs, and when combined with abstract definitions and radiology reports, provide a holistic snapshot of knowledge. DeViDe incorporates three key features for knowledge-augmented vision language alignment: First, a large-language model-based augmentation is employed to homogenise medical knowledge from diverse sources. Second, this knowledge is aligned with image information at various levels of granularity. Third, a novel projection layer is proposed to handle the complexity of aligning each image with multiple descriptions arising in a multi-label setting. In zero-shot settings, DeViDe performs comparably to fully supervised models on external datasets and achieves state-of-the-art results on three large-scale datasets. Additionally, fine-tuning DeViDe on four downstream tasks and six segmentation tasks showcases its superior performance across data from diverse distributions.

In this paper we present Mask DINO, a unified object detection and segmentation framework. Mask DINO extends DINO (DETR with Improved Denoising Anchor Boxes) by adding a mask prediction branch which supports all image segmentation tasks (instance, panoptic, and semantic). It makes use of the query embeddings from DINO to dot-product a high-resolution pixel embedding map to predict a set of binary masks. Some key components in DINO are extended for segmentation through a shared architecture and training process. Mask DINO is simple, efficient, and scalable, and it can benefit from joint large-scale detection and segmentation datasets. Our experiments show that Mask DINO significantly outperforms all existing specialized segmentation methods, both on a ResNet-50 backbone and a pre-trained model with SwinL backbone. Notably, Mask DINO establishes the best results to date on instance segmentation (54.5 AP on COCO), panoptic segmentation (59.4 PQ on COCO), and semantic segmentation (60.8 mIoU on ADE20K) among models under one billion parameters. Code is available at https://github.com/IDEACVR/MaskDINO.

Tracking biosignals is crucial for monitoring wellness and preempting the development of severe medical conditions. Today, wearable devices can conveniently record various biosignals, creating the opportunity to monitor health status without disruption to one's daily routine. Despite widespread use of wearable devices and existing digital biomarkers, the absence of curated data with annotated medical labels hinders the development of new biomarkers to measure common health conditions. In fact, medical datasets are usually small in comparison to other domains, which is an obstacle for developing neural network models for biosignals. To address this challenge, we have employed self-supervised learning using the unlabeled sensor data collected under informed consent from the large longitudinal Apple Heart and Movement Study (AHMS) to train foundation models for two common biosignals: photoplethysmography (PPG) and electrocardiogram (ECG) recorded on Apple Watch. We curated PPG and ECG datasets from AHMS that include data from ~141K participants spanning ~3 years. Our self-supervised learning framework includes participant level positive pair selection, stochastic augmentation module and a regularized contrastive loss optimized with momentum training, and generalizes well to both PPG and ECG modalities. We show that the pre-trained foundation models readily encode information regarding participants' demographics and health conditions. To the best of our knowledge, this is the first study that builds foundation models using large-scale PPG and ECG data collected via wearable consumer devices x2013 prior works have commonly used smaller-size datasets collected in clinical and experimental settings. We believe PPG and ECG foundation models can enhance future wearable devices by reducing the reliance on labeled data and hold the potential to help the users improve their health.

Learning embedding table plays a fundamental role in Click-through rate(CTR) prediction from the view of the model performance and memory usage. The embedding table is a two-dimensional tensor, with its axes indicating the number of feature values and the embedding dimension, respectively. To learn an efficient and effective embedding table, recent works either assign various embedding dimensions for feature fields and reduce the number of embeddings respectively or mask the embedding table parameters. However, all these existing works cannot get an optimal embedding table. On the one hand, various embedding dimensions still require a large amount of memory due to the vast number of features in the dataset. On the other hand, decreasing the number of embeddings usually suffers from performance degradation, which is intolerable in CTR prediction. Finally, pruning embedding parameters will lead to a sparse embedding table, which is hard to be deployed. To this end, we propose an optimal embedding table learning framework OptEmbed, which provides a practical and general method to find an optimal embedding table for various base CTR models. Specifically, we propose pruning the redundant embeddings regarding corresponding features' importance by learnable pruning thresholds. Furthermore, we consider assigning various embedding dimensions as one single candidate architecture. To efficiently search the optimal embedding dimensions, we design a uniform embedding dimension sampling scheme to equally train all candidate architectures, meaning architecture-related parameters and learnable thresholds are trained simultaneously in one supernet. We then propose an evolution search method based on the supernet to find the optimal embedding dimensions for each field. Experiments on public datasets show that OptEmbed can learn a compact embedding table which can further improve the model performance.

Pixel-wise regression is probably the most common problem in fine-grained computer vision tasks, such as estimating keypoint heatmaps and segmentation masks. These regression problems are very challenging particularly because they require, at low computation overheads, modeling long-range dependencies on high-resolution inputs/outputs to estimate the highly nonlinear pixel-wise semantics. While attention mechanisms in Deep Convolutional Neural Networks(DCNNs) has become popular for boosting long-range dependencies, element-specific attention, such as Nonlocal blocks, is highly complex and noise-sensitive to learn, and most of simplified attention hybrids try to reach the best compromise among multiple types of tasks. In this paper, we present the Polarized Self-Attention(PSA) block that incorporates two critical designs towards high-quality pixel-wise regression: (1) Polarized filtering: keeping high internal resolution in both channel and spatial attention computation while completely collapsing input tensors along their counterpart dimensions. (2) Enhancement: composing non-linearity that directly fits the output distribution of typical fine-grained regression, such as the 2D Gaussian distribution (keypoint heatmaps), or the 2D Binormial distribution (binary segmentation masks). PSA appears to have exhausted the representation capacity within its channel-only and spatial-only branches, such that there is only marginal metric differences between its sequential and parallel layouts. Experimental results show that PSA boosts standard baselines by 2-4 points, and boosts state-of-the-arts by 1-2 points on 2D pose estimation and semantic segmentation benchmarks.

Diffusion models have shown tremendous results in image generation. However, due to the iterative nature of the diffusion process and its reliance on classifier-free guidance, inference times are slow. In this paper, we propose a new distillation approach for guided diffusion models in which an external lightweight guide model is trained while the original text-to-image model remains frozen. We show that our method reduces the inference computation of classifier-free guided latent-space diffusion models by almost half, and only requires 1\% trainable parameters of the base model. Furthermore, once trained, our guide model can be applied to various fine-tuned, domain-specific versions of the base diffusion model without the need for additional training: this "plug-and-play" functionality drastically improves inference computation while maintaining the visual fidelity of generated images. Empirically, we show that our approach is able to produce visually appealing results and achieve a comparable FID score to the teacher with as few as 8 to 16 steps.

Weakly supervised semantic segmentation (WSSS) typically utilizes limited semantic annotations to obtain initial Class Activation Maps (CAMs). However, due to the inadequate coupling between class activation responses and semantic information in high-dimensional space, the CAM is prone to object co-occurrence or under-activation, resulting in inferior recognition accuracy. To tackle this issue, we propose DOEI, Dual Optimization of Embedding Information, a novel approach that reconstructs embedding representations through semantic-aware attention weight matrices to optimize the expression capability of embedding information. Specifically, DOEI amplifies tokens with high confidence and suppresses those with low confidence during the class-to-patch interaction. This alignment of activation responses with semantic information strengthens the propagation and decoupling of target features, enabling the generated embeddings to more accurately represent target features in high-level semantic space. In addition, we propose a hybrid-feature alignment module in DOEI that combines RGB values, embedding-guided features, and self-attention weights to increase the reliability of candidate tokens. Comprehensive experiments show that DOEI is an effective plug-and-play module that empowers state-of-the-art visual transformer-based WSSS models to significantly improve the quality of CAMs and segmentation performance on popular benchmarks, including PASCAL VOC (+3.6%, +1.5%, +1.2% mIoU) and MS COCO (+1.2%, +1.6% mIoU). Code will be available at https://github.com/AIGeeksGroup/DOEI.

Diffusion Transformers (DiT) have attracted significant attention in research. However, they suffer from a slow convergence rate. In this paper, we aim to accelerate DiT training without any architectural modification. We identify the following issues in the training process: firstly, certain training strategies do not consistently perform well across different data. Secondly, the effectiveness of supervision at specific timesteps is limited. In response, we propose the following contributions: (1) We introduce a new perspective for interpreting the failure of the strategies. Specifically, we slightly extend the definition of Signal-to-Noise Ratio (SNR) and suggest observing the Probability Density Function (PDF) of SNR to understand the essence of the data robustness of the strategy. (2) We conduct numerous experiments and report over one hundred experimental results to empirically summarize a unified accelerating strategy from the perspective of PDF. (3) We develop a new supervision method that further accelerates the training process of DiT. Based on them, we propose FasterDiT, an exceedingly simple and practicable design strategy. With few lines of code modifications, it achieves 2.30 FID on ImageNet 256 resolution at 1000k iterations, which is comparable to DiT (2.27 FID) but 7 times faster in training.

In this work, we demonstrate that the contextualized word vectors derived from pretrained masked language model-based encoders share a common, perhaps undesirable pattern across layers. Namely, we find cases of persistent outlier neurons within BERT and RoBERTa's hidden state vectors that consistently bear the smallest or largest values in said vectors. In an attempt to investigate the source of this information, we introduce a neuron-level analysis method, which reveals that the outliers are closely related to information captured by positional embeddings. We also pre-train the RoBERTa-base models from scratch and find that the outliers disappear without using positional embeddings. These outliers, we find, are the major cause of anisotropy of encoders' raw vector spaces, and clipping them leads to increased similarity across vectors. We demonstrate this in practice by showing that clipped vectors can more accurately distinguish word senses, as well as lead to better sentence embeddings when mean pooling. In three supervised tasks, we find that clipping does not affect the performance.

Shift equivariance is a fundamental principle that governs how we perceive the world - our recognition of an object remains invariant with respect to shifts. Transformers have gained immense popularity due to their effectiveness in both language and vision tasks. While the self-attention operator in vision transformers (ViT) is permutation-equivariant and thus shift-equivariant, patch embedding, positional encoding, and subsampled attention in ViT variants can disrupt this property, resulting in inconsistent predictions even under small shift perturbations. Although there is a growing trend in incorporating the inductive bias of convolutional neural networks (CNNs) into vision transformers, it does not fully address the issue. We propose an adaptive polyphase anchoring algorithm that can be seamlessly integrated into vision transformer models to ensure shift-equivariance in patch embedding and subsampled attention modules, such as window attention and global subsampled attention. Furthermore, we utilize depth-wise convolution to encode positional information. Our algorithms enable ViT, and its variants such as Twins to achieve 100% consistency with respect to input shift, demonstrate robustness to cropping, flipping, and affine transformations, and maintain consistent predictions even when the original models lose 20 percentage points on average when shifted by just a few pixels with Twins' accuracy dropping from 80.57% to 62.40%.

We present Region-aware Open-vocabulary Vision Transformers (RO-ViT) - a contrastive image-text pretraining recipe to bridge the gap between image-level pretraining and open-vocabulary object detection. At the pretraining phase, we propose to randomly crop and resize regions of positional embeddings instead of using the whole image positional embeddings. This better matches the use of positional embeddings at region-level in the detection finetuning phase. In addition, we replace the common softmax cross entropy loss in contrastive learning with focal loss to better learn the informative yet difficult examples. Finally, we leverage recent advances in novel object proposals to improve open-vocabulary detection finetuning. We evaluate our full model on the LVIS and COCO open-vocabulary detection benchmarks and zero-shot transfer. RO-ViT achieves a state-of-the-art 32.1 AP_r on LVIS, surpassing the best existing approach by +5.8 points in addition to competitive zero-shot transfer detection. Surprisingly, RO-ViT improves the image-level representation as well and achieves the state of the art on 9 out of 12 metrics on COCO and Flickr image-text retrieval benchmarks, outperforming competitive approaches with larger models.

Recent studies have determined that the learned token embeddings of large-scale neural language models are degenerated to be anisotropic with a narrow-cone shape. This phenomenon, called the representation degeneration problem, facilitates an increase in the overall similarity between token embeddings that negatively affect the performance of the models. Although the existing methods that address the degeneration problem based on observations of the phenomenon triggered by the problem improves the performance of the text generation, the training dynamics of token embeddings behind the degeneration problem are still not explored. In this study, we analyze the training dynamics of the token embeddings focusing on rare token embedding. We demonstrate that the specific part of the gradient for rare token embeddings is the key cause of the degeneration problem for all tokens during training stage. Based on the analysis, we propose a novel method called, adaptive gradient gating (AGG). AGG addresses the degeneration problem by gating the specific part of the gradient for rare token embeddings. Experimental results from language modeling, word similarity, and machine translation tasks quantitatively and qualitatively verify the effectiveness of AGG.

We explore different ways to utilize position-based cross-attention in seq2seq networks to enable length generalization in algorithmic tasks. We show that a simple approach of interpolating the original and reversed encoded representations combined with relative attention allows near-perfect length generalization for both forward and reverse lookup tasks or copy tasks that had been generally hard to tackle. We also devise harder diagnostic tasks where the relative distance of the ideal attention position varies with timestep. In such settings, the simple interpolation trick with relative attention is not sufficient. We introduce novel variants of location attention building on top of Dubois et al. (2020) to address the new diagnostic tasks. We also show the benefits of our approaches for length generalization in SCAN (Lake & Baroni, 2018) and CFQ (Keysers et al., 2020). Our code is available on GitHub.

In recent years, exploiting the domain-specific underlying structure of data and its generative factors for representation learning has shown success in various use-case agnostic applications. However, the diversity and complexity of tabular data have made it challenging to represent these structures in a latent space through multi-dimensional vectors. We design an autoencoder-based framework for building general purpose embeddings, we assess the performance of different autoencoder architectures, and show simpler models outperform complex ones in embedding highly complex tabular data. We apply our framework to produce plug-and-play, rich, and anonymized embeddings representing AWS customers for usage in any model, saving up to 45% of development time, and observe significant improvements in downstream models. Moreover, we propose a significant improvement to the calculation of reconstruction loss for multi-layer contractive autoencoders (CAE) by calculating the Jacobian of the entire encoder leading to a 15% improvement in reconstruction quality when compared to a stacked CAE.

Language-supervised pre-training has proven to be a valuable method for extracting semantically meaningful features from images, serving as a foundational element in multimodal systems within the computer vision and medical imaging domains. However, resulting features are limited by the information contained within the text. This is particularly problematic in medical imaging, where radiologists' written findings focus on specific observations; a challenge compounded by the scarcity of paired imaging-text data due to concerns over leakage of personal health information. In this work, we fundamentally challenge the prevailing reliance on language supervision for learning general purpose biomedical imaging encoders. We introduce RAD-DINO, a biomedical image encoder pre-trained solely on unimodal biomedical imaging data that obtains similar or greater performance than state-of-the-art biomedical language supervised models on a diverse range of benchmarks. Specifically, the quality of learned representations is evaluated on standard imaging tasks (classification and semantic segmentation), and a vision-language alignment task (text report generation from images). To further demonstrate the drawback of language supervision, we show that features from RAD-DINO correlate with other medical records (e.g., sex or age) better than language-supervised models, which are generally not mentioned in radiology reports. Finally, we conduct a series of ablations determining the factors in RAD-DINO's performance; notably, we observe that RAD-DINO's downstream performance scales well with the quantity and diversity of training data, demonstrating that image-only supervision is a scalable approach for training a foundational biomedical image encoder.

Transformers rely on both content-based and position-based addressing mechanisms to make predictions, but existing positional encoding techniques often diminish the effectiveness of position-based addressing. Many current methods enforce rigid patterns in attention maps, limiting the ability to model long-range dependencies and adapt to diverse tasks. Additionally, most positional encodings are learned as general biases, lacking the specialization required for different instances within a dataset. To address this, we propose conTextualized equivariAnt Position Embedding (TAPE), a novel framework that enhances positional embeddings by incorporating sequence content across layers. TAPE introduces dynamic, context-aware positional encodings, overcoming the constraints of traditional fixed patterns. By enforcing permutation and orthogonal equivariance, TAPE ensures the stability of positional encodings during updates, improving robustness and adaptability. Our method can be easily integrated into pre-trained transformers, offering parameter-efficient fine-tuning with minimal overhead. Extensive experiments shows that TAPE achieves superior performance in language modeling, arithmetic reasoning, and long-context retrieval tasks compared to existing positional embedding techniques.

State-of-the-art methods for conditional average treatment effect (CATE) estimation make widespread use of representation learning. Here, the idea is to reduce the variance of the low-sample CATE estimation by a (potentially constrained) low-dimensional representation. However, low-dimensional representations can lose information about the observed confounders and thus lead to bias, because of which the validity of representation learning for CATE estimation is typically violated. In this paper, we propose a new, representation-agnostic framework for estimating bounds on the representation-induced confounding bias that comes from dimensionality reduction (or other constraints on the representations) in CATE estimation. First, we establish theoretically under which conditions CATEs are non-identifiable given low-dimensional (constrained) representations. Second, as our remedy, we propose to perform partial identification of CATEs or, equivalently, aim at estimating of lower and upper bounds of the representation-induced confounding bias. We demonstrate the effectiveness of our bounds in a series of experiments. In sum, our framework is of direct relevance in practice where the validity of CATE estimation is of importance.

Anatomical segmentation is a fundamental task in medical image computing, generally tackled with fully convolutional neural networks which produce dense segmentation masks. These models are often trained with loss functions such as cross-entropy or Dice, which assume pixels to be independent of each other, thus ignoring topological errors and anatomical inconsistencies. We address this limitation by moving from pixel-level to graph representations, which allow to naturally incorporate anatomical constraints by construction. To this end, we introduce HybridGNet, an encoder-decoder neural architecture that leverages standard convolutions for image feature encoding and graph convolutional neural networks (GCNNs) to decode plausible representations of anatomical structures. We also propose a novel image-to-graph skip connection layer which allows localized features to flow from standard convolutional blocks to GCNN blocks, and show that it improves segmentation accuracy. The proposed architecture is extensively evaluated in a variety of domain shift and image occlusion scenarios, and audited considering different types of demographic domain shift. Our comprehensive experimental setup compares HybridGNet with other landmark and pixel-based models for anatomical segmentation in chest x-ray images, and shows that it produces anatomically plausible results in challenging scenarios where other models tend to fail.

Fr\'echet Inception Distance (FID) is the primary metric for ranking models in data-driven generative modeling. While remarkably successful, the metric is known to sometimes disagree with human judgement. We investigate a root cause of these discrepancies, and visualize what FID "looks at" in generated images. We show that the feature space that FID is (typically) computed in is so close to the ImageNet classifications that aligning the histograms of Top-N classifications between sets of generated and real images can reduce FID substantially -- without actually improving the quality of results. Thus, we conclude that FID is prone to intentional or accidental distortions. As a practical example of an accidental distortion, we discuss a case where an ImageNet pre-trained FastGAN achieves a FID comparable to StyleGAN2, while being worse in terms of human evaluation.

Text-guided diffusion models (TDMs) are widely applied but can fail unexpectedly. Common failures include: (i) natural-looking text prompts generating images with the wrong content, or (ii) different random samples of the latent variables that generate vastly different, and even unrelated, outputs despite being conditioned on the same text prompt. In this work, we aim to study and understand the failure modes of TDMs in more detail. To achieve this, we propose SAGE, the first adversarial search method on TDMs that systematically explores the discrete prompt space and the high-dimensional latent space, to automatically discover undesirable behaviors and failure cases in image generation. We use image classifiers as surrogate loss functions during searching, and employ human inspections to validate the identified failures. For the first time, our method enables efficient exploration of both the discrete and intricate human language space and the challenging latent space, overcoming the gradient vanishing problem. Then, we demonstrate the effectiveness of SAGE on five widely used generative models and reveal four typical failure modes: (1) We find a variety of natural text prompts that generate images failing to capture the semantics of input texts. We further discuss the underlying causes and potential solutions based on the results. (2) We find regions in the latent space that lead to distorted images independent of the text prompt, suggesting that parts of the latent space are not well-structured. (3) We also find latent samples that result in natural-looking images unrelated to the text prompt, implying a possible misalignment between the latent and prompt spaces. (4) By appending a single adversarial token embedding to any input prompts, we can generate a variety of specified target objects. Project page: https://sage-diffusion.github.io/

Language-image pre-training is an effective technique for learning powerful representations in general domains. However, when directly turning to person representation learning, these general pre-training methods suffer from unsatisfactory performance. The reason is that they neglect critical person-related characteristics, i.e., fine-grained attributes and identities. To address this issue, we propose a novel language-image pre-training framework for person representation learning, termed PLIP. Specifically, we elaborately design three pretext tasks: 1) Text-guided Image Colorization, aims to establish the correspondence between the person-related image regions and the fine-grained color-part textual phrases. 2) Image-guided Attributes Prediction, aims to mine fine-grained attribute information of the person body in the image; and 3) Identity-based Vision-Language Contrast, aims to correlate the cross-modal representations at the identity level rather than the instance level. Moreover, to implement our pre-train framework, we construct a large-scale person dataset with image-text pairs named SYNTH-PEDES by automatically generating textual annotations. We pre-train PLIP on SYNTH-PEDES and evaluate our models by spanning downstream person-centric tasks. PLIP not only significantly improves existing methods on all these tasks, but also shows great ability in the zero-shot and domain generalization settings. The code, dataset and weights will be released at~https://github.com/Zplusdragon/PLIP

Computed tomography (CT) serves as an effective tool for lung cancer screening, diagnosis, treatment, and prognosis, providing a rich source of features to quantify temporal and spatial tumor changes. Nonetheless, the diversity of CT scanners and customized acquisition protocols can introduce significant inconsistencies in texture features, even when assessing the same patient. This variability poses a fundamental challenge for subsequent research that relies on consistent image features. Existing CT image standardization models predominantly utilize GAN-based supervised or semi-supervised learning, but their performance remains limited. We present DiffusionCT, an innovative score-based DDPM model that operates in the latent space to transform disparate non-standard distributions into a standardized form. The architecture comprises a U-Net-based encoder-decoder, augmented by a DDPM model integrated at the bottleneck position. First, the encoder-decoder is trained independently, without embedding DDPM, to capture the latent representation of the input data. Second, the latent DDPM model is trained while keeping the encoder-decoder parameters fixed. Finally, the decoder uses the transformed latent representation to generate a standardized CT image, providing a more consistent basis for downstream analysis. Empirical tests on patient CT images indicate notable improvements in image standardization using DiffusionCT. Additionally, the model significantly reduces image noise in SPAD images, further validating the effectiveness of DiffusionCT for advanced imaging tasks.

Convolutional neural networks are capable of learning powerful representational spaces, which are necessary for tackling complex learning tasks. However, due to the model capacity required to capture such representations, they are often susceptible to overfitting and therefore require proper regularization in order to generalize well. In this paper, we show that the simple regularization technique of randomly masking out square regions of input during training, which we call cutout, can be used to improve the robustness and overall performance of convolutional neural networks. Not only is this method extremely easy to implement, but we also demonstrate that it can be used in conjunction with existing forms of data augmentation and other regularizers to further improve model performance. We evaluate this method by applying it to current state-of-the-art architectures on the CIFAR-10, CIFAR-100, and SVHN datasets, yielding new state-of-the-art results of 2.56%, 15.20%, and 1.30% test error respectively. Code is available at https://github.com/uoguelph-mlrg/Cutout

Latent-based image generative models, such as Latent Diffusion Models (LDMs) and Mask Image Models (MIMs), have achieved notable success in image generation tasks. These models typically leverage reconstructive autoencoders like VQGAN or VAE to encode pixels into a more compact latent space and learn the data distribution in the latent space instead of directly from pixels. However, this practice raises a pertinent question: Is it truly the optimal choice? In response, we begin with an intriguing observation: despite sharing the same latent space, autoregressive models significantly lag behind LDMs and MIMs in image generation. This finding contrasts sharply with the field of NLP, where the autoregressive model GPT has established a commanding presence. To address this discrepancy, we introduce a unified perspective on the relationship between latent space and generative models, emphasizing the stability of latent space in image generative modeling. Furthermore, we propose a simple but effective discrete image tokenizer to stabilize the latent space for image generative modeling. Experimental results show that image autoregressive modeling with our tokenizer (DiGIT) benefits both image understanding and image generation with the next token prediction principle, which is inherently straightforward for GPT models but challenging for other generative models. Remarkably, for the first time, a GPT-style autoregressive model for images outperforms LDMs, which also exhibits substantial improvement akin to GPT when scaling up model size. Our findings underscore the potential of an optimized latent space and the integration of discrete tokenization in advancing the capabilities of image generative models. The code is available at https://github.com/DAMO-NLP-SG/DiGIT.

Two main families of node feature augmentation schemes have been explored for enhancing GNNs: random features and spectral positional encoding. Surprisingly, however, there is still no clear understanding of the relation between these two augmentation schemes. Here we propose a novel family of positional encoding schemes which draws a link between the above two approaches and improves over both. The new approach, named Random Feature Propagation (RFP), is inspired by the power iteration method and its generalizations. It concatenates several intermediate steps of an iterative algorithm for computing the dominant eigenvectors of a propagation matrix, starting from random node features. Notably, these propagation steps are based on graph-dependent propagation operators that can be either predefined or learned. We explore the theoretical and empirical benefits of RFP. First, we provide theoretical justifications for using random features, for incorporating early propagation steps, and for using multiple random initializations. Then, we empirically demonstrate that RFP significantly outperforms both spectral PE and random features in multiple node classification and graph classification benchmarks.

Current Scene Graph Generation (SGG) methods explore contextual information to predict relationships among entity pairs. However, due to the diverse visual appearance of numerous possible subject-object combinations, there is a large intra-class variation within each predicate category, e.g., "man-eating-pizza, giraffe-eating-leaf", and the severe inter-class similarity between different classes, e.g., "man-holding-plate, man-eating-pizza", in model's latent space. The above challenges prevent current SGG methods from acquiring robust features for reliable relation prediction. In this paper, we claim that the predicate's category-inherent semantics can serve as class-wise prototypes in the semantic space for relieving the challenges. To the end, we propose the Prototype-based Embedding Network (PE-Net), which models entities/predicates with prototype-aligned compact and distinctive representations and thereby establishes matching between entity pairs and predicates in a common embedding space for relation recognition. Moreover, Prototype-guided Learning (PL) is introduced to help PE-Net efficiently learn such entitypredicate matching, and Prototype Regularization (PR) is devised to relieve the ambiguous entity-predicate matching caused by the predicate's semantic overlap. Extensive experiments demonstrate that our method gains superior relation recognition capability on SGG, achieving new state-of-the-art performances on both Visual Genome and Open Images datasets.

Latent diffusion models have become the popular choice for scaling up diffusion models for high resolution image synthesis. Compared to pixel-space models that are trained end-to-end, latent models are perceived to be more efficient and to produce higher image quality at high resolution. Here we challenge these notions, and show that pixel-space models can in fact be very competitive to latent approaches both in quality and efficiency, achieving 1.5 FID on ImageNet512 and new SOTA results on ImageNet128 and ImageNet256. We present a simple recipe for scaling end-to-end pixel-space diffusion models to high resolutions. 1: Use the sigmoid loss (Kingma & Gao, 2023) with our prescribed hyper-parameters. 2: Use our simplified memory-efficient architecture with fewer skip-connections. 3: Scale the model to favor processing the image at high resolution with fewer parameters, rather than using more parameters but at a lower resolution. When combining these three steps with recently proposed tricks like guidance intervals, we obtain a family of pixel-space diffusion models we call Simple Diffusion v2 (SiD2).

We propose a new method for solving imaging inverse problems using text-to-image latent diffusion models as general priors. Existing methods using latent diffusion models for inverse problems typically rely on simple null text prompts, which can lead to suboptimal performance. To address this limitation, we introduce a method for prompt tuning, which jointly optimizes the text embedding on-the-fly while running the reverse diffusion process. This allows us to generate images that are more faithful to the diffusion prior. In addition, we propose a method to keep the evolution of latent variables within the range space of the encoder, by projection. This helps to reduce image artifacts, a major problem when using latent diffusion models instead of pixel-based diffusion models. Our combined method, called P2L, outperforms both image- and latent-diffusion model-based inverse problem solvers on a variety of tasks, such as super-resolution, deblurring, and inpainting.

Diffusion models have become a cornerstone in image editing, offering flexibility with language prompts and source images. However, a key challenge is attribute leakage, where unintended modifications occur in non-target regions or within target regions due to attribute interference. Existing methods often suffer from leakage due to naive text embeddings and inadequate handling of End-of-Sequence (EOS) token embeddings. To address this, we propose ALE-Edit (Attribute-leakage-free editing), a novel framework to minimize attribute leakage with three components: (1) Object-Restricted Embeddings (ORE) to localize object-specific attributes in text embeddings, (2) Region-Guided Blending for Cross-Attention Masking (RGB-CAM) to align attention with target regions, and (3) Background Blending (BB) to preserve non-edited regions. Additionally, we introduce ALE-Bench, a benchmark for evaluating attribute leakage with new metrics for target-external and target-internal leakage. Experiments demonstrate that our framework significantly reduces attribute leakage while maintaining high editing quality, providing an efficient and tuning-free solution for multi-object image editing.

Position bias has proven to be a prevalent issue of modern language models (LMs), where the models prioritize content based on its position within the given context. This bias often leads to unexpected model failures and hurts performance, robustness, and reliability across various applications. Our mechanistic analysis attributes the position bias to two components employed in nearly all state-of-the-art LMs: causal attention and relative positional encodings. Specifically, we find that causal attention generally causes models to favor distant content, while relative positional encodings like RoPE prefer nearby ones based on the analysis of retrieval-augmented question answering (QA). Further, our empirical study on object detection reveals that position bias is also present in vision-language models (VLMs). Based on the above analyses, we propose to ELIMINATE position bias caused by different input segment orders (e.g., options in LM-as-a-judge, retrieved documents in QA) in a TRAINING-FREE ZERO-SHOT manner. Our method changes the causal attention to bidirectional attention between segments and utilizes model attention values to decide the relative orders of segments instead of using the order provided in input prompts, therefore enabling Position-INvariant inferencE (PINE) at the segment level. By eliminating position bias, models achieve better performance and reliability in downstream tasks where position bias widely exists, such as LM-as-a-judge and retrieval-augmented QA. Notably, PINE is especially useful when adapting LMs for evaluating reasoning pairs: it consistently provides 8 to 10 percentage points performance gains in most cases, and makes Llama-3-70B-Instruct perform even better than GPT-4-0125-preview on the RewardBench reasoning subset.

The Segment Anything Model (SAM) has achieved remarkable successes in the realm of natural image segmentation, but its deployment in the medical imaging sphere has encountered challenges. Specifically, the model struggles with medical images that feature low contrast, faint boundaries, intricate morphologies, and small-sized objects. To address these challenges and enhance SAM's performance in the medical domain, we introduce a comprehensive modification. Firstly, we incorporate a frozen Convolutional Neural Network (CNN) branch as an image encoder, which synergizes with SAM's original Vision Transformer (ViT) encoder through a novel variational attention fusion module. This integration bolsters the model's capability to capture local spatial information, which is often paramount in medical imagery. Moreover, to further optimize SAM for medical imaging, we introduce feature and position adapters within the ViT branch, refining the encoder's representations. We see that compared to current prompting strategies to fine-tune SAM for ultrasound medical segmentation, the use of text descriptions that serve as text prompts for SAM helps significantly improve the performance. Leveraging ChatGPT's natural language understanding capabilities, we generate prompts that offer contextual information and guidance to SAM, enabling it to better understand the nuances of ultrasound medical images and improve its segmentation accuracy. Our method, in its entirety, represents a significant stride towards making universal image segmentation models more adaptable and efficient in the medical domain.

Magnetic Resonance Imaging (MRI) is a widely-accepted imaging technique for knee injury analysis. Its advantage of capturing knee structure in three dimensions makes it the ideal tool for radiologists to locate potential tears in the knee. In order to better confront the ever growing workload of musculoskeletal (MSK) radiologists, automated tools for patients' triage are becoming a real need, reducing delays in the reading of pathological cases. In this work, we present the Efficiently-Layered Network (ELNet), a convolutional neural network (CNN) architecture optimized for the task of initial knee MRI diagnosis for triage. Unlike past approaches, we train ELNet from scratch instead of using a transfer-learning approach. The proposed method is validated quantitatively and qualitatively, and compares favorably against state-of-the-art MRNet while using a single imaging stack (axial or coronal) as input. Additionally, we demonstrate our model's capability to locate tears in the knee despite the absence of localization information during training. Lastly, the proposed model is extremely lightweight (< 1MB) and therefore easy to train and deploy in real clinical settings. The code for our model is provided at: https://github.com/mxtsai/ELNet.

Medical image classification in radiology faces significant challenges, particularly in generalizing to unseen pathologies. In contrast, CLIP offers a promising solution by leveraging multimodal learning to improve zero-shot classification performance. However, in the medical domain, lesions can be small and might not be well represented in the embedding space. Therefore, in this paper, we explore the potential of visual prompt engineering to enhance the capabilities of Vision Language Models (VLMs) in radiology. Leveraging BiomedCLIP, trained on extensive biomedical image-text pairs, we investigate the impact of embedding visual markers directly within radiological images to guide the model's attention to critical regions. Our evaluation on the JSRT dataset, focusing on lung nodule malignancy classification, demonstrates that incorporating visual prompts x2013 such as arrows, circles, and contours x2013 significantly improves classification metrics including AUROC, AUPRC, F1 score, and accuracy. Moreover, the study provides attention maps, showcasing enhanced model interpretability and focus on clinically relevant areas. These findings underscore the efficacy of visual prompt engineering as a straightforward yet powerful approach to advance VLM performance in medical image analysis.

Structured dropout approaches, such as attention dropout and DropHead, have been investigated to regularize the multi-head attention mechanism in Transformers. In this paper, we propose a new regularization scheme based on token-level rather than structure-level to reduce overfitting. Specifically, we devise a novel Token-Level Masking (TLM) training strategy for Transformers to regularize the connections of self-attention, which consists of two masking techniques that are effective and easy to implement. The underlying idea is to manipulate the connections between tokens in the multi-head attention via masking, where the networks are forced to exploit partial neighbors' information to produce a meaningful representation. The generality and effectiveness of TLM are thoroughly evaluated via extensive experiments on 4 diversified NLP tasks across 18 datasets, including natural language understanding benchmark GLUE, ChineseGLUE, Chinese Grammatical Error Correction, and data-to-text generation. The results indicate that TLM can consistently outperform attention dropout and DropHead, e.g., it increases by 0.5 points relative to DropHead with BERT-large on GLUE. Moreover, TLM can establish a new record on the data-to-text benchmark Rotowire (18.93 BLEU). Our code will be publicly available at https://github.com/Young1993/tlm.

While likelihood-based generative models, particularly diffusion and autoregressive models, have achieved remarkable fidelity in visual generation, the maximum likelihood estimation (MLE) objective inherently suffers from a mode-covering tendency that limits the generation quality under limited model capacity. In this work, we propose Direct Discriminative Optimization (DDO) as a unified framework that bridges likelihood-based generative training and the GAN objective to bypass this fundamental constraint. Our key insight is to parameterize a discriminator implicitly using the likelihood ratio between a learnable target model and a fixed reference model, drawing parallels with the philosophy of Direct Preference Optimization (DPO). Unlike GANs, this parameterization eliminates the need for joint training of generator and discriminator networks, allowing for direct, efficient, and effective finetuning of a well-trained model to its full potential beyond the limits of MLE. DDO can be performed iteratively in a self-play manner for progressive model refinement, with each round requiring less than 1% of pretraining epochs. Our experiments demonstrate the effectiveness of DDO by significantly advancing the previous SOTA diffusion model EDM, reducing FID scores from 1.79/1.58 to new records of 1.30/0.97 on CIFAR-10/ImageNet-64 datasets, and by consistently improving both guidance-free and CFG-enhanced FIDs of visual autoregressive models on ImageNet 256times256.

Image attribution algorithms aim to identify important regions that are highly relevant to model decisions. Although existing attribution solutions can effectively assign importance to target elements, they still face the following challenges: 1) existing attribution methods generate inaccurate small regions thus misleading the direction of correct attribution, and 2) the model cannot produce good attribution results for samples with wrong predictions. To address the above challenges, this paper re-models the above image attribution problem as a submodular subset selection problem, aiming to enhance model interpretability using fewer regions. To address the lack of attention to local regions, we construct a novel submodular function to discover more accurate small interpretation regions. To enhance the attribution effect for all samples, we also impose four different constraints on the selection of sub-regions, i.e., confidence, effectiveness, consistency, and collaboration scores, to assess the importance of various subsets. Moreover, our theoretical analysis substantiates that the proposed function is in fact submodular. Extensive experiments show that the proposed method outperforms SOTA methods on two face datasets (Celeb-A and VGG-Face2) and one fine-grained dataset (CUB-200-2011). For correctly predicted samples, the proposed method improves the Deletion and Insertion scores with an average of 4.9% and 2.5% gain relative to HSIC-Attribution. For incorrectly predicted samples, our method achieves gains of 81.0% and 18.4% compared to the HSIC-Attribution algorithm in the average highest confidence and Insertion score respectively. The code is released at https://github.com/RuoyuChen10/SMDL-Attribution.

Understanding the workflow of surgical procedures in complex operating rooms requires a deep understanding of the interactions between clinicians and their environment. Surgical activity recognition (SAR) is a key computer vision task that detects activities or phases from multi-view camera recordings. Existing SAR models often fail to account for fine-grained clinician movements and multi-view knowledge, or they require calibrated multi-view camera setups and advanced point-cloud processing to obtain better results. In this work, we propose a novel calibration-free multi-view multi-modal pretraining framework called Multiview Pretraining for Video-Pose Surgical Activity Recognition PreViPS, which aligns 2D pose and vision embeddings across camera views. Our model follows CLIP-style dual-encoder architecture: one encoder processes visual features, while the other encodes human pose embeddings. To handle the continuous 2D human pose coordinates, we introduce a tokenized discrete representation to convert the continuous 2D pose coordinates into discrete pose embeddings, thereby enabling efficient integration within the dual-encoder framework. To bridge the gap between these two modalities, we propose several pretraining objectives using cross- and in-modality geometric constraints within the embedding space and incorporating masked pose token prediction strategy to enhance representation learning. Extensive experiments and ablation studies demonstrate improvements over the strong baselines, while data-efficiency experiments on two distinct operating room datasets further highlight the effectiveness of our approach. We highlight the benefits of our approach for surgical activity recognition in both multi-view and single-view settings, showcasing its practical applicability in complex surgical environments. Code will be made available at: https://github.com/CAMMA-public/PreViPS.

With the incorporation of the UNet architecture, diffusion probabilistic models have become a dominant force in image generation tasks. One key design in UNet is the skip connections between the encoder and decoder blocks. Although skip connections have been shown to improve training stability and model performance, we reveal that such shortcuts can be a limiting factor for the complexity of the transformation. As the sampling steps decrease, the generation process and the role of the UNet get closer to the push-forward transformations from Gaussian distribution to the target, posing a challenge for the network's complexity. To address this challenge, we propose Skip-Tuning, a simple yet surprisingly effective training-free tuning method on the skip connections. Our method can achieve 100% FID improvement for pretrained EDM on ImageNet 64 with only 19 NFEs (1.75), breaking the limit of ODE samplers regardless of sampling steps. Surprisingly, the improvement persists when we increase the number of sampling steps and can even surpass the best result from EDM-2 (1.58) with only 39 NFEs (1.57). Comprehensive exploratory experiments are conducted to shed light on the surprising effectiveness. We observe that while Skip-Tuning increases the score-matching losses in the pixel space, the losses in the feature space are reduced, particularly at intermediate noise levels, which coincide with the most effective range accounting for image quality improvement.

In anomaly segmentation for complex driving scenes, state-of-the-art approaches utilize anomaly scoring functions to calculate anomaly scores. For these functions, accurately predicting the logits of inlier classes for each pixel is crucial for precisely inferring the anomaly score. However, in real-world driving scenarios, the diversity of scenes often results in distorted manifolds of pixel embeddings in the space. This effect is not conducive to directly using the pixel embeddings for the logit prediction during inference, a concern overlooked by existing methods. To address this problem, we propose a novel method called Random Walk on Pixel Manifolds (RWPM). RWPM utilizes random walks to reveal the intrinsic relationships among pixels to refine the pixel embeddings. The refined pixel embeddings alleviate the distortion of manifolds, improving the accuracy of anomaly scores. Our extensive experiments show that RWPM consistently improve the performance of the existing anomaly segmentation methods and achieve the best results. Code is available at: https://github.com/ZelongZeng/RWPM.

Model selection/optimization in conformal inference is challenging, since it may break the exchangeability between labeled and unlabeled data. We study this problem in the context of conformal selection, which uses conformal p-values to select ``interesting'' instances with large unobserved labels from a pool of unlabeled data, while controlling the FDR in finite sample. For validity, existing solutions require the model choice to be independent of the data used to construct the p-values and calibrate the selection set. However, when presented with many model choices and limited labeled data, it is desirable to (i) select the best model in a data-driven manner, and (ii) mitigate power loss due to sample splitting. This paper presents OptCS, a general framework that allows valid statistical testing (selection) after flexible data-driven model optimization. We introduce general conditions under which OptCS constructs valid conformal p-values despite substantial data reuse and handles complex p-value dependencies to maintain finite-sample FDR control via a novel multiple testing procedure. We instantiate this general recipe to propose three FDR-controlling procedures, each optimizing the models differently: (i) selecting the most powerful one among multiple pre-trained candidate models, (ii) using all data for model fitting without sample splitting, and (iii) combining full-sample model fitting and selection. We demonstrate the efficacy of our methods via simulation studies and real applications in drug discovery and alignment of large language models in radiology report generation.

Electronic health record (EHR) systems are used extensively throughout the healthcare domain. However, data interchangeability between EHR systems is limited due to the use of different coding standards across systems. Existing methods of mapping coding standards based on manual human experts mapping, dictionary mapping, symbolic NLP and classification are unscalable and cannot accommodate large scale EHR datasets. In this work, we present Text2Node, a cross-domain mapping system capable of mapping medical phrases to concepts in a large taxonomy (such as SNOMED CT). The system is designed to generalize from a limited set of training samples and map phrases to elements of the taxonomy that are not covered by training data. As a result, our system is scalable, robust to wording variants between coding systems and can output highly relevant concepts when no exact concept exists in the target taxonomy. Text2Node operates in three main stages: first, the lexicon is mapped to word embeddings; second, the taxonomy is vectorized using node embeddings; and finally, the mapping function is trained to connect the two embedding spaces. We compared multiple algorithms and architectures for each stage of the training, including GloVe and FastText word embeddings, CNN and Bi-LSTM mapping functions, and node2vec for node embeddings. We confirmed the robustness and generalisation properties of Text2Node by mapping ICD-9-CM Diagnosis phrases to SNOMED CT and by zero-shot training at comparable accuracy. This system is a novel methodological contribution to the task of normalizing and linking phrases to a taxonomy, advancing data interchangeability in healthcare. When applied, the system can use electronic health records to generate an embedding that incorporates taxonomical medical knowledge to improve clinical predictive models.

Large-scale pre-training tasks like image classification, captioning, or self-supervised techniques do not incentivize learning the semantic boundaries of objects. However, recent generative foundation models built using text-based latent diffusion techniques may learn semantic boundaries. This is because they have to synthesize intricate details about all objects in an image based on a text description. Therefore, we present a technique for segmenting real and AI-generated images using latent diffusion models (LDMs) trained on internet-scale datasets. First, we show that the latent space of LDMs (z-space) is a better input representation compared to other feature representations like RGB images or CLIP encodings for text-based image segmentation. By training the segmentation models on the latent z-space, which creates a compressed representation across several domains like different forms of art, cartoons, illustrations, and photographs, we are also able to bridge the domain gap between real and AI-generated images. We show that the internal features of LDMs contain rich semantic information and present a technique in the form of LD-ZNet to further boost the performance of text-based segmentation. Overall, we show up to 6% improvement over standard baselines for text-to-image segmentation on natural images. For AI-generated imagery, we show close to 20% improvement compared to state-of-the-art techniques. The project is available at https://koutilya-pnvr.github.io/LD-ZNet/.

Humans recognize anomalies through two aspects: larger patch-wise representation discrepancies and weaker patch-to-normal-patch correlations. However, the previous AD methods didn't sufficiently combine the two complementary aspects to design AD models. To this end, we find that Transformer can ideally satisfy the two aspects as its great power in the unified modeling of patch-wise representations and patch-to-patch correlations. In this paper, we propose a novel AD framework: FOcus-the-Discrepancy (FOD), which can simultaneously spot the patch-wise, intra- and inter-discrepancies of anomalies. The major characteristic of our method is that we renovate the self-attention maps in transformers to Intra-Inter-Correlation (I2Correlation). The I2Correlation contains a two-branch structure to first explicitly establish intra- and inter-image correlations, and then fuses the features of two-branch to spotlight the abnormal patterns. To learn the intra- and inter-correlations adaptively, we propose the RBF-kernel-based target-correlations as learning targets for self-supervised learning. Besides, we introduce an entropy constraint strategy to solve the mode collapse issue in optimization and further amplify the normal-abnormal distinguishability. Extensive experiments on three unsupervised real-world AD benchmarks show the superior performance of our approach. Code will be available at https://github.com/xcyao00/FOD.

The Segment Anything Model (SAM) has demonstrated outstanding adaptation to medical image segmentation but still faces three major challenges. Firstly, the huge computational costs of SAM limit its real-world applicability. Secondly, SAM depends on manual annotations (e.g., points, boxes) as prompts, which are laborious and impractical in clinical scenarios. Thirdly, SAM handles all segmentation targets equally, which is suboptimal for diverse medical modalities with inherent heterogeneity. To address these issues, we propose an Efficient Self-Prompting SAM for universal medical image segmentation, named ESP-MedSAM. We devise a Multi-Modal Decoupled Knowledge Distillation (MMDKD) strategy to distil common image knowledge and domain-specific medical knowledge from the foundation model to train a lightweight image encoder and a modality controller. Further, they combine with the additionally introduced Self-Patch Prompt Generator (SPPG) and Query-Decoupled Modality Decoder (QDMD) to construct ESP-MedSAM. Specifically, SPPG aims to generate a set of patch prompts automatically and QDMD leverages a one-to-one strategy to provide an independent decoding channel for every modality. Extensive experiments indicate that ESP-MedSAM outperforms state-of-the-arts in diverse medical imaging segmentation takes, displaying superior zero-shot learning and modality transfer ability. Especially, our framework uses only 31.4% parameters compared to SAM-Base.

Current large vision-language models (VLMs) often encounter challenges such as insufficient capabilities of a single visual component and excessively long visual tokens. These issues can limit the model's effectiveness in accurately interpreting complex visual information and over-lengthy contextual information. Addressing these challenges is crucial for enhancing the performance and applicability of VLMs. This paper proposes the use of ensemble experts technique to synergizes the capabilities of individual visual encoders, including those skilled in image-text matching, OCR, image segmentation, etc. This technique introduces a fusion network to unify the processing of outputs from different visual experts, while bridging the gap between image encoders and pre-trained LLMs. In addition, we explore different positional encoding schemes to alleviate the waste of positional encoding caused by lengthy image feature sequences, effectively addressing the issue of position overflow and length limitations. For instance, in our implementation, this technique significantly reduces the positional occupancy in models like SAM, from a substantial 4096 to a more efficient and manageable 64 or even down to 1. Experimental results demonstrate that VLMs with multiple experts exhibit consistently superior performance over isolated visual encoders and mark a significant performance boost as more experts are integrated. We have open-sourced the training code used in this report. All of these resources can be found on our project website.

Multimodal models trained on large natural image-text pair datasets have exhibited astounding abilities in generating high-quality images. Medical imaging data is fundamentally different to natural images, and the language used to succinctly capture relevant details in medical data uses a different, narrow but semantically rich, domain-specific vocabulary. Not surprisingly, multi-modal models trained on natural image-text pairs do not tend to generalize well to the medical domain. Developing generative imaging models faithfully representing medical concepts while providing compositional diversity could mitigate the existing paucity of high-quality, annotated medical imaging datasets. In this work, we develop a strategy to overcome the large natural-medical distributional shift by adapting a pre-trained latent diffusion model on a corpus of publicly available chest x-rays (CXR) and their corresponding radiology (text) reports. We investigate the model's ability to generate high-fidelity, diverse synthetic CXR conditioned on text prompts. We assess the model outputs quantitatively using image quality metrics, and evaluate image quality and text-image alignment by human domain experts. We present evidence that the resulting model (RoentGen) is able to create visually convincing, diverse synthetic CXR images, and that the output can be controlled to a new extent by using free-form text prompts including radiology-specific language. Fine-tuning this model on a fixed training set and using it as a data augmentation method, we measure a 5% improvement of a classifier trained jointly on synthetic and real images, and a 3% improvement when trained on a larger but purely synthetic training set. Finally, we observe that this fine-tuning distills in-domain knowledge in the text-encoder and can improve its representation capabilities of certain diseases like pneumothorax by 25%.

Machine learning models -- including prominent zero-shot models -- are often trained on datasets whose labels are only a small proportion of a larger label space. Such spaces are commonly equipped with a metric that relates the labels via distances between them. We propose a simple approach to exploit this information to adapt the trained model to reliably predict new classes -- or, in the case of zero-shot prediction, to improve its performance -- without any additional training. Our technique is a drop-in replacement of the standard prediction rule, swapping argmax with the Fr\'echet mean. We provide a comprehensive theoretical analysis for this approach, studying (i) learning-theoretic results trading off label space diameter, sample complexity, and model dimension, (ii) characterizations of the full range of scenarios in which it is possible to predict any unobserved class, and (iii) an optimal active learning-like next class selection procedure to obtain optimal training classes for when it is not possible to predict the entire range of unobserved classes. Empirically, using easily-available external metrics, our proposed approach, Loki, gains up to 29.7% relative improvement over SimCLR on ImageNet and scales to hundreds of thousands of classes. When no such metric is available, Loki can use self-derived metrics from class embeddings and obtains a 10.5% improvement on pretrained zero-shot models such as CLIP.

Zero-Shot Anomaly Detection (ZSAD) is an emerging AD paradigm. Unlike the traditional unsupervised AD setting that requires a large number of normal samples to train a model, ZSAD is more practical for handling data-restricted real-world scenarios. Recently, Multimodal Large Language Models (MLLMs) have shown revolutionary reasoning capabilities in various vision tasks. However, the reasoning of image abnormalities remains underexplored due to the lack of corresponding datasets and benchmarks. To facilitate research in AD & reasoning, we establish the first visual instruction tuning dataset, Anomaly-Instruct-125k, and the evaluation benchmark, VisA-D&R. Through investigation with our benchmark, we reveal that current MLLMs like GPT-4o cannot accurately detect and describe fine-grained anomalous details in images. To address this, we propose Anomaly-OneVision (Anomaly-OV), the first specialist visual assistant for ZSAD and reasoning. Inspired by human behavior in visual inspection, Anomaly-OV leverages a Look-Twice Feature Matching (LTFM) mechanism to adaptively select and emphasize abnormal visual tokens. Extensive experiments demonstrate that Anomaly-OV achieves significant improvements over advanced generalist models in both detection and reasoning. Extensions to medical and 3D AD are provided for future study. The link to our project page: https://xujiacong.github.io/Anomaly-OV/

While contrastive learning is proven to be an effective training strategy in computer vision, Natural Language Processing (NLP) is only recently adopting it as a self-supervised alternative to Masked Language Modeling (MLM) for improving sequence representations. This paper introduces SupCL-Seq, which extends the supervised contrastive learning from computer vision to the optimization of sequence representations in NLP. By altering the dropout mask probability in standard Transformer architectures, for every representation (anchor), we generate augmented altered views. A supervised contrastive loss is then utilized to maximize the system's capability of pulling together similar samples (e.g., anchors and their altered views) and pushing apart the samples belonging to the other classes. Despite its simplicity, SupCLSeq leads to large gains in many sequence classification tasks on the GLUE benchmark compared to a standard BERTbase, including 6% absolute improvement on CoLA, 5.4% on MRPC, 4.7% on RTE and 2.6% on STSB. We also show consistent gains over self supervised contrastively learned representations, especially in non-semantic tasks. Finally we show that these gains are not solely due to augmentation, but rather to a downstream optimized sequence representation. Code: https://github.com/hooman650/SupCL-Seq

Text-to-image (T2I) diffusion models rely on encoded prompts to guide the image generation process. Typically, these prompts are extended to a fixed length by adding padding tokens before text encoding. Despite being a default practice, the influence of padding tokens on the image generation process has not been investigated. In this work, we conduct the first in-depth analysis of the role padding tokens play in T2I models. We develop two causal techniques to analyze how information is encoded in the representation of tokens across different components of the T2I pipeline. Using these techniques, we investigate when and how padding tokens impact the image generation process. Our findings reveal three distinct scenarios: padding tokens may affect the model's output during text encoding, during the diffusion process, or be effectively ignored. Moreover, we identify key relationships between these scenarios and the model's architecture (cross or self-attention) and its training process (frozen or trained text encoder). These insights contribute to a deeper understanding of the mechanisms of padding tokens, potentially informing future model design and training practices in T2I systems.

The detailed images produced by Magnetic Resonance Imaging (MRI) provide life-critical information for the diagnosis and treatment of prostate cancer. To provide standardized acquisition, interpretation and usage of the complex MRI images, the PI-RADS v2 guideline was proposed. An automated segmentation following the guideline facilitates consistent and precise lesion detection, staging and treatment. The guideline recommends a division of the prostate into four zones, PZ (peripheral zone), TZ (transition zone), DPU (distal prostatic urethra) and AFS (anterior fibromuscular stroma). Not every zone shares a boundary with the others and is present in every slice. Further, the representations captured by a single model might not suffice for all zones. This motivated us to design a dual-branch convolutional neural network (CNN), where each branch captures the representations of the connected zones separately. Further, the representations from different branches act complementary to each other at the second stage of training, where they are fine-tuned through an unsupervised loss. The loss penalises the difference in predictions from the two branches for the same class. We also incorporate multi-task learning in our framework to further improve the segmentation accuracy. The proposed approach improves the segmentation accuracy of the baseline (mean absolute symmetric distance) by 7.56%, 11.00%, 58.43% and 19.67% for PZ, TZ, DPU and AFS zones respectively.

Recent advancements in text-to-image diffusion models have shown remarkable creative capabilities with textual prompts, but generating personalized instances based on specific subjects, known as subject-driven generation, remains challenging. To tackle this issue, we present a new hybrid framework called HybridBooth, which merges the benefits of optimization-based and direct-regression methods. HybridBooth operates in two stages: the Word Embedding Probe, which generates a robust initial word embedding using a fine-tuned encoder, and the Word Embedding Refinement, which further adapts the encoder to specific subject images by optimizing key parameters. This approach allows for effective and fast inversion of visual concepts into textual embedding, even from a single image, while maintaining the model's generalization capabilities.

Sampling from diffusion probabilistic models (DPMs) is often expensive for high-quality image generation and typically requires many steps with a large model. In this paper, we introduce sampling Trajectory Stitching T-Stitch, a simple yet efficient technique to improve the sampling efficiency with little or no generation degradation. Instead of solely using a large DPM for the entire sampling trajectory, T-Stitch first leverages a smaller DPM in the initial steps as a cheap drop-in replacement of the larger DPM and switches to the larger DPM at a later stage. Our key insight is that different diffusion models learn similar encodings under the same training data distribution and smaller models are capable of generating good global structures in the early steps. Extensive experiments demonstrate that T-Stitch is training-free, generally applicable for different architectures, and complements most existing fast sampling techniques with flexible speed and quality trade-offs. On DiT-XL, for example, 40% of the early timesteps can be safely replaced with a 10x faster DiT-S without performance drop on class-conditional ImageNet generation. We further show that our method can also be used as a drop-in technique to not only accelerate the popular pretrained stable diffusion (SD) models but also improve the prompt alignment of stylized SD models from the public model zoo. Code is released at https://github.com/NVlabs/T-Stitch

Vector quantization (VQ) based ANN indexes, such as Inverted File System (IVF) and Product Quantization (PQ), have been widely applied to embedding based document retrieval thanks to the competitive time and memory efficiency. Originally, VQ is learned to minimize the reconstruction loss, i.e., the distortions between the original dense embeddings and the reconstructed embeddings after quantization. Unfortunately, such an objective is inconsistent with the goal of selecting ground-truth documents for the input query, which may cause severe loss of retrieval quality. Recent works identify such a defect, and propose to minimize the retrieval loss through contrastive learning. However, these methods intensively rely on queries with ground-truth documents, whose performance is limited by the insufficiency of labeled data. In this paper, we propose Distill-VQ, which unifies the learning of IVF and PQ within a knowledge distillation framework. In Distill-VQ, the dense embeddings are leveraged as "teachers", which predict the query's relevance to the sampled documents. The VQ modules are treated as the "students", which are learned to reproduce the predicted relevance, such that the reconstructed embeddings may fully preserve the retrieval result of the dense embeddings. By doing so, Distill-VQ is able to derive substantial training signals from the massive unlabeled data, which significantly contributes to the retrieval quality. We perform comprehensive explorations for the optimal conduct of knowledge distillation, which may provide useful insights for the learning of VQ based ANN index. We also experimentally show that the labeled data is no longer a necessity for high-quality vector quantization, which indicates Distill-VQ's strong applicability in practice.

Prostate cancer, a growing global health concern, necessitates precise diagnostic tools, with Magnetic Resonance Imaging (MRI) offering high-resolution soft tissue imaging that significantly enhances diagnostic accuracy. Recent advancements in explainable AI and representation learning have significantly improved prostate cancer diagnosis by enabling automated and precise lesion classification. However, existing explainable AI methods, particularly those based on frameworks like generative adversarial networks (GANs), are predominantly developed for natural image generation, and their application to medical imaging often leads to suboptimal performance due to the unique characteristics and complexity of medical image. To address these challenges, our paper introduces three key contributions. First, we propose ProjectedEx, a generative framework that provides interpretable, multi-attribute explanations, effectively linking medical image features to classifier decisions. Second, we enhance the encoder module by incorporating feature pyramids, which enables multiscale feedback to refine the latent space and improves the quality of generated explanations. Additionally, we conduct comprehensive experiments on both the generator and classifier, demonstrating the clinical relevance and effectiveness of ProjectedEx in enhancing interpretability and supporting the adoption of AI in medical settings. Code will be released at https://github.com/Richardqiyi/ProjectedEx

Semi-Supervised Semantic Segmentation (S4) aims to train a segmentation model with limited labeled images and a substantial volume of unlabeled images. To improve the robustness of representations, powerful methods introduce a pixel-wise contrastive learning approach in latent space (i.e., representation space) that aggregates the representations to their prototypes in a fully supervised manner. However, previous contrastive-based S4 methods merely rely on the supervision from the model's output (logits) in logit space during unlabeled training. In contrast, we utilize the outputs in both logit space and representation space to obtain supervision in a collaborative way. The supervision from two spaces plays two roles: 1) reduces the risk of over-fitting to incorrect semantic information in logits with the help of representations; 2) enhances the knowledge exchange between the two spaces. Furthermore, unlike previous approaches, we use the similarity between representations and prototypes as a new indicator to tilt training those under-performing representations and achieve a more efficient contrastive learning process. Results on two public benchmarks demonstrate the competitive performance of our method compared with state-of-the-art methods.

In this paper, we consider enhancing medical visual-language pre-training (VLP) with domain-specific knowledge, by exploiting the paired image-text reports from the radiological daily practice. In particular, we make the following contributions: First, unlike existing works that directly process the raw reports, we adopt a novel triplet extraction module to extract the medical-related information, avoiding unnecessary complexity from language grammar and enhancing the supervision signals; Second, we propose a novel triplet encoding module with entity translation by querying a knowledge base, to exploit the rich domain knowledge in medical field, and implicitly build relationships between medical entities in the language embedding space; Third, we propose to use a Transformer-based fusion model for spatially aligning the entity description with visual signals at the image patch level, enabling the ability for medical diagnosis; Fourth, we conduct thorough experiments to validate the effectiveness of our architecture, and benchmark on numerous public benchmarks, e.g., ChestX-ray14, RSNA Pneumonia, SIIM-ACR Pneumothorax, COVIDx CXR-2, COVID Rural, and EdemaSeverity. In both zero-shot and fine-tuning settings, our model has demonstrated strong performance compared with the former methods on disease classification and grounding.

Text-to-image diffusion models have an unprecedented ability to generate diverse and high-quality images. However, they often struggle to faithfully capture the intended semantics of complex input prompts that include multiple subjects. Recently, numerous layout-to-image extensions have been introduced to improve user control, aiming to localize subjects represented by specific tokens. Yet, these methods often produce semantically inaccurate images, especially when dealing with multiple semantically or visually similar subjects. In this work, we study and analyze the causes of these limitations. Our exploration reveals that the primary issue stems from inadvertent semantic leakage between subjects in the denoising process. This leakage is attributed to the diffusion model's attention layers, which tend to blend the visual features of different subjects. To address these issues, we introduce Bounded Attention, a training-free method for bounding the information flow in the sampling process. Bounded Attention prevents detrimental leakage among subjects and enables guiding the generation to promote each subject's individuality, even with complex multi-subject conditioning. Through extensive experimentation, we demonstrate that our method empowers the generation of multiple subjects that better align with given prompts and layouts.

The growing computational demands posed by increasingly number of neural network's parameters necessitate low-memory-consumption training approaches. Previous memory reduction techniques, such as Low-Rank Adaptation (LoRA) and ReLoRA, suffer from the limitation of low rank and saddle point issues, particularly during intensive tasks like pre-training. In this paper, we propose Sparse Spectral Training (SST), an advanced training methodology that updates all singular values and selectively updates singular vectors of network weights, thereby optimizing resource usage while closely approximating full-rank training. SST refines the training process by employing a targeted updating strategy for singular vectors, which is determined by a multinomial sampling method weighted by the significance of the singular values, ensuring both high performance and memory reduction. Through comprehensive testing on both Euclidean and hyperbolic neural networks across various tasks, including natural language generation, machine translation, node classification and link prediction, SST demonstrates its capability to outperform existing memory reduction training methods and is comparable with full-rank training in some cases. On OPT-125M, with rank equating to 8.3% of embedding dimension, SST reduces the perplexity gap to full-rank training by 67.6%, demonstrating a significant reduction of the performance loss with prevalent low-rank methods. This approach offers a strong alternative to traditional training techniques, paving the way for more efficient and scalable neural network training solutions.

The premise of identifiable and causal representation learning is to improve the current representation learning paradigm in terms of generalizability or robustness. Despite recent progress in questions of identifiability, more theoretical results demonstrating concrete advantages of these methods for downstream tasks are needed. In this paper, we consider the task of intervention extrapolation: predicting how interventions affect an outcome, even when those interventions are not observed at training time, and show that identifiable representations can provide an effective solution to this task even if the interventions affect the outcome non-linearly. Our setup includes an outcome Y, observed features X, which are generated as a non-linear transformation of latent features Z, and exogenous action variables A, which influence Z. The objective of intervention extrapolation is to predict how interventions on A that lie outside the training support of A affect Y. Here, extrapolation becomes possible if the effect of A on Z is linear and the residual when regressing Z on A has full support. As Z is latent, we combine the task of intervention extrapolation with identifiable representation learning, which we call Rep4Ex: we aim to map the observed features X into a subspace that allows for non-linear extrapolation in A. We show that the hidden representation is identifiable up to an affine transformation in Z-space, which is sufficient for intervention extrapolation. The identifiability is characterized by a novel constraint describing the linearity assumption of A on Z. Based on this insight, we propose a method that enforces the linear invariance constraint and can be combined with any type of autoencoder. We validate our theoretical findings through synthetic experiments and show that our approach succeeds in predicting the effects of unseen interventions.

Sleep is a complex physiological process evaluated through various modalities recording electrical brain, cardiac, and respiratory activities. We curate a large polysomnography dataset from over 14,000 participants comprising over 100,000 hours of multi-modal sleep recordings. Leveraging this extensive dataset, we developed SleepFM, the first multi-modal foundation model for sleep analysis. We show that a novel leave-one-out approach for contrastive learning significantly improves downstream task performance compared to representations from standard pairwise contrastive learning. A logistic regression model trained on SleepFM's learned embeddings outperforms an end-to-end trained convolutional neural network (CNN) on sleep stage classification (macro AUROC 0.88 vs 0.72 and macro AUPRC 0.72 vs 0.48) and sleep disordered breathing detection (AUROC 0.85 vs 0.69 and AUPRC 0.77 vs 0.61). Notably, the learned embeddings achieve 48% top-1 average accuracy in retrieving the corresponding recording clips of other modalities from 90,000 candidates. This work demonstrates the value of holistic multi-modal sleep modeling to fully capture the richness of sleep recordings. SleepFM is open source and available at https://github.com/rthapa84/sleepfm-codebase.

Pretrained models have become a commodity and offer strong results on a broad range of tasks. In this work, we focus on classification and seek to learn a unique encoder able to take from several complementary pretrained models. We aim at even stronger generalization across a variety of classification tasks. We propose to learn such an encoder via multi-teacher distillation. We first thoroughly analyse standard distillation when driven by multiple strong teachers with complementary strengths. Guided by this analysis, we gradually propose improvements to the basic distillation setup. Among those, we enrich the architecture of the encoder with a ladder of expendable projectors, which increases the impact of intermediate features during distillation, and we introduce teacher dropping, a regularization mechanism that better balances the teachers' influence. Our final distillation strategy leads to student models of the same capacity as any of the teachers, while retaining or improving upon the performance of the best teacher for each task. Project page and code: https://europe.naverlabs.com/unic

Attention-based graph neural networks (GNNs), such as graph attention networks (GATs), have become popular neural architectures for processing graph-structured data and learning node embeddings. Despite their empirical success, these models rely on labeled data and the theoretical properties of these models have yet to be fully understood. In this work, we propose a novel attention-based node embedding framework for graphs. Our framework builds upon a hierarchical kernel for multisets of subgraphs around nodes (e.g. neighborhoods) and each kernel leverages the geometry of a smooth statistical manifold to compare pairs of multisets, by "projecting" the multisets onto the manifold. By explicitly computing node embeddings with a manifold of Gaussian mixtures, our method leads to a new attention mechanism for neighborhood aggregation. We provide theoretical insights into generalizability and expressivity of our embeddings, contributing to a deeper understanding of attention-based GNNs. We propose both efficient unsupervised and supervised methods for learning the embeddings. Through experiments on several node classification benchmarks, we demonstrate that our proposed method outperforms existing attention-based graph models like GATs. Our code is available at https://github.com/BorgwardtLab/fisher_information_embedding.

Recently, text-to-image diffusion models have demonstrated impressive ability to generate high-quality images conditioned on the textual input. However, these models struggle to accurately adhere to textual instructions regarding spatial layout information. While previous research has primarily focused on aligning cross-attention maps with layout conditions, they overlook the impact of the initialization noise on the layout guidance. To achieve better layout control, we propose leveraging a spatial-aware initialization noise during the denoising process. Specifically, we find that the inverted reference image with finite inversion steps contains valuable spatial awareness regarding the object's position, resulting in similar layouts in the generated images. Based on this observation, we develop an open-vocabulary framework to customize a spatial-aware initialization noise for each layout condition. Without modifying other modules except the initialization noise, our approach can be seamlessly integrated as a plug-and-play module within other training-free layout guidance frameworks. We evaluate our approach quantitatively and qualitatively on the available Stable Diffusion model and COCO dataset. Equipped with the spatial-aware latent initialization, our method significantly improves the effectiveness of layout guidance while preserving high-quality content.

Two competing paradigms exist for self-supervised learning of data representations. Joint Embedding Predictive Architecture (JEPA) is a class of architectures in which semantically similar inputs are encoded into representations that are predictive of each other. A recent successful approach that falls under the JEPA framework is self-distillation, where an online encoder is trained to predict the output of the target encoder, sometimes using a lightweight predictor network. This is contrasted with the Masked AutoEncoder (MAE) paradigm, where an encoder and decoder are trained to reconstruct missing parts of the input in the data space rather, than its latent representation. A common motivation for using the JEPA approach over MAE is that the JEPA objective prioritizes abstract features over fine-grained pixel information (which can be unpredictable and uninformative). In this work, we seek to understand the mechanism behind this empirical observation by analyzing the training dynamics of deep linear models. We uncover a surprising mechanism: in a simplified linear setting where both approaches learn similar representations, JEPAs are biased to learn high-influence features, i.e., features characterized by having high regression coefficients. Our results point to a distinct implicit bias of predicting in latent space that may shed light on its success in practice.

Joint embedding (JE) architectures have emerged as a promising avenue for acquiring transferable data representations. A key obstacle to using JE methods, however, is the inherent challenge of evaluating learned representations without access to a downstream task, and an annotated dataset. Without efficient and reliable evaluation, it is difficult to iterate on architectural and training choices for JE methods. In this paper, we introduce LiDAR (Linear Discriminant Analysis Rank), a metric designed to measure the quality of representations within JE architectures. Our metric addresses several shortcomings of recent approaches based on feature covariance rank by discriminating between informative and uninformative features. In essence, LiDAR quantifies the rank of the Linear Discriminant Analysis (LDA) matrix associated with the surrogate SSL task -- a measure that intuitively captures the information content as it pertains to solving the SSL task. We empirically demonstrate that LiDAR significantly surpasses naive rank based approaches in its predictive power of optimal hyperparameters. Our proposed criterion presents a more robust and intuitive means of assessing the quality of representations within JE architectures, which we hope facilitates broader adoption of these powerful techniques in various domains.

We present SegFormer, a simple, efficient yet powerful semantic segmentation framework which unifies Transformers with lightweight multilayer perception (MLP) decoders. SegFormer has two appealing features: 1) SegFormer comprises a novel hierarchically structured Transformer encoder which outputs multiscale features. It does not need positional encoding, thereby avoiding the interpolation of positional codes which leads to decreased performance when the testing resolution differs from training. 2) SegFormer avoids complex decoders. The proposed MLP decoder aggregates information from different layers, and thus combining both local attention and global attention to render powerful representations. We show that this simple and lightweight design is the key to efficient segmentation on Transformers. We scale our approach up to obtain a series of models from SegFormer-B0 to SegFormer-B5, reaching significantly better performance and efficiency than previous counterparts. For example, SegFormer-B4 achieves 50.3% mIoU on ADE20K with 64M parameters, being 5x smaller and 2.2% better than the previous best method. Our best model, SegFormer-B5, achieves 84.0% mIoU on Cityscapes validation set and shows excellent zero-shot robustness on Cityscapes-C. Code will be released at: github.com/NVlabs/SegFormer.

Pedestrian intention prediction is crucial for autonomous driving. In particular, knowing if pedestrians are going to cross in front of the ego-vehicle is core to performing safe and comfortable maneuvers. Creating accurate and fast models that predict such intentions from sequential images is challenging. A factor contributing to this is the lack of datasets with diverse crossing and non-crossing (C/NC) scenarios. We address this scarceness by introducing a framework, named ARCANE, which allows programmatically generating synthetic datasets consisting of C/NC video clip samples. As an example, we use ARCANE to generate a large and diverse dataset named PedSynth. We will show how PedSynth complements widely used real-world datasets such as JAAD and PIE, so enabling more accurate models for C/NC prediction. Considering the onboard deployment of C/NC prediction models, we also propose a deep model named PedGNN, which is fast and has a very low memory footprint. PedGNN is based on a GNN-GRU architecture that takes a sequence of pedestrian skeletons as input to predict crossing intentions.

With the development of Deep Neural Networks (DNNs), many efforts have been made to handle medical image segmentation. Traditional methods such as nnUNet train specific segmentation models on the individual datasets. Plenty of recent methods have been proposed to adapt the foundational Segment Anything Model (SAM) to medical image segmentation. However, they still focus on discrete representations to generate pixel-wise predictions, which are spatially inflexible and scale poorly to higher resolution. In contrast, implicit methods learn continuous representations for segmentation, which is crucial for medical image segmentation. In this paper, we propose I-MedSAM, which leverages the benefits of both continuous representations and SAM, to obtain better cross-domain ability and accurate boundary delineation. Since medical image segmentation needs to predict detailed segmentation boundaries, we designed a novel adapter to enhance the SAM features with high-frequency information during Parameter-Efficient Fine-Tuning (PEFT). To convert the SAM features and coordinates into continuous segmentation output, we utilize Implicit Neural Representation (INR) to learn an implicit segmentation decoder. We also propose an uncertainty-guided sampling strategy for efficient learning of INR. Extensive evaluations on 2D medical image segmentation tasks have shown that our proposed method with only 1.6M trainable parameters outperforms existing methods including discrete and implicit methods. The code will be available at: https://github.com/ucwxb/I-MedSAM.

Few-shot learning is a challenging area of research that aims to learn new concepts with only a few labeled samples of data. Recent works based on metric-learning approaches leverage the meta-learning approach, which is encompassed by episodic tasks that make use a support (training) and query set (test) with the objective of learning a similarity comparison metric between those sets. Due to the lack of data, the learning process of the embedding network becomes an important part of the few-shot task. Previous works have addressed this problem using metric learning approaches, but the properties of the underlying latent space and the separability of the difference classes on it was not entirely enforced. In this work, we propose two different loss functions which consider the importance of the embedding vectors by looking at the intra-class and inter-class distance between the few data. The first loss function is the Proto-Triplet Loss, which is based on the original triplet loss with the modifications needed to better work on few-shot scenarios. The second loss function, which we dub ICNN loss is based on an inter and intra class nearest neighbors score, which help us to assess the quality of embeddings obtained from the trained network. Our results, obtained from a extensive experimental setup show a significant improvement in accuracy in the miniImagenNet benchmark compared to other metric-based few-shot learning methods by a margin of 2%, demonstrating the capability of these loss functions to allow the network to generalize better to previously unseen classes. In our experiments, we demonstrate competitive generalization capabilities to other domains, such as the Caltech CUB, Dogs and Cars datasets compared with the state of the art.

The development of large language models (LLMs) has significantly advanced the emergence of large multimodal models (LMMs). While LMMs have achieved tremendous success by promoting the synergy between multimodal comprehension and creation, they often face challenges when confronted with out-of-distribution data. This is primarily due to their reliance on image encoders trained to encode images into task-relevant features, which may lead them to disregard irrelevant details. Delving into the modeling capabilities of diffusion models for images naturally prompts the question: Can diffusion models serve as the eyes of large language models for image perception? In this paper, we propose DEEM, a simple and effective approach that utilizes the generative feedback of diffusion models to align the semantic distributions of the image encoder. This addresses the drawbacks of previous methods that solely relied on image encoders like ViT, thereby enhancing the model's resilience against out-of-distribution samples and reducing visual hallucinations. Importantly, this is achieved without requiring additional training modules and with fewer training parameters. We extensively evaluated DEEM on both our newly constructed RobustVQA benchmark and another well-known benchmark, POPE, for object hallucination. Compared to the state-of-the-art interleaved content generation models, DEEM exhibits enhanced robustness and a superior capacity to alleviate model hallucinations while utilizing fewer trainable parameters, less pre-training data (10%), and a smaller base model size.

We propose DiTFlow, a method for transferring the motion of a reference video to a newly synthesized one, designed specifically for Diffusion Transformers (DiT). We first process the reference video with a pre-trained DiT to analyze cross-frame attention maps and extract a patch-wise motion signal called the Attention Motion Flow (AMF). We guide the latent denoising process in an optimization-based, training-free, manner by optimizing latents with our AMF loss to generate videos reproducing the motion of the reference one. We also apply our optimization strategy to transformer positional embeddings, granting us a boost in zero-shot motion transfer capabilities. We evaluate DiTFlow against recently published methods, outperforming all across multiple metrics and human evaluation.

Deep neural networks are susceptible to generating overconfident yet erroneous predictions when presented with data beyond known concepts. This challenge underscores the importance of detecting out-of-distribution (OOD) samples in the open world. In this work, we propose a novel feature-space OOD detection score based on class-specific and class-agnostic information. Specifically, the approach utilizes Whitened Linear Discriminant Analysis to project features into two subspaces - the discriminative and residual subspaces - for which the in-distribution (ID) classes are maximally separated and closely clustered, respectively. The OOD score is then determined by combining the deviation from the input data to the ID pattern in both subspaces. The efficacy of our method, named WDiscOOD, is verified on the large-scale ImageNet-1k benchmark, with six OOD datasets that cover a variety of distribution shifts. WDiscOOD demonstrates superior performance on deep classifiers with diverse backbone architectures, including CNN and vision transformer. Furthermore, we also show that WDiscOOD more effectively detects novel concepts in representation spaces trained with contrastive objectives, including supervised contrastive loss and multi-modality contrastive loss.

We introduce MURA, a large dataset of musculoskeletal radiographs containing 40,561 images from 14,863 studies, where each study is manually labeled by radiologists as either normal or abnormal. To evaluate models robustly and to get an estimate of radiologist performance, we collect additional labels from six board-certified Stanford radiologists on the test set, consisting of 207 musculoskeletal studies. On this test set, the majority vote of a group of three radiologists serves as gold standard. We train a 169-layer DenseNet baseline model to detect and localize abnormalities. Our model achieves an AUROC of 0.929, with an operating point of 0.815 sensitivity and 0.887 specificity. We compare our model and radiologists on the Cohen's kappa statistic, which expresses the agreement of our model and of each radiologist with the gold standard. Model performance is comparable to the best radiologist performance in detecting abnormalities on finger and wrist studies. However, model performance is lower than best radiologist performance in detecting abnormalities on elbow, forearm, hand, humerus, and shoulder studies. We believe that the task is a good challenge for future research. To encourage advances, we have made our dataset freely available at https://stanfordmlgroup.github.io/competitions/mura .

Autism spectrum disorder (ASD) is a prevalent psychiatric condition characterized by atypical cognitive, emotional, and social patterns. Timely and accurate diagnosis is crucial for effective interventions and improved outcomes in individuals with ASD. In this study, we propose a novel Multi-Atlas Enhanced Transformer framework, METAFormer, ASD classification. Our framework utilizes resting-state functional magnetic resonance imaging data from the ABIDE I dataset, comprising 406 ASD and 476 typical control (TC) subjects. METAFormer employs a multi-atlas approach, where flattened connectivity matrices from the AAL, CC200, and DOS160 atlases serve as input to the transformer encoder. Notably, we demonstrate that self-supervised pretraining, involving the reconstruction of masked values from the input, significantly enhances classification performance without the need for additional or separate training data. Through stratified cross-validation, we evaluate the proposed framework and show that it surpasses state-of-the-art performance on the ABIDE I dataset, with an average accuracy of 83.7% and an AUC-score of 0.832. The code for our framework is available at https://github.com/Lugges991/METAFormer

The task of out-of-distribution (OOD) detection is notoriously ill-defined. Earlier works focused on new-class detection, aiming to identify label-altering data distribution shifts, also known as "semantic shift." However, recent works argue for a focus on failure detection, expanding the OOD evaluation framework to account for label-preserving data distribution shifts, also known as "covariate shift." Intriguingly, under this new framework, complex OOD detectors that were previously considered state-of-the-art now perform similarly to, or even worse than the simple maximum softmax probability baseline. This raises the question: what are the latest OOD detectors actually detecting? Deciphering the behavior of OOD detection algorithms requires evaluation datasets that decouples semantic shift and covariate shift. To aid our investigations, we present ImageNet-OOD, a clean semantic shift dataset that minimizes the interference of covariate shift. Through comprehensive experiments, we show that OOD detectors are more sensitive to covariate shift than to semantic shift, and the benefits of recent OOD detection algorithms on semantic shift detection is minimal. Our dataset and analyses provide important insights for guiding the design of future OOD detectors.

We propose two novel purpose-built deep learning (DL) models for synthesis of the arterial blood pressure (ABP) waveform in a cuff-less manner, using a single-site photoplethysmography (PPG) signal. We utilize the public UCI dataset on cuff-less blood pressure (CLBP) estimation to train and evaluate our DL models. Firstly, we implement a transformer model that incorporates positional encoding, multi-head attention, layer normalization, and dropout techniques, and synthesizes the ABP waveform with a mean absolute error (MAE) of 14. Secondly, we implement a frequency-domain (FD) learning approach where we first obtain the discrete cosine transform (DCT) coefficients of the PPG and ABP signals corresponding to two cardiac cycles, and then learn a linear/non-linear (L/NL) regression between them. We learn that the FD L/NL regression model outperforms the transformer model by achieving an MAE of 11.87 and 8.01, for diastolic blood pressure (DBP) and systolic blood pressure (SBP), respectively. Our FD L/NL regression model also fulfills the AAMI criterion of utilizing data from more than 85 subjects, and achieves grade B by the BHS criterion.

With the growing popularity of text-to-image generative models, there has been increasing focus on understanding their risks and biases. Recent work has found that state-of-the-art models struggle to depict everyday objects with the true diversity of the real world and have notable gaps between geographic regions. In this work, we aim to increase the diversity of generated images of common objects such that per-region variations are representative of the real world. We introduce an inference time intervention, contextualized Vendi Score Guidance (c-VSG), that guides the backwards steps of latent diffusion models to increase the diversity of a sample as compared to a "memory bank" of previously generated images while constraining the amount of variation within that of an exemplar set of real-world contextualizing images. We evaluate c-VSG with two geographically representative datasets and find that it substantially increases the diversity of generated images, both for the worst performing regions and on average, while simultaneously maintaining or improving image quality and consistency. Additionally, qualitative analyses reveal that diversity of generated images is significantly improved, including along the lines of reductive region portrayals present in the original model. We hope that this work is a step towards text-to-image generative models that reflect the true geographic diversity of the world.

Recent advances in Conditional Diffusion Models have led to substantial capabilities in various domains. However, understanding the impact of variations in the initial seed vector remains an underexplored area of concern. Particularly, latent-based diffusion models display inconsistencies in image generation under standard conditions when initialized with suboptimal initial seed vectors. To understand the impact of the initial seed vector on generated samples, we propose a reliability evaluation framework that evaluates the generated samples of a diffusion model when the initial seed vector is subjected to various synthetic shifts. Our results indicate that slight manipulations to the initial seed vector of the state-of-the-art Stable Diffusion (Rombach et al., 2022) can lead to significant disturbances in the generated samples, consequently creating images without the effect of conditioning variables. In contrast, GLIDE (Nichol et al., 2022) stands out in generating reliable samples even when the initial seed vector is transformed. Thus, our study sheds light on the importance of the selection and the impact of the initial seed vector in the latent-based diffusion model.

The rapid advancement of text-to-image (T2I) diffusion models has enabled them to generate unprecedented results from given texts. However, as text inputs become longer, existing encoding methods like CLIP face limitations, and aligning the generated images with long texts becomes challenging. To tackle these issues, we propose LongAlign, which includes a segment-level encoding method for processing long texts and a decomposed preference optimization method for effective alignment training. For segment-level encoding, long texts are divided into multiple segments and processed separately. This method overcomes the maximum input length limits of pretrained encoding models. For preference optimization, we provide decomposed CLIP-based preference models to fine-tune diffusion models. Specifically, to utilize CLIP-based preference models for T2I alignment, we delve into their scoring mechanisms and find that the preference scores can be decomposed into two components: a text-relevant part that measures T2I alignment and a text-irrelevant part that assesses other visual aspects of human preference. Additionally, we find that the text-irrelevant part contributes to a common overfitting problem during fine-tuning. To address this, we propose a reweighting strategy that assigns different weights to these two components, thereby reducing overfitting and enhancing alignment. After fine-tuning 512 times 512 Stable Diffusion (SD) v1.5 for about 20 hours using our method, the fine-tuned SD outperforms stronger foundation models in T2I alignment, such as PixArt-alpha and Kandinsky v2.2. The code is available at https://github.com/luping-liu/LongAlign.

We present a framework for the unsupervised learning of neurosymbolic encoders, which are encoders obtained by composing neural networks with symbolic programs from a domain-specific language. Our framework naturally incorporates symbolic expert knowledge into the learning process, which leads to more interpretable and factorized latent representations compared to fully neural encoders. We integrate modern program synthesis techniques with the variational autoencoding (VAE) framework, in order to learn a neurosymbolic encoder in conjunction with a standard decoder. The programmatic descriptions from our encoders can benefit many analysis workflows, such as in behavior modeling where interpreting agent actions and movements is important. We evaluate our method on learning latent representations for real-world trajectory data from animal biology and sports analytics. We show that our approach offers significantly better separation of meaningful categories than standard VAEs and leads to practical gains on downstream analysis tasks, such as for behavior classification.

Deep learning approaches to natural language processing have made great strides in recent years. While these models produce symbols that convey vast amounts of diverse knowledge, it is unclear how such symbols are grounded in data from the world. In this paper, we explore the development of a private language for visual data representation by training emergent language (EL) encoders/decoders in both i) a traditional referential game environment and ii) a contrastive learning environment utilizing a within-class matching training paradigm. An additional classification layer utilizing neural machine translation and random forest classification was used to transform symbolic representations (sequences of integer symbols) to class labels. These methods were applied in two experiments focusing on object recognition and action recognition. For object recognition, a set of sketches produced by human participants from real imagery was used (Sketchy dataset) and for action recognition, 2D trajectories were generated from 3D motion capture systems (MOVI dataset). In order to interpret the symbols produced for data in each experiment, gradient-weighted class activation mapping (Grad-CAM) methods were used to identify pixel regions indicating semantic features which contribute evidence towards symbols in learned languages. Additionally, a t-distributed stochastic neighbor embedding (t-SNE) method was used to investigate embeddings learned by CNN feature extractors.

The posterior collapse phenomenon in variational autoencoder (VAE), where the variational posterior distribution closely matches the prior distribution, can hinder the quality of the learned latent variables. As a consequence of posterior collapse, the latent variables extracted by the encoder in VAE preserve less information from the input data and thus fail to produce meaningful representations as input to the reconstruction process in the decoder. While this phenomenon has been an actively addressed topic related to VAE performance, the theory for posterior collapse remains underdeveloped, especially beyond the standard VAE. In this work, we advance the theoretical understanding of posterior collapse to two important and prevalent yet less studied classes of VAE: conditional VAE and hierarchical VAE. Specifically, via a non-trivial theoretical analysis of linear conditional VAE and hierarchical VAE with two levels of latent, we prove that the cause of posterior collapses in these models includes the correlation between the input and output of the conditional VAE and the effect of learnable encoder variance in the hierarchical VAE. We empirically validate our theoretical findings for linear conditional and hierarchical VAE and demonstrate that these results are also predictive for non-linear cases with extensive experiments.

Medical images are acquired at high resolutions with large fields of view in order to capture fine-grained features necessary for clinical decision-making. Consequently, training deep learning models on medical images can incur large computational costs. In this work, we address the challenge of downsizing medical images in order to improve downstream computational efficiency while preserving clinically-relevant features. We introduce MedVAE, a family of six large-scale 2D and 3D autoencoders capable of encoding medical images as downsized latent representations and decoding latent representations back to high-resolution images. We train MedVAE autoencoders using a novel two-stage training approach with 1,052,730 medical images. Across diverse tasks obtained from 20 medical image datasets, we demonstrate that (1) utilizing MedVAE latent representations in place of high-resolution images when training downstream models can lead to efficiency benefits (up to 70x improvement in throughput) while simultaneously preserving clinically-relevant features and (2) MedVAE can decode latent representations back to high-resolution images with high fidelity. Our work demonstrates that large-scale, generalizable autoencoders can help address critical efficiency challenges in the medical domain. Our code is available at https://github.com/StanfordMIMI/MedVAE.

In large vision-language models (LVLMs), images serve as inputs that carry a wealth of information. As the idiom "A picture is worth a thousand words" implies, representing a single image in current LVLMs can require hundreds or even thousands of tokens. This results in significant computational costs, which grow quadratically as input image resolution increases, thereby severely impacting the efficiency of both training and inference. Previous approaches have attempted to reduce the number of image tokens either before or within the early layers of LVLMs. However, these strategies inevitably result in the loss of crucial image information, ultimately diminishing model performance. To address this challenge, we conduct an empirical study revealing that all visual tokens are necessary for LVLMs in the shallow layers, and token redundancy progressively increases in the deeper layers of the model. To this end, we propose PyramidDrop, a visual redundancy reduction strategy for LVLMs to boost their efficiency in both training and inference with neglectable performance loss. Specifically, we partition the LVLM into several stages and drop part of the image tokens at the end of each stage with a pre-defined ratio, creating pyramid-like visual tokens across model layers. The dropping is based on a lightweight similarity calculation with a negligible time overhead. Extensive experiments demonstrate that PyramidDrop can achieve a 40% training time and 55% inference FLOPs acceleration of LLaVA-NeXT with comparable performance. Besides, the PyramidDrop could also serve as a plug-and-play strategy for inference acceleration without training, with better performance and lower inference cost than counterparts. We hope that the insights and approach introduced by PyramidDrop will inspire future research to further investigate the role of image tokens in LVLMs.

Neural networks embed the geometric structure of a data manifold lying in a high-dimensional space into latent representations. Ideally, the distribution of the data points in the latent space should depend only on the task, the data, the loss, and other architecture-specific constraints. However, factors such as the random weights initialization, training hyperparameters, or other sources of randomness in the training phase may induce incoherent latent spaces that hinder any form of reuse. Nevertheless, we empirically observe that, under the same data and modeling choices, the angles between the encodings within distinct latent spaces do not change. In this work, we propose the latent similarity between each sample and a fixed set of anchors as an alternative data representation, demonstrating that it can enforce the desired invariances without any additional training. We show how neural architectures can leverage these relative representations to guarantee, in practice, invariance to latent isometries and rescalings, effectively enabling latent space communication: from zero-shot model stitching to latent space comparison between diverse settings. We extensively validate the generalization capability of our approach on different datasets, spanning various modalities (images, text, graphs), tasks (e.g., classification, reconstruction) and architectures (e.g., CNNs, GCNs, transformers).

Post-hoc explanation methods have often been criticised for abstracting away the decision-making process of deep neural networks. In this work, we would like to provide natural language descriptions for what different layers of a vision backbone have learned. Our DeViL method decodes vision features into language, not only highlighting the attribution locations but also generating textual descriptions of visual features at different layers of the network. We train a transformer network to translate individual image features of any vision layer into a prompt that a separate off-the-shelf language model decodes into natural language. By employing dropout both per-layer and per-spatial-location, our model can generalize training on image-text pairs to generate localized explanations. As it uses a pre-trained language model, our approach is fast to train, can be applied to any vision backbone, and produces textual descriptions at different layers of the vision network. Moreover, DeViL can create open-vocabulary attribution maps corresponding to words or phrases even outside the training scope of the vision model. We demonstrate that DeViL generates textual descriptions relevant to the image content on CC3M surpassing previous lightweight captioning models and attribution maps uncovering the learned concepts of the vision backbone. Finally, we show DeViL also outperforms the current state-of-the-art on the neuron-wise descriptions of the MILANNOTATIONS dataset. Code available at https://github.com/ExplainableML/DeViL

Training convolutional neural networks (CNNs) for segmentation of pulmonary airway, artery, and vein is challenging due to sparse supervisory signals caused by the severe class imbalance between tubular targets and background. We present a CNNs-based method for accurate airway and artery-vein segmentation in non-contrast computed tomography. It enjoys superior sensitivity to tenuous peripheral bronchioles, arterioles, and venules. The method first uses a feature recalibration module to make the best use of features learned from the neural networks. Spatial information of features is properly integrated to retain relative priority of activated regions, which benefits the subsequent channel-wise recalibration. Then, attention distillation module is introduced to reinforce representation learning of tubular objects. Fine-grained details in high-resolution attention maps are passing down from one layer to its previous layer recursively to enrich context. Anatomy prior of lung context map and distance transform map is designed and incorporated for better artery-vein differentiation capacity. Extensive experiments demonstrated considerable performance gains brought by these components. Compared with state-of-the-art methods, our method extracted much more branches while maintaining competitive overall segmentation performance. Codes and models are available at http://www.pami.sjtu.edu.cn/News/56

The vision tokens in multimodal large language models usually exhibit significant spatial and temporal redundancy and take up most of the input tokens, which harms their inference efficiency. To solve this problem, some recent works were introduced to drop the unimportant tokens during inference where the importance of each token is decided only by the information in either the vision encoding stage or the prefilling stage. In this paper, we propose Multi-stage Token Dropping (MustDrop) to measure the importance of each token from the whole lifecycle, including the vision encoding stage, prefilling stage, and decoding stage. Concretely, in the visual encoding stage, MustDrop merges spatially adjacent tokens with high similarity, and establishes a key token set to retain the most vision-critical tokens, preventing them from being discarded in later stages. In the prefilling stage, MustDrop further compresses vision tokens by the guidance of text semantics, with a dual-attention filtering strategy. In the decoding stage, an output-aware cache policy is proposed to further reduce the size of the KV cache. By leveraging tailored strategies in the multi-stage process, MustDrop can more precisely recognize the important and redundant tokens, thus achieving an optimal balance between performance and efficiency. For instance, MustDrop reduces about 88.5\% FLOPs on LLaVA with a compression ratio of 92.2\% while maintaining comparable accuracy. Our codes are available at https://github.com/liuting20/MustDrop.

Denoising Diffusion Probabilistic Models have shown an impressive generation quality, although their long sampling chain leads to high computational costs. In this paper, we observe that a long sampling chain also leads to an error accumulation phenomenon, which is similar to the exposure bias problem in autoregressive text generation. Specifically, we note that there is a discrepancy between training and testing, since the former is conditioned on the ground truth samples, while the latter is conditioned on the previously generated results. To alleviate this problem, we propose a very simple but effective training regularization, consisting in perturbing the ground truth samples to simulate the inference time prediction errors. We empirically show that, without affecting the recall and precision, the proposed input perturbation leads to a significant improvement in the sample quality while reducing both the training and the inference times. For instance, on CelebA 64times64, we achieve a new state-of-the-art FID score of 1.27, while saving 37.5% of the training time. The code is publicly available at https://github.com/forever208/DDPM-IP